A human endothelial cell-based recycling assay for screening of FcRn targeted molecules
The development of IgG and albumin-based therapeutics with increased half-lives needs more efficient screening procedures. Here the authors report a human endothelial cell-based recycling assay enabling screening of IgG and albumin variants without chemical labelling and prior to animal testing.
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| Lenguaje: | EN |
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Nature Portfolio
2018
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| Acceso en línea: | https://doaj.org/article/99bc76e2016a473a870d99a7c561cd47 |
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oai:doaj.org-article:99bc76e2016a473a870d99a7c561cd472021-12-02T15:34:04ZA human endothelial cell-based recycling assay for screening of FcRn targeted molecules10.1038/s41467-018-03061-x2041-1723https://doaj.org/article/99bc76e2016a473a870d99a7c561cd472018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03061-xhttps://doaj.org/toc/2041-1723The development of IgG and albumin-based therapeutics with increased half-lives needs more efficient screening procedures. Here the authors report a human endothelial cell-based recycling assay enabling screening of IgG and albumin variants without chemical labelling and prior to animal testing.Algirdas GrevysJeannette NilsenKine M. K. SandMuluneh B. DabaInger ØynebråtenMalin BernMartin B. McAdamStian FossTilman SchlothauerTerje E. MichaelsenGregory J. ChristiansonDerry C. RoopenianRichard S. BlumbergInger SandlieJan Terje AndersenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018) |
| institution |
DOAJ |
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DOAJ |
| language |
EN |
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Science Q |
| spellingShingle |
Science Q Algirdas Grevys Jeannette Nilsen Kine M. K. Sand Muluneh B. Daba Inger Øynebråten Malin Bern Martin B. McAdam Stian Foss Tilman Schlothauer Terje E. Michaelsen Gregory J. Christianson Derry C. Roopenian Richard S. Blumberg Inger Sandlie Jan Terje Andersen A human endothelial cell-based recycling assay for screening of FcRn targeted molecules |
| description |
The development of IgG and albumin-based therapeutics with increased half-lives needs more efficient screening procedures. Here the authors report a human endothelial cell-based recycling assay enabling screening of IgG and albumin variants without chemical labelling and prior to animal testing. |
| format |
article |
| author |
Algirdas Grevys Jeannette Nilsen Kine M. K. Sand Muluneh B. Daba Inger Øynebråten Malin Bern Martin B. McAdam Stian Foss Tilman Schlothauer Terje E. Michaelsen Gregory J. Christianson Derry C. Roopenian Richard S. Blumberg Inger Sandlie Jan Terje Andersen |
| author_facet |
Algirdas Grevys Jeannette Nilsen Kine M. K. Sand Muluneh B. Daba Inger Øynebråten Malin Bern Martin B. McAdam Stian Foss Tilman Schlothauer Terje E. Michaelsen Gregory J. Christianson Derry C. Roopenian Richard S. Blumberg Inger Sandlie Jan Terje Andersen |
| author_sort |
Algirdas Grevys |
| title |
A human endothelial cell-based recycling assay for screening of FcRn targeted molecules |
| title_short |
A human endothelial cell-based recycling assay for screening of FcRn targeted molecules |
| title_full |
A human endothelial cell-based recycling assay for screening of FcRn targeted molecules |
| title_fullStr |
A human endothelial cell-based recycling assay for screening of FcRn targeted molecules |
| title_full_unstemmed |
A human endothelial cell-based recycling assay for screening of FcRn targeted molecules |
| title_sort |
human endothelial cell-based recycling assay for screening of fcrn targeted molecules |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/99bc76e2016a473a870d99a7c561cd47 |
| work_keys_str_mv |
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