The cryo-EM structure of the SNX–BAR Mvp1 tetramer

SNX-BAR proteins are a family of PX and BAR domain-containing proteins with pivotal roles in trafficking processes. Here authors present the cryo-EM structure of the full-length fungal SNX-BAR Mvp1, which is an autoinhibited tetramer and provides critical insight into SNX-BAR function and regulation...

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Auteurs principaux: Dapeng Sun, Natalia V. Varlakhanova, Bryan A. Tornabene, Rajesh Ramachandran, Peijun Zhang, Marijn G. J. Ford
Format: article
Langue:EN
Publié: Nature Portfolio 2020
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Accès en ligne:https://doaj.org/article/99a8ac44d31b4943bbb26fff79c4ed3a
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Résumé:SNX-BAR proteins are a family of PX and BAR domain-containing proteins with pivotal roles in trafficking processes. Here authors present the cryo-EM structure of the full-length fungal SNX-BAR Mvp1, which is an autoinhibited tetramer and provides critical insight into SNX-BAR function and regulation.