A ribose-functionalized NAD+ with unexpected high activity and selectivity for protein poly-ADP-ribosylation

The study of NAD+ dependent ADP-ribosylation can be challenging. Here the authors report on the development of NAD+ analogues, using chemo-enzymatic methods, which can be used as probes to label the substrate proteins of poly-ADP-ribose polymerase.

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Autores principales:	Xiao-Nan Zhang, Qinqin Cheng, Jingwen Chen, Albert T. Lam, Yanran Lu, Zhefu Dai, Hua Pei, Nikolai M. Evdokimov, Stan G. Louie, Yong Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/99a2c69f536344e0816740d2ed77a8f6
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spelling	oai:doaj.org-article:99a2c69f536344e0816740d2ed77a8f62021-12-02T16:58:19ZA ribose-functionalized NAD+ with unexpected high activity and selectivity for protein poly-ADP-ribosylation10.1038/s41467-019-12215-42041-1723https://doaj.org/article/99a2c69f536344e0816740d2ed77a8f62019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12215-4https://doaj.org/toc/2041-1723The study of NAD+ dependent ADP-ribosylation can be challenging. Here the authors report on the development of NAD+ analogues, using chemo-enzymatic methods, which can be used as probes to label the substrate proteins of poly-ADP-ribose polymerase.Xiao-Nan ZhangQinqin ChengJingwen ChenAlbert T. LamYanran LuZhefu DaiHua PeiNikolai M. EvdokimovStan G. LouieYong ZhangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiao-Nan Zhang Qinqin Cheng Jingwen Chen Albert T. Lam Yanran Lu Zhefu Dai Hua Pei Nikolai M. Evdokimov Stan G. Louie Yong Zhang A ribose-functionalized NAD+ with unexpected high activity and selectivity for protein poly-ADP-ribosylation
description	The study of NAD+ dependent ADP-ribosylation can be challenging. Here the authors report on the development of NAD+ analogues, using chemo-enzymatic methods, which can be used as probes to label the substrate proteins of poly-ADP-ribose polymerase.
format	article
author	Xiao-Nan Zhang Qinqin Cheng Jingwen Chen Albert T. Lam Yanran Lu Zhefu Dai Hua Pei Nikolai M. Evdokimov Stan G. Louie Yong Zhang
author_facet	Xiao-Nan Zhang Qinqin Cheng Jingwen Chen Albert T. Lam Yanran Lu Zhefu Dai Hua Pei Nikolai M. Evdokimov Stan G. Louie Yong Zhang
author_sort	Xiao-Nan Zhang
title	A ribose-functionalized NAD+ with unexpected high activity and selectivity for protein poly-ADP-ribosylation
title_short	A ribose-functionalized NAD+ with unexpected high activity and selectivity for protein poly-ADP-ribosylation
title_full	A ribose-functionalized NAD+ with unexpected high activity and selectivity for protein poly-ADP-ribosylation
title_fullStr	A ribose-functionalized NAD+ with unexpected high activity and selectivity for protein poly-ADP-ribosylation
title_full_unstemmed	A ribose-functionalized NAD+ with unexpected high activity and selectivity for protein poly-ADP-ribosylation
title_sort	ribose-functionalized nad+ with unexpected high activity and selectivity for protein poly-adp-ribosylation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/99a2c69f536344e0816740d2ed77a8f6
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A ribose-functionalized NAD+ with unexpected high activity and selectivity for protein poly-ADP-ribosylation

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