Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs

Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs

MicroRNA cluster 17∼92 plays a critical role in B-cell differentiation. Here the authors show that miR-19 regulates B-cell tolerance via suppressing the expression of PTEN, whereas miR- 17 is essential for early B-cell development independently of Pten, Phlpp2, or Bim.

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Detalles Bibliográficos
Autores principales: Maoyi Lai, Alicia Gonzalez-Martin, Anthony B. Cooper, Hiroyo Oda, Hyun Yong Jin, Jovan Shepherd, Linling He, Jiang Zhu, David Nemazee, Changchun Xiao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Science
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Acceso en línea:https://doaj.org/article/99a9b5cebeca4de094483492341bfcd1
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