Potential role of stem cells in severe spinal cord injury: current perspectives and clinical data

Syed AB Paspala,1,2 Sandeep K Vishwakarma,1 Tenneti VRK Murthy,2 Thiriveedi N Rao,2 Aleem A Khan11PAN Research Foundation, CARE, 2The Institute of Medical Sciences, Hyderabad, IndiaAbstract: Stem cell transplantation for spinal cord injury (SCI) along with new pharmacotherapy research offers the pot...

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Autores principales:	Paspala SA, Vishwakarma SK, Murthy TV, Rao TN, Khan AA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Cytology QH573-671
Acceso en línea:	https://doaj.org/article/99bd39893cea4abca2e96ccceebd1e0d
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spelling	oai:doaj.org-article:99bd39893cea4abca2e96ccceebd1e0d2021-12-02T02:07:46ZPotential role of stem cells in severe spinal cord injury: current perspectives and clinical data1178-6957https://doaj.org/article/99bd39893cea4abca2e96ccceebd1e0d2012-09-01T00:00:00Zhttp://www.dovepress.com/potential-role-of-stem-cells-in-severe-spinal-cord-injury-current-pers-a11104https://doaj.org/toc/1178-6957Syed AB Paspala,1,2 Sandeep K Vishwakarma,1 Tenneti VRK Murthy,2 Thiriveedi N Rao,2 Aleem A Khan11PAN Research Foundation, CARE, 2The Institute of Medical Sciences, Hyderabad, IndiaAbstract: Stem cell transplantation for spinal cord injury (SCI) along with new pharmacotherapy research offers the potential to restore function and ease the associated social and economic burden in the years ahead. Various sources of stem cells have been used in the treatment of SCI, but the most convincing results have been obtained with neural progenitor cells in preclinical models. Although the use of cell-based transplantation strategies for the repair of chronic SCI remains the long sought after holy grail, these approaches have been to date the most successful when applied in the subacute phase of injury. Application of cell-based strategies for the repair and regeneration of the chronically injured spinal cord will require a combinational strategy that may need to include approaches to overcome the effects of the glial scar, inhibitory molecules, and use of tissue engineering strategies to bridge the lesion. Nonetheless, cell transplantation strategies are promising, and it is anticipated that the Phase I clinical trials of some form of neural stem cell-based approach in SCI will commence very soon.Keywords: stem cell therapy, regeneration, spinal cord injury, cell dosing, cell trackingPaspala SAVishwakarma SKMurthy TVRao TNKhan AADove Medical PressarticleCytologyQH573-671ENStem Cells and Cloning: Advances and Applications, Vol 2012, Iss default, Pp 15-27 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cytology QH573-671
spellingShingle	Cytology QH573-671 Paspala SA Vishwakarma SK Murthy TV Rao TN Khan AA Potential role of stem cells in severe spinal cord injury: current perspectives and clinical data
description	Syed AB Paspala,1,2 Sandeep K Vishwakarma,1 Tenneti VRK Murthy,2 Thiriveedi N Rao,2 Aleem A Khan11PAN Research Foundation, CARE, 2The Institute of Medical Sciences, Hyderabad, IndiaAbstract: Stem cell transplantation for spinal cord injury (SCI) along with new pharmacotherapy research offers the potential to restore function and ease the associated social and economic burden in the years ahead. Various sources of stem cells have been used in the treatment of SCI, but the most convincing results have been obtained with neural progenitor cells in preclinical models. Although the use of cell-based transplantation strategies for the repair of chronic SCI remains the long sought after holy grail, these approaches have been to date the most successful when applied in the subacute phase of injury. Application of cell-based strategies for the repair and regeneration of the chronically injured spinal cord will require a combinational strategy that may need to include approaches to overcome the effects of the glial scar, inhibitory molecules, and use of tissue engineering strategies to bridge the lesion. Nonetheless, cell transplantation strategies are promising, and it is anticipated that the Phase I clinical trials of some form of neural stem cell-based approach in SCI will commence very soon.Keywords: stem cell therapy, regeneration, spinal cord injury, cell dosing, cell tracking
format	article
author	Paspala SA Vishwakarma SK Murthy TV Rao TN Khan AA
author_facet	Paspala SA Vishwakarma SK Murthy TV Rao TN Khan AA
author_sort	Paspala SA
title	Potential role of stem cells in severe spinal cord injury: current perspectives and clinical data
title_short	Potential role of stem cells in severe spinal cord injury: current perspectives and clinical data
title_full	Potential role of stem cells in severe spinal cord injury: current perspectives and clinical data
title_fullStr	Potential role of stem cells in severe spinal cord injury: current perspectives and clinical data
title_full_unstemmed	Potential role of stem cells in severe spinal cord injury: current perspectives and clinical data
title_sort	potential role of stem cells in severe spinal cord injury: current perspectives and clinical data
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/99bd39893cea4abca2e96ccceebd1e0d
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Potential role of stem cells in severe spinal cord injury: current perspectives and clinical data

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