Real-time threshold determination of auditory brainstem responses by cross-correlation analysis

Summary: Auditory brainstem response (ABR) serves as an objective indication of auditory perception at a given sound level and is nowadays widely used in hearing function assessment. Despite efforts for automation over decades, ABR threshold determination by machine algorithms remains unreliable and...

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Autores principales: Haoyu Wang, Bei Li, Yan Lu, Kun Han, Haibin Sheng, Jialei Zhou, Yumeng Qi, Xueling Wang, Zhiwu Huang, Lei Song, Yunfeng Hua
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Lenguaje:EN
Publicado: Elsevier 2021
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Acceso en línea:https://doaj.org/article/99af61d17f444fe59d5540516bf6b784
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spelling oai:doaj.org-article:99af61d17f444fe59d5540516bf6b7842021-11-20T05:09:21ZReal-time threshold determination of auditory brainstem responses by cross-correlation analysis2589-004210.1016/j.isci.2021.103285https://doaj.org/article/99af61d17f444fe59d5540516bf6b7842021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2589004221012542https://doaj.org/toc/2589-0042Summary: Auditory brainstem response (ABR) serves as an objective indication of auditory perception at a given sound level and is nowadays widely used in hearing function assessment. Despite efforts for automation over decades, ABR threshold determination by machine algorithms remains unreliable and thereby one still relies on visual identification by trained personnel. Here, we described a procedure for automatic threshold determination that can be used in both animal and human ABR tests. The method terminates level averaging of ABR recordings upon detection of time-locked waveform through cross-correlation analysis. The threshold level was then indicated by a dramatic increase in the sweep numbers required to produce “qualified” level averaging. A good match was obtained between the algorithm outcome and the human readouts. Moreover, the method varies the level averaging based on the cross-correlation, thereby adapting to the signal-to-noise ratio of sweep recordings. These features empower a robust and fully automated ABR test.Haoyu WangBei LiYan LuKun HanHaibin ShengJialei ZhouYumeng QiXueling WangZhiwu HuangLei SongYunfeng HuaElsevierarticleSensory neuroscienceTechniques in neuroscienceAlgorithmsScienceQENiScience, Vol 24, Iss 11, Pp 103285- (2021)
institution DOAJ
collection DOAJ
language EN
topic Sensory neuroscience
Techniques in neuroscience
Algorithms
Science
Q
spellingShingle Sensory neuroscience
Techniques in neuroscience
Algorithms
Science
Q
Haoyu Wang
Bei Li
Yan Lu
Kun Han
Haibin Sheng
Jialei Zhou
Yumeng Qi
Xueling Wang
Zhiwu Huang
Lei Song
Yunfeng Hua
Real-time threshold determination of auditory brainstem responses by cross-correlation analysis
description Summary: Auditory brainstem response (ABR) serves as an objective indication of auditory perception at a given sound level and is nowadays widely used in hearing function assessment. Despite efforts for automation over decades, ABR threshold determination by machine algorithms remains unreliable and thereby one still relies on visual identification by trained personnel. Here, we described a procedure for automatic threshold determination that can be used in both animal and human ABR tests. The method terminates level averaging of ABR recordings upon detection of time-locked waveform through cross-correlation analysis. The threshold level was then indicated by a dramatic increase in the sweep numbers required to produce “qualified” level averaging. A good match was obtained between the algorithm outcome and the human readouts. Moreover, the method varies the level averaging based on the cross-correlation, thereby adapting to the signal-to-noise ratio of sweep recordings. These features empower a robust and fully automated ABR test.
format article
author Haoyu Wang
Bei Li
Yan Lu
Kun Han
Haibin Sheng
Jialei Zhou
Yumeng Qi
Xueling Wang
Zhiwu Huang
Lei Song
Yunfeng Hua
author_facet Haoyu Wang
Bei Li
Yan Lu
Kun Han
Haibin Sheng
Jialei Zhou
Yumeng Qi
Xueling Wang
Zhiwu Huang
Lei Song
Yunfeng Hua
author_sort Haoyu Wang
title Real-time threshold determination of auditory brainstem responses by cross-correlation analysis
title_short Real-time threshold determination of auditory brainstem responses by cross-correlation analysis
title_full Real-time threshold determination of auditory brainstem responses by cross-correlation analysis
title_fullStr Real-time threshold determination of auditory brainstem responses by cross-correlation analysis
title_full_unstemmed Real-time threshold determination of auditory brainstem responses by cross-correlation analysis
title_sort real-time threshold determination of auditory brainstem responses by cross-correlation analysis
publisher Elsevier
publishDate 2021
url https://doaj.org/article/99af61d17f444fe59d5540516bf6b784
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