NOVEL PROTECTIVE ROLE OF MONTELUKAST AGAINST ASPIRIN INDUCED GASTRIC ULCERATION IN RABBITS - MONTELUKAST; A REVOLUTIONARY ASPECT

Objective: To assess the gastroprotective effect of montelukast on aspirin induced gastric mucosal ulceration in rabbits. Study Design: Laboratory based quasi experimental study. Place and Duration of Study: National Institute of Health Islamabad and department of Pharmacology and Therapeutics...

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Autores principales:	Syeda Urooj Zaidi, Muhammad Waqar Aslam Khan, Sumetha Yaseen, Mahwish Gul, Zubaida Rashid, Maryam Saqib
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2020
Materias:	aspirin gastroprotection montelukast omeprazole Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/99ac54f6dad5493b9aeacc56d1d41bc4
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spelling	oai:doaj.org-article:99ac54f6dad5493b9aeacc56d1d41bc42021-11-10T03:19:58ZNOVEL PROTECTIVE ROLE OF MONTELUKAST AGAINST ASPIRIN INDUCED GASTRIC ULCERATION IN RABBITS - MONTELUKAST; A REVOLUTIONARY ASPECT0030-96482411-8842https://doaj.org/article/99ac54f6dad5493b9aeacc56d1d41bc42020-09-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/3419/2394https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To assess the gastroprotective effect of montelukast on aspirin induced gastric mucosal ulceration in rabbits. Study Design: Laboratory based quasi experimental study. Place and Duration of Study: National Institute of Health Islamabad and department of Pharmacology and Therapeutics in collaboration with Histopathology department at Army Medical College Rawalpindi from March to May 2018. Methodology: Twenty eight New Zealand white rabbits were randomly divided into four groups as follows: Group 1 was normal control group, group 2 received aspirin as a single dose of 300mg/kg orally on day 6 of the study, group 3 and 4 received omeprazole and montelukast respectively on a similar dosing schedule: where a total of 10mg/kg/day of each respective drug was administered orally for 6 consecutive days followed by a single oral dose of 300 mg/kg of aspirin after 1 hour of the last dose. All animals were sacrificed 5 hours after aspirin administration. The abdomens were dissected and the gastric tissues were excised for macroscopic, ulcer index and pH evaluation and were sent for histopathology for microscopic assessment. Results: Moderate to severe gastric mucosal damage (grade II-III) was seen in the aspirin treated toxic group, with considerable increase in ulcer index and decrease in pH (p<0.001). Montelukast significantly ameliorated the gastric mucosal ulceration as evident by substantial decrease in ulcer index (UI), increase in pH, gross and histoarchitecture findings with preventive index of 51.36% closed to the percentage protection of standard antiulcer drug omeprazole. Conclusions: Montelukast has anti-ulcerogenic gastroprotective effect on microscopic, macroscopic and biochemical level.Syeda Urooj ZaidiMuhammad Waqar Aslam KhanSumetha YaseenMahwish GulZubaida RashidMaryam SaqibArmy Medical College RawalpindiarticleaspiringastroprotectionmontelukastomeprazoleMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 69, Iss 5, Pp 1088-1093 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	aspirin gastroprotection montelukast omeprazole Medicine R Medicine (General) R5-920
spellingShingle	aspirin gastroprotection montelukast omeprazole Medicine R Medicine (General) R5-920 Syeda Urooj Zaidi Muhammad Waqar Aslam Khan Sumetha Yaseen Mahwish Gul Zubaida Rashid Maryam Saqib NOVEL PROTECTIVE ROLE OF MONTELUKAST AGAINST ASPIRIN INDUCED GASTRIC ULCERATION IN RABBITS - MONTELUKAST; A REVOLUTIONARY ASPECT
description	Objective: To assess the gastroprotective effect of montelukast on aspirin induced gastric mucosal ulceration in rabbits. Study Design: Laboratory based quasi experimental study. Place and Duration of Study: National Institute of Health Islamabad and department of Pharmacology and Therapeutics in collaboration with Histopathology department at Army Medical College Rawalpindi from March to May 2018. Methodology: Twenty eight New Zealand white rabbits were randomly divided into four groups as follows: Group 1 was normal control group, group 2 received aspirin as a single dose of 300mg/kg orally on day 6 of the study, group 3 and 4 received omeprazole and montelukast respectively on a similar dosing schedule: where a total of 10mg/kg/day of each respective drug was administered orally for 6 consecutive days followed by a single oral dose of 300 mg/kg of aspirin after 1 hour of the last dose. All animals were sacrificed 5 hours after aspirin administration. The abdomens were dissected and the gastric tissues were excised for macroscopic, ulcer index and pH evaluation and were sent for histopathology for microscopic assessment. Results: Moderate to severe gastric mucosal damage (grade II-III) was seen in the aspirin treated toxic group, with considerable increase in ulcer index and decrease in pH (p<0.001). Montelukast significantly ameliorated the gastric mucosal ulceration as evident by substantial decrease in ulcer index (UI), increase in pH, gross and histoarchitecture findings with preventive index of 51.36% closed to the percentage protection of standard antiulcer drug omeprazole. Conclusions: Montelukast has anti-ulcerogenic gastroprotective effect on microscopic, macroscopic and biochemical level.
format	article
author	Syeda Urooj Zaidi Muhammad Waqar Aslam Khan Sumetha Yaseen Mahwish Gul Zubaida Rashid Maryam Saqib
author_facet	Syeda Urooj Zaidi Muhammad Waqar Aslam Khan Sumetha Yaseen Mahwish Gul Zubaida Rashid Maryam Saqib
author_sort	Syeda Urooj Zaidi
title	NOVEL PROTECTIVE ROLE OF MONTELUKAST AGAINST ASPIRIN INDUCED GASTRIC ULCERATION IN RABBITS - MONTELUKAST; A REVOLUTIONARY ASPECT
title_short	NOVEL PROTECTIVE ROLE OF MONTELUKAST AGAINST ASPIRIN INDUCED GASTRIC ULCERATION IN RABBITS - MONTELUKAST; A REVOLUTIONARY ASPECT
title_full	NOVEL PROTECTIVE ROLE OF MONTELUKAST AGAINST ASPIRIN INDUCED GASTRIC ULCERATION IN RABBITS - MONTELUKAST; A REVOLUTIONARY ASPECT
title_fullStr	NOVEL PROTECTIVE ROLE OF MONTELUKAST AGAINST ASPIRIN INDUCED GASTRIC ULCERATION IN RABBITS - MONTELUKAST; A REVOLUTIONARY ASPECT
title_full_unstemmed	NOVEL PROTECTIVE ROLE OF MONTELUKAST AGAINST ASPIRIN INDUCED GASTRIC ULCERATION IN RABBITS - MONTELUKAST; A REVOLUTIONARY ASPECT
title_sort	novel protective role of montelukast against aspirin induced gastric ulceration in rabbits - montelukast; a revolutionary aspect
publisher	Army Medical College Rawalpindi
publishDate	2020
url	https://doaj.org/article/99ac54f6dad5493b9aeacc56d1d41bc4
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NOVEL PROTECTIVE ROLE OF MONTELUKAST AGAINST ASPIRIN INDUCED GASTRIC ULCERATION IN RABBITS - MONTELUKAST; A REVOLUTIONARY ASPECT

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