Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs

MicroRNA cluster 17∼92 plays a critical role in B-cell differentiation. Here the authors show that miR-19 regulates B-cell tolerance via suppressing the expression of PTEN, whereas miR- 17 is essential for early B-cell development independently of Pten, Phlpp2, or Bim.

Guardado en:

Detalles Bibliográficos
Autores principales:	Maoyi Lai, Alicia Gonzalez-Martin, Anthony B. Cooper, Hiroyo Oda, Hyun Yong Jin, Jovan Shepherd, Linling He, Jiang Zhu, David Nemazee, Changchun Xiao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/99a9b5cebeca4de094483492341bfcd1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:99a9b5cebeca4de094483492341bfcd1
record_format	dspace
spelling	oai:doaj.org-article:99a9b5cebeca4de094483492341bfcd12021-12-02T17:32:37ZRegulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs10.1038/ncomms122072041-1723https://doaj.org/article/99a9b5cebeca4de094483492341bfcd12016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12207https://doaj.org/toc/2041-1723MicroRNA cluster 17∼92 plays a critical role in B-cell differentiation. Here the authors show that miR-19 regulates B-cell tolerance via suppressing the expression of PTEN, whereas miR- 17 is essential for early B-cell development independently of Pten, Phlpp2, or Bim.Maoyi LaiAlicia Gonzalez-MartinAnthony B. CooperHiroyo OdaHyun Yong JinJovan ShepherdLinling HeJiang ZhuDavid NemazeeChangchun XiaoNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Maoyi Lai Alicia Gonzalez-Martin Anthony B. Cooper Hiroyo Oda Hyun Yong Jin Jovan Shepherd Linling He Jiang Zhu David Nemazee Changchun Xiao Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs
description	MicroRNA cluster 17∼92 plays a critical role in B-cell differentiation. Here the authors show that miR-19 regulates B-cell tolerance via suppressing the expression of PTEN, whereas miR- 17 is essential for early B-cell development independently of Pten, Phlpp2, or Bim.
format	article
author	Maoyi Lai Alicia Gonzalez-Martin Anthony B. Cooper Hiroyo Oda Hyun Yong Jin Jovan Shepherd Linling He Jiang Zhu David Nemazee Changchun Xiao
author_facet	Maoyi Lai Alicia Gonzalez-Martin Anthony B. Cooper Hiroyo Oda Hyun Yong Jin Jovan Shepherd Linling He Jiang Zhu David Nemazee Changchun Xiao
author_sort	Maoyi Lai
title	Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs
title_short	Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs
title_full	Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs
title_fullStr	Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs
title_full_unstemmed	Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs
title_sort	regulation of b-cell development and tolerance by different members of the mir-17∼92 family micrornas
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/99a9b5cebeca4de094483492341bfcd1
work_keys_str_mv	AT maoyilai regulationofbcelldevelopmentandtolerancebydifferentmembersofthemir1792familymicrornas AT aliciagonzalezmartin regulationofbcelldevelopmentandtolerancebydifferentmembersofthemir1792familymicrornas AT anthonybcooper regulationofbcelldevelopmentandtolerancebydifferentmembersofthemir1792familymicrornas AT hiroyooda regulationofbcelldevelopmentandtolerancebydifferentmembersofthemir1792familymicrornas AT hyunyongjin regulationofbcelldevelopmentandtolerancebydifferentmembersofthemir1792familymicrornas AT jovanshepherd regulationofbcelldevelopmentandtolerancebydifferentmembersofthemir1792familymicrornas AT linlinghe regulationofbcelldevelopmentandtolerancebydifferentmembersofthemir1792familymicrornas AT jiangzhu regulationofbcelldevelopmentandtolerancebydifferentmembersofthemir1792familymicrornas AT davidnemazee regulationofbcelldevelopmentandtolerancebydifferentmembersofthemir1792familymicrornas AT changchunxiao regulationofbcelldevelopmentandtolerancebydifferentmembersofthemir1792familymicrornas
_version_	1718380263598194688

Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs

Ejemplares similares