Locally anchoring enzymes to tissues via extracellular glycan recognition

The use of enzymes as drugs requires that they persist within target tissues over therapeutically relevant time frames. Here the authors use a galectin-3 fusion to anchor enzymes at injection sites for up to 14 days.

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Autores principales:	Shaheen A. Farhadi, Evelyn Bracho-Sanchez, Margaret M. Fettis, Dillon T. Seroski, Sabrina L. Freeman, Antonietta Restuccia, Benjamin G. Keselowsky, Gregory A. Hudalla
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/99b77a528cc74b09b0fb7568fbf3a3a5
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spelling	oai:doaj.org-article:99b77a528cc74b09b0fb7568fbf3a3a52021-12-02T14:39:26ZLocally anchoring enzymes to tissues via extracellular glycan recognition10.1038/s41467-018-07129-62041-1723https://doaj.org/article/99b77a528cc74b09b0fb7568fbf3a3a52018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07129-6https://doaj.org/toc/2041-1723The use of enzymes as drugs requires that they persist within target tissues over therapeutically relevant time frames. Here the authors use a galectin-3 fusion to anchor enzymes at injection sites for up to 14 days.Shaheen A. FarhadiEvelyn Bracho-SanchezMargaret M. FettisDillon T. SeroskiSabrina L. FreemanAntonietta RestucciaBenjamin G. KeselowskyGregory A. HudallaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shaheen A. Farhadi Evelyn Bracho-Sanchez Margaret M. Fettis Dillon T. Seroski Sabrina L. Freeman Antonietta Restuccia Benjamin G. Keselowsky Gregory A. Hudalla Locally anchoring enzymes to tissues via extracellular glycan recognition
description	The use of enzymes as drugs requires that they persist within target tissues over therapeutically relevant time frames. Here the authors use a galectin-3 fusion to anchor enzymes at injection sites for up to 14 days.
format	article
author	Shaheen A. Farhadi Evelyn Bracho-Sanchez Margaret M. Fettis Dillon T. Seroski Sabrina L. Freeman Antonietta Restuccia Benjamin G. Keselowsky Gregory A. Hudalla
author_facet	Shaheen A. Farhadi Evelyn Bracho-Sanchez Margaret M. Fettis Dillon T. Seroski Sabrina L. Freeman Antonietta Restuccia Benjamin G. Keselowsky Gregory A. Hudalla
author_sort	Shaheen A. Farhadi
title	Locally anchoring enzymes to tissues via extracellular glycan recognition
title_short	Locally anchoring enzymes to tissues via extracellular glycan recognition
title_full	Locally anchoring enzymes to tissues via extracellular glycan recognition
title_fullStr	Locally anchoring enzymes to tissues via extracellular glycan recognition
title_full_unstemmed	Locally anchoring enzymes to tissues via extracellular glycan recognition
title_sort	locally anchoring enzymes to tissues via extracellular glycan recognition
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/99b77a528cc74b09b0fb7568fbf3a3a5
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Locally anchoring enzymes to tissues via extracellular glycan recognition

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