Nr4a2 Transcription Factor in Hippocampal Synaptic Plasticity, Memory and Cognitive Dysfunction: A Perspective Review

Long-lasting changes of synaptic efficacy are largely mediated by activity-induced gene transcription and are essential for neuronal plasticity and memory. In this scenario, transcription factors have emerged as pivotal players underlying synaptic plasticity and the modification of neural networks r...

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Autores principales:	Judit Català-Solsona, Alfredo J. Miñano-Molina, José Rodríguez-Álvarez
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Nr4a2 transcription factor hippocampus synaptic plasticity brain learning Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/99a7cbcf432644129474a539475b73ca
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spelling	oai:doaj.org-article:99a7cbcf432644129474a539475b73ca2021-11-22T05:19:06ZNr4a2 Transcription Factor in Hippocampal Synaptic Plasticity, Memory and Cognitive Dysfunction: A Perspective Review1662-509910.3389/fnmol.2021.786226https://doaj.org/article/99a7cbcf432644129474a539475b73ca2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnmol.2021.786226/fullhttps://doaj.org/toc/1662-5099Long-lasting changes of synaptic efficacy are largely mediated by activity-induced gene transcription and are essential for neuronal plasticity and memory. In this scenario, transcription factors have emerged as pivotal players underlying synaptic plasticity and the modification of neural networks required for memory formation and consolidation. Hippocampal synaptic dysfunction is widely accepted to underlie the cognitive decline observed in some neurodegenerative disorders including Alzheimer’s disease. Therefore, understanding the molecular pathways regulating gene expression profiles may help to identify new synaptic therapeutic targets. The nuclear receptor 4A subfamily (Nr4a) of transcription factors has been involved in a variety of physiological processes within the hippocampus, ranging from inflammation to neuroprotection. Recent studies have also pointed out a role for the activity-dependent nuclear receptor subfamily 4, group A, member 2 (Nr4a2/Nurr1) in hippocampal synaptic plasticity and cognitive functions, although the underlying molecular mechanisms are still poorly understood. In this review, we highlight the specific effects of Nr4a2 in hippocampal synaptic plasticity and memory formation and we discuss whether the dysregulation of this transcription factor could contribute to hippocampal synaptic dysfunction, altogether suggesting the possibility that Nr4a2 may emerge as a novel synaptic therapeutic target in brain pathologies associated to cognitive dysfunctions.Judit Català-SolsonaJudit Català-SolsonaAlfredo J. Miñano-MolinaAlfredo J. Miñano-MolinaJosé Rodríguez-ÁlvarezJosé Rodríguez-ÁlvarezJosé Rodríguez-ÁlvarezFrontiers Media S.A.articleNr4a2transcription factorhippocampussynaptic plasticitybrainlearningNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Molecular Neuroscience, Vol 14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Nr4a2 transcription factor hippocampus synaptic plasticity brain learning Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Nr4a2 transcription factor hippocampus synaptic plasticity brain learning Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Judit Català-Solsona Judit Català-Solsona Alfredo J. Miñano-Molina Alfredo J. Miñano-Molina José Rodríguez-Álvarez José Rodríguez-Álvarez José Rodríguez-Álvarez Nr4a2 Transcription Factor in Hippocampal Synaptic Plasticity, Memory and Cognitive Dysfunction: A Perspective Review
description	Long-lasting changes of synaptic efficacy are largely mediated by activity-induced gene transcription and are essential for neuronal plasticity and memory. In this scenario, transcription factors have emerged as pivotal players underlying synaptic plasticity and the modification of neural networks required for memory formation and consolidation. Hippocampal synaptic dysfunction is widely accepted to underlie the cognitive decline observed in some neurodegenerative disorders including Alzheimer’s disease. Therefore, understanding the molecular pathways regulating gene expression profiles may help to identify new synaptic therapeutic targets. The nuclear receptor 4A subfamily (Nr4a) of transcription factors has been involved in a variety of physiological processes within the hippocampus, ranging from inflammation to neuroprotection. Recent studies have also pointed out a role for the activity-dependent nuclear receptor subfamily 4, group A, member 2 (Nr4a2/Nurr1) in hippocampal synaptic plasticity and cognitive functions, although the underlying molecular mechanisms are still poorly understood. In this review, we highlight the specific effects of Nr4a2 in hippocampal synaptic plasticity and memory formation and we discuss whether the dysregulation of this transcription factor could contribute to hippocampal synaptic dysfunction, altogether suggesting the possibility that Nr4a2 may emerge as a novel synaptic therapeutic target in brain pathologies associated to cognitive dysfunctions.
format	article
author	Judit Català-Solsona Judit Català-Solsona Alfredo J. Miñano-Molina Alfredo J. Miñano-Molina José Rodríguez-Álvarez José Rodríguez-Álvarez José Rodríguez-Álvarez
author_facet	Judit Català-Solsona Judit Català-Solsona Alfredo J. Miñano-Molina Alfredo J. Miñano-Molina José Rodríguez-Álvarez José Rodríguez-Álvarez José Rodríguez-Álvarez
author_sort	Judit Català-Solsona
title	Nr4a2 Transcription Factor in Hippocampal Synaptic Plasticity, Memory and Cognitive Dysfunction: A Perspective Review
title_short	Nr4a2 Transcription Factor in Hippocampal Synaptic Plasticity, Memory and Cognitive Dysfunction: A Perspective Review
title_full	Nr4a2 Transcription Factor in Hippocampal Synaptic Plasticity, Memory and Cognitive Dysfunction: A Perspective Review
title_fullStr	Nr4a2 Transcription Factor in Hippocampal Synaptic Plasticity, Memory and Cognitive Dysfunction: A Perspective Review
title_full_unstemmed	Nr4a2 Transcription Factor in Hippocampal Synaptic Plasticity, Memory and Cognitive Dysfunction: A Perspective Review
title_sort	nr4a2 transcription factor in hippocampal synaptic plasticity, memory and cognitive dysfunction: a perspective review
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/99a7cbcf432644129474a539475b73ca
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Nr4a2 Transcription Factor in Hippocampal Synaptic Plasticity, Memory and Cognitive Dysfunction: A Perspective Review

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