Aptazyme-embedded guide RNAs enable ligand-responsive genome editing and transcriptional activation

CRISPR-Cas9 is a powerful technique for manipulating the human genome, however temporal and spatial control of activity would facilitate safer, more selective use. Here the authors incorporate aptazymes into guide RNAs to allow small molecule activation of CRISPR-Cas9.

Guardado en:
Detalles Bibliográficos
Autores principales: Weixin Tang, Johnny H. Hu, David R. Liu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Q
Acceso en línea:https://doaj.org/article/99b6d665d5524fc89acbd0b21587a335
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares