Squamous cell papilloma of the conjunctiva due to human papillomavirus (HPV): presentation of two cases and review of literature

Chris Kalogeropoulos,1 Ioannis Koumpoulis,1 Evangelos Papadiotis,2 Aikaterini Zioga,2 Konstantina Gkrepi,2 Chrisavgi Pappa,1 Constantinos Paschides,1 Vasiliki Malamou-Mitsi,2 Miltiadis Aspiotis11Department of Ophthalmology, 2Department of Pathology, Medical School, University of Ioannina, GreecePurp...

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Autores principales:	Kalogeropoulos C, Koumpoulis I, Papadiotis E, Zioga A, Gkrepi K, Pappa C, Paschides C, Malamou-Mitsi V, Aspiotis M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/99bb358a09e64f9bbe67da40a45f1373
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spelling	oai:doaj.org-article:99bb358a09e64f9bbe67da40a45f13732021-12-02T00:25:15ZSquamous cell papilloma of the conjunctiva due to human papillomavirus (HPV): presentation of two cases and review of literature1177-54671177-5483https://doaj.org/article/99bb358a09e64f9bbe67da40a45f13732012-09-01T00:00:00Zhttp://www.dovepress.com/squamous-cell-papilloma-of-the-conjunctiva-due-to-human-papillomavirus-a11091https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Chris Kalogeropoulos,1 Ioannis Koumpoulis,1 Evangelos Papadiotis,2 Aikaterini Zioga,2 Konstantina Gkrepi,2 Chrisavgi Pappa,1 Constantinos Paschides,1 Vasiliki Malamou-Mitsi,2 Miltiadis Aspiotis11Department of Ophthalmology, 2Department of Pathology, Medical School, University of Ioannina, GreecePurpose: We describe two patients with squamous cell papilloma of the conjunctiva due to human papilloma virus (HPV) and review the literature.Patients and methods: Two patients with conjunctival tumors were examined and treated in the University Eye Clinic and diagnosed in the University Pathology Department, University Hospital of Ioannina, Greece. The first patient was a 48-year-old man presenting with an extended papillomatous lesion in bulbar conjunctiva covering part of the cornea of his right eye. The second patient was a 24-year-old man presenting with a polypoidal papillomatous lesion on the caruncle of his right eye. The two lesions were removed surgically, cryotherapy was applied to the adjacent conjunctiva, and topical mitomycin-C was used. The amniotic membrane was used to restore the conjunctival defect in the first patient. The two removed lesions were sent to the Pathology Department for histopathological examination. Immunohistochemistry, DNA in situ hybridization, and polymerase chain reaction (PCR) analysis were performed.Results: In the first patient, histopathology showed the presence of a benign squamous papilloma with koilocytosis. DNA in situ hybridization with broad-spectrum probes showed that this patient was positive for HPV DNA. In the second patient, histopathology showed the presence of a squamous papilloma with mild dysplasia and koilocytosis. Immunohistochemical analysis was positive for HPV protein and p16 protein. DNA in situ hybridization with broad-spectrum probes showed that the patient was positive for HPV DNA. PCR analysis showed the presence of HPV 6. According to morphological and molecular findings, both patients were diagnosed with squamous cell papilloma due to HPV.Conclusion: HPV can infect the ocular surface. According to clinical results, the ophthalmologist in cooperation with the pathologist can recommend appropriate laboratory examinations to confirm the diagnosis and successfully treat conjunctival papillomas.Keywords: conjunctiva, papilloma, human papillomavirus, koilocytosis, in situ hybridization, polymerase chain reactionKalogeropoulos CKoumpoulis IPapadiotis EZioga AGkrepi KPappa CPaschides CMalamou-Mitsi VAspiotis MDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2012, Iss default, Pp 1553-1561 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Kalogeropoulos C Koumpoulis I Papadiotis E Zioga A Gkrepi K Pappa C Paschides C Malamou-Mitsi V Aspiotis M Squamous cell papilloma of the conjunctiva due to human papillomavirus (HPV): presentation of two cases and review of literature
description	Chris Kalogeropoulos,1 Ioannis Koumpoulis,1 Evangelos Papadiotis,2 Aikaterini Zioga,2 Konstantina Gkrepi,2 Chrisavgi Pappa,1 Constantinos Paschides,1 Vasiliki Malamou-Mitsi,2 Miltiadis Aspiotis11Department of Ophthalmology, 2Department of Pathology, Medical School, University of Ioannina, GreecePurpose: We describe two patients with squamous cell papilloma of the conjunctiva due to human papilloma virus (HPV) and review the literature.Patients and methods: Two patients with conjunctival tumors were examined and treated in the University Eye Clinic and diagnosed in the University Pathology Department, University Hospital of Ioannina, Greece. The first patient was a 48-year-old man presenting with an extended papillomatous lesion in bulbar conjunctiva covering part of the cornea of his right eye. The second patient was a 24-year-old man presenting with a polypoidal papillomatous lesion on the caruncle of his right eye. The two lesions were removed surgically, cryotherapy was applied to the adjacent conjunctiva, and topical mitomycin-C was used. The amniotic membrane was used to restore the conjunctival defect in the first patient. The two removed lesions were sent to the Pathology Department for histopathological examination. Immunohistochemistry, DNA in situ hybridization, and polymerase chain reaction (PCR) analysis were performed.Results: In the first patient, histopathology showed the presence of a benign squamous papilloma with koilocytosis. DNA in situ hybridization with broad-spectrum probes showed that this patient was positive for HPV DNA. In the second patient, histopathology showed the presence of a squamous papilloma with mild dysplasia and koilocytosis. Immunohistochemical analysis was positive for HPV protein and p16 protein. DNA in situ hybridization with broad-spectrum probes showed that the patient was positive for HPV DNA. PCR analysis showed the presence of HPV 6. According to morphological and molecular findings, both patients were diagnosed with squamous cell papilloma due to HPV.Conclusion: HPV can infect the ocular surface. According to clinical results, the ophthalmologist in cooperation with the pathologist can recommend appropriate laboratory examinations to confirm the diagnosis and successfully treat conjunctival papillomas.Keywords: conjunctiva, papilloma, human papillomavirus, koilocytosis, in situ hybridization, polymerase chain reaction
format	article
author	Kalogeropoulos C Koumpoulis I Papadiotis E Zioga A Gkrepi K Pappa C Paschides C Malamou-Mitsi V Aspiotis M
author_facet	Kalogeropoulos C Koumpoulis I Papadiotis E Zioga A Gkrepi K Pappa C Paschides C Malamou-Mitsi V Aspiotis M
author_sort	Kalogeropoulos C
title	Squamous cell papilloma of the conjunctiva due to human papillomavirus (HPV): presentation of two cases and review of literature
title_short	Squamous cell papilloma of the conjunctiva due to human papillomavirus (HPV): presentation of two cases and review of literature
title_full	Squamous cell papilloma of the conjunctiva due to human papillomavirus (HPV): presentation of two cases and review of literature
title_fullStr	Squamous cell papilloma of the conjunctiva due to human papillomavirus (HPV): presentation of two cases and review of literature
title_full_unstemmed	Squamous cell papilloma of the conjunctiva due to human papillomavirus (HPV): presentation of two cases and review of literature
title_sort	squamous cell papilloma of the conjunctiva due to human papillomavirus (hpv): presentation of two cases and review of literature
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/99bb358a09e64f9bbe67da40a45f1373
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Squamous cell papilloma of the conjunctiva due to human papillomavirus (HPV): presentation of two cases and review of literature

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