Maternal plasma miRNAs as biomarkers during mid-pregnancy to predict later spontaneous preterm birth: a pilot study

Abstract More than 10% of babies are born too early resulting in over 15 million preterm births and more than one million new-born deaths globally. Although women with a previous spontaneous preterm birth (SPTB) are considered at high risk for recurrence, the majority occur in women without prior hi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Clint Gray, Lesley M. McCowan, Rachna Patel, Rennae S. Taylor, Mark H. Vickers
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/99b47d649112468a9612024b6f1e7043
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:99b47d649112468a9612024b6f1e7043
record_format	dspace
spelling	oai:doaj.org-article:99b47d649112468a9612024b6f1e70432021-12-02T15:05:22ZMaternal plasma miRNAs as biomarkers during mid-pregnancy to predict later spontaneous preterm birth: a pilot study10.1038/s41598-017-00713-82045-2322https://doaj.org/article/99b47d649112468a9612024b6f1e70432017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00713-8https://doaj.org/toc/2045-2322Abstract More than 10% of babies are born too early resulting in over 15 million preterm births and more than one million new-born deaths globally. Although women with a previous spontaneous preterm birth (SPTB) are considered at high risk for recurrence, the majority occur in women without prior history. Prediction of SPTB risk allows for improved care and potential for targeting novel and existing therapeutics to prevent SPTB, which may result in improved outcomes for infant and mother. In this pilot study, a miRNA array was used to analyse plasma from healthy women in their first pregnancy at 20 weeks of gestation who then went on to deliver either at term or experience SPTB at 28–32 weeks. We identified specific miRNA expression profiles that differentiated between those mothers who delivered at term or delivered following SPTB. miR302b, miR1253 and a clustering of miR548 miRNAs were underexpressed in SPTB cases compared to term controls. Conversely, miR223 was elevated in mothers that later experienced a SPTB. The circulating miRNAs identified in the present study may therefore be attractive candidates as non-invasive biomarkers for the early prediction of SPTB. Further larger studies are now warranted to investigate the potential clinical utility of these markers.Clint GrayLesley M. McCowanRachna PatelRennae S. TaylorMark H. VickersNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Clint Gray Lesley M. McCowan Rachna Patel Rennae S. Taylor Mark H. Vickers Maternal plasma miRNAs as biomarkers during mid-pregnancy to predict later spontaneous preterm birth: a pilot study
description	Abstract More than 10% of babies are born too early resulting in over 15 million preterm births and more than one million new-born deaths globally. Although women with a previous spontaneous preterm birth (SPTB) are considered at high risk for recurrence, the majority occur in women without prior history. Prediction of SPTB risk allows for improved care and potential for targeting novel and existing therapeutics to prevent SPTB, which may result in improved outcomes for infant and mother. In this pilot study, a miRNA array was used to analyse plasma from healthy women in their first pregnancy at 20 weeks of gestation who then went on to deliver either at term or experience SPTB at 28–32 weeks. We identified specific miRNA expression profiles that differentiated between those mothers who delivered at term or delivered following SPTB. miR302b, miR1253 and a clustering of miR548 miRNAs were underexpressed in SPTB cases compared to term controls. Conversely, miR223 was elevated in mothers that later experienced a SPTB. The circulating miRNAs identified in the present study may therefore be attractive candidates as non-invasive biomarkers for the early prediction of SPTB. Further larger studies are now warranted to investigate the potential clinical utility of these markers.
format	article
author	Clint Gray Lesley M. McCowan Rachna Patel Rennae S. Taylor Mark H. Vickers
author_facet	Clint Gray Lesley M. McCowan Rachna Patel Rennae S. Taylor Mark H. Vickers
author_sort	Clint Gray
title	Maternal plasma miRNAs as biomarkers during mid-pregnancy to predict later spontaneous preterm birth: a pilot study
title_short	Maternal plasma miRNAs as biomarkers during mid-pregnancy to predict later spontaneous preterm birth: a pilot study
title_full	Maternal plasma miRNAs as biomarkers during mid-pregnancy to predict later spontaneous preterm birth: a pilot study
title_fullStr	Maternal plasma miRNAs as biomarkers during mid-pregnancy to predict later spontaneous preterm birth: a pilot study
title_full_unstemmed	Maternal plasma miRNAs as biomarkers during mid-pregnancy to predict later spontaneous preterm birth: a pilot study
title_sort	maternal plasma mirnas as biomarkers during mid-pregnancy to predict later spontaneous preterm birth: a pilot study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/99b47d649112468a9612024b6f1e7043
work_keys_str_mv	AT clintgray maternalplasmamirnasasbiomarkersduringmidpregnancytopredictlaterspontaneouspretermbirthapilotstudy AT lesleymmccowan maternalplasmamirnasasbiomarkersduringmidpregnancytopredictlaterspontaneouspretermbirthapilotstudy AT rachnapatel maternalplasmamirnasasbiomarkersduringmidpregnancytopredictlaterspontaneouspretermbirthapilotstudy AT rennaestaylor maternalplasmamirnasasbiomarkersduringmidpregnancytopredictlaterspontaneouspretermbirthapilotstudy AT markhvickers maternalplasmamirnasasbiomarkersduringmidpregnancytopredictlaterspontaneouspretermbirthapilotstudy
_version_	1718388848159883264

Maternal plasma miRNAs as biomarkers during mid-pregnancy to predict later spontaneous preterm birth: a pilot study

Ejemplares similares