Posttraumatic stress disorder and not depression is associated with shorter leukocyte telomere length: findings from 3,000 participants in the population-based KORA F4 study.

<h4>Background</h4>A link between severe mental stress and shorter telomere length (TL) has been suggested. We analysed the impact of Posttraumatic Stress Disorder (PTSD) on TL in the general population and postulated a dose-dependent TL association in subjects suffering from partial PTS...

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Autores principales:	Karl-Heinz Ladwig, Anne Catharina Brockhaus, Jens Baumert, Karoline Lukaschek, Rebecca T Emeny, Johannes Kruse, Veryan Codd, Sibylle Häfner, Eva Albrecht, Thomas Illig, Nilesh J Samani, H Erich Wichmann, Christian Gieger, Annette Peters
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/99bdadb0210b46e88ed47800e288227f
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spelling	oai:doaj.org-article:99bdadb0210b46e88ed47800e288227f2021-11-18T07:38:54ZPosttraumatic stress disorder and not depression is associated with shorter leukocyte telomere length: findings from 3,000 participants in the population-based KORA F4 study.1932-620310.1371/journal.pone.0064762https://doaj.org/article/99bdadb0210b46e88ed47800e288227f2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23843935/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>A link between severe mental stress and shorter telomere length (TL) has been suggested. We analysed the impact of Posttraumatic Stress Disorder (PTSD) on TL in the general population and postulated a dose-dependent TL association in subjects suffering from partial PTSD compared to full PTSD.<h4>Methods</h4>Data are derived from the population-based KORA F4 study (2006-2008), located in southern Germany including 3,000 individuals (1,449 men and 1,551 women) with valid and complete TL data. Leukocyte TL was measured using a quantitative PCR-based technique. PTSD was assessed in a structured interview and by applying the Posttraumatic Diagnostic Scale (PDS) and the Impact of Event Scale (IES). A total of 262 (8.7%) subjects qualified for having partial PTSD and 51 (1.7%) for full PTSD. To assess the association of PTSD with the average TL, linear regression analyses with adjustments for potential confounding factors were performed.<h4>Results</h4>The multiple model revealed a significant association between partial PTSD and TL (beta = -0.051, p = 0.009) as well as between full PTSD and shorter TL (beta = -0.103, p = 0.014) indicating shorter TL on average for partial and full PTSD. An additional adjustment for depression and depressed mood/exhaustion gave comparable beta estimations.<h4>Conclusions</h4>Participants with partial and full PTSD had significantly shorter leukocyte TL than participants without PTSD. The dose-dependent variation in TL of subjects with partial and full PTSD exceeded the chronological age effect, and was equivalent to an estimated 5 years in partial and 10 years in full PTSD of premature aging.Karl-Heinz LadwigAnne Catharina BrockhausJens BaumertKaroline LukaschekRebecca T EmenyJohannes KruseVeryan CoddSibylle HäfnerEva AlbrechtThomas IlligNilesh J SamaniH Erich WichmannChristian GiegerAnnette PetersPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 7, p e64762 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Karl-Heinz Ladwig Anne Catharina Brockhaus Jens Baumert Karoline Lukaschek Rebecca T Emeny Johannes Kruse Veryan Codd Sibylle Häfner Eva Albrecht Thomas Illig Nilesh J Samani H Erich Wichmann Christian Gieger Annette Peters Posttraumatic stress disorder and not depression is associated with shorter leukocyte telomere length: findings from 3,000 participants in the population-based KORA F4 study.
description	<h4>Background</h4>A link between severe mental stress and shorter telomere length (TL) has been suggested. We analysed the impact of Posttraumatic Stress Disorder (PTSD) on TL in the general population and postulated a dose-dependent TL association in subjects suffering from partial PTSD compared to full PTSD.<h4>Methods</h4>Data are derived from the population-based KORA F4 study (2006-2008), located in southern Germany including 3,000 individuals (1,449 men and 1,551 women) with valid and complete TL data. Leukocyte TL was measured using a quantitative PCR-based technique. PTSD was assessed in a structured interview and by applying the Posttraumatic Diagnostic Scale (PDS) and the Impact of Event Scale (IES). A total of 262 (8.7%) subjects qualified for having partial PTSD and 51 (1.7%) for full PTSD. To assess the association of PTSD with the average TL, linear regression analyses with adjustments for potential confounding factors were performed.<h4>Results</h4>The multiple model revealed a significant association between partial PTSD and TL (beta = -0.051, p = 0.009) as well as between full PTSD and shorter TL (beta = -0.103, p = 0.014) indicating shorter TL on average for partial and full PTSD. An additional adjustment for depression and depressed mood/exhaustion gave comparable beta estimations.<h4>Conclusions</h4>Participants with partial and full PTSD had significantly shorter leukocyte TL than participants without PTSD. The dose-dependent variation in TL of subjects with partial and full PTSD exceeded the chronological age effect, and was equivalent to an estimated 5 years in partial and 10 years in full PTSD of premature aging.
format	article
author	Karl-Heinz Ladwig Anne Catharina Brockhaus Jens Baumert Karoline Lukaschek Rebecca T Emeny Johannes Kruse Veryan Codd Sibylle Häfner Eva Albrecht Thomas Illig Nilesh J Samani H Erich Wichmann Christian Gieger Annette Peters
author_facet	Karl-Heinz Ladwig Anne Catharina Brockhaus Jens Baumert Karoline Lukaschek Rebecca T Emeny Johannes Kruse Veryan Codd Sibylle Häfner Eva Albrecht Thomas Illig Nilesh J Samani H Erich Wichmann Christian Gieger Annette Peters
author_sort	Karl-Heinz Ladwig
title	Posttraumatic stress disorder and not depression is associated with shorter leukocyte telomere length: findings from 3,000 participants in the population-based KORA F4 study.
title_short	Posttraumatic stress disorder and not depression is associated with shorter leukocyte telomere length: findings from 3,000 participants in the population-based KORA F4 study.
title_full	Posttraumatic stress disorder and not depression is associated with shorter leukocyte telomere length: findings from 3,000 participants in the population-based KORA F4 study.
title_fullStr	Posttraumatic stress disorder and not depression is associated with shorter leukocyte telomere length: findings from 3,000 participants in the population-based KORA F4 study.
title_full_unstemmed	Posttraumatic stress disorder and not depression is associated with shorter leukocyte telomere length: findings from 3,000 participants in the population-based KORA F4 study.
title_sort	posttraumatic stress disorder and not depression is associated with shorter leukocyte telomere length: findings from 3,000 participants in the population-based kora f4 study.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/99bdadb0210b46e88ed47800e288227f
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Posttraumatic stress disorder and not depression is associated with shorter leukocyte telomere length: findings from 3,000 participants in the population-based KORA F4 study.

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