A ribose-functionalized NAD+ with unexpected high activity and selectivity for protein poly-ADP-ribosylation
The study of NAD+ dependent ADP-ribosylation can be challenging. Here the authors report on the development of NAD+ analogues, using chemo-enzymatic methods, which can be used as probes to label the substrate proteins of poly-ADP-ribose polymerase.
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| Auteurs principaux: | , , , , , , , , , |
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| Format: | article |
| Langue: | EN |
| Publié: |
Nature Portfolio
2019
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| Sujets: | |
| Accès en ligne: | https://doaj.org/article/99a2c69f536344e0816740d2ed77a8f6 |
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| Résumé: | The study of NAD+ dependent ADP-ribosylation can be challenging. Here the authors report on the development of NAD+ analogues, using chemo-enzymatic methods, which can be used as probes to label the substrate proteins of poly-ADP-ribose polymerase. |
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