Association Between Adipose Tissue Characteristics and Metabolic Flexibility in Humans: A Systematic Review

Adipose tissue total amount, distribution, and phenotype influence metabolic health. This may be partially mediated by the metabolic effects that these adipose tissue characteristics exert on the nearby and distant tissues. Thus, adipose tissue may influence the capacity of cells, tissues, and the o...

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Autores principales:	Alice Glaves, Francisco Díaz-Castro, Javiera Farías, Rodrigo Ramírez-Romero, Jose E. Galgani, Rodrigo Fernández-Verdejo
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	body composition respiratory quotient metabolic health obesity fuel oxidation Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/99adda170cf44d55a6831ff8e7aa2866
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spelling	oai:doaj.org-article:99adda170cf44d55a6831ff8e7aa28662021-12-03T05:34:49ZAssociation Between Adipose Tissue Characteristics and Metabolic Flexibility in Humans: A Systematic Review2296-861X10.3389/fnut.2021.744187https://doaj.org/article/99adda170cf44d55a6831ff8e7aa28662021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnut.2021.744187/fullhttps://doaj.org/toc/2296-861XAdipose tissue total amount, distribution, and phenotype influence metabolic health. This may be partially mediated by the metabolic effects that these adipose tissue characteristics exert on the nearby and distant tissues. Thus, adipose tissue may influence the capacity of cells, tissues, and the organism to adapt fuel oxidation to fuel availability, i.e., their metabolic flexibility (MetF). Our aim was to systematically review the evidence for an association between adipose tissue characteristics and MetF in response to metabolic challenges in human adults. We searched in PubMed (last search on September 4, 2021) for reports that measured adipose tissue characteristics (total amount, distribution, and phenotype) and MetF in response to metabolic challenges (as a change in respiratory quotient) in humans aged 18 to <65 years. Any study design was considered, and the risk of bias was assessed with a checklist for randomized and non-randomized studies. From 880 records identified, 22 remained for the analysis, 10 of them measured MetF in response to glucose plus insulin stimulation, nine in response to dietary challenges, and four in response to other challenges. Our main findings were that: (a) MetF to glucose plus insulin stimulation seems inversely associated with adipose tissue total amount, waist circumference, and visceral adipose tissue; and (b) MetF to dietary challenges does not seem associated with adipose tissue total amount or distribution. In conclusion, evidence suggests that adipose tissue may directly or indirectly influence MetF to glucose plus insulin stimulation, an effect probably explained by skeletal muscle insulin sensitivity.Systematic Review Registration: PROSPERO [CRD42020167810].Alice GlavesFrancisco Díaz-CastroJaviera FaríasRodrigo Ramírez-RomeroJose E. GalganiJose E. GalganiRodrigo Fernández-VerdejoRodrigo Fernández-VerdejoFrontiers Media S.A.articlebody compositionrespiratory quotientmetabolic healthobesityfuel oxidationNutrition. Foods and food supplyTX341-641ENFrontiers in Nutrition, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	body composition respiratory quotient metabolic health obesity fuel oxidation Nutrition. Foods and food supply TX341-641
spellingShingle	body composition respiratory quotient metabolic health obesity fuel oxidation Nutrition. Foods and food supply TX341-641 Alice Glaves Francisco Díaz-Castro Javiera Farías Rodrigo Ramírez-Romero Jose E. Galgani Jose E. Galgani Rodrigo Fernández-Verdejo Rodrigo Fernández-Verdejo Association Between Adipose Tissue Characteristics and Metabolic Flexibility in Humans: A Systematic Review
description	Adipose tissue total amount, distribution, and phenotype influence metabolic health. This may be partially mediated by the metabolic effects that these adipose tissue characteristics exert on the nearby and distant tissues. Thus, adipose tissue may influence the capacity of cells, tissues, and the organism to adapt fuel oxidation to fuel availability, i.e., their metabolic flexibility (MetF). Our aim was to systematically review the evidence for an association between adipose tissue characteristics and MetF in response to metabolic challenges in human adults. We searched in PubMed (last search on September 4, 2021) for reports that measured adipose tissue characteristics (total amount, distribution, and phenotype) and MetF in response to metabolic challenges (as a change in respiratory quotient) in humans aged 18 to <65 years. Any study design was considered, and the risk of bias was assessed with a checklist for randomized and non-randomized studies. From 880 records identified, 22 remained for the analysis, 10 of them measured MetF in response to glucose plus insulin stimulation, nine in response to dietary challenges, and four in response to other challenges. Our main findings were that: (a) MetF to glucose plus insulin stimulation seems inversely associated with adipose tissue total amount, waist circumference, and visceral adipose tissue; and (b) MetF to dietary challenges does not seem associated with adipose tissue total amount or distribution. In conclusion, evidence suggests that adipose tissue may directly or indirectly influence MetF to glucose plus insulin stimulation, an effect probably explained by skeletal muscle insulin sensitivity.Systematic Review Registration: PROSPERO [CRD42020167810].
format	article
author	Alice Glaves Francisco Díaz-Castro Javiera Farías Rodrigo Ramírez-Romero Jose E. Galgani Jose E. Galgani Rodrigo Fernández-Verdejo Rodrigo Fernández-Verdejo
author_facet	Alice Glaves Francisco Díaz-Castro Javiera Farías Rodrigo Ramírez-Romero Jose E. Galgani Jose E. Galgani Rodrigo Fernández-Verdejo Rodrigo Fernández-Verdejo
author_sort	Alice Glaves
title	Association Between Adipose Tissue Characteristics and Metabolic Flexibility in Humans: A Systematic Review
title_short	Association Between Adipose Tissue Characteristics and Metabolic Flexibility in Humans: A Systematic Review
title_full	Association Between Adipose Tissue Characteristics and Metabolic Flexibility in Humans: A Systematic Review
title_fullStr	Association Between Adipose Tissue Characteristics and Metabolic Flexibility in Humans: A Systematic Review
title_full_unstemmed	Association Between Adipose Tissue Characteristics and Metabolic Flexibility in Humans: A Systematic Review
title_sort	association between adipose tissue characteristics and metabolic flexibility in humans: a systematic review
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/99adda170cf44d55a6831ff8e7aa2866
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Association Between Adipose Tissue Characteristics and Metabolic Flexibility in Humans: A Systematic Review

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