Epigenetic upregulation of endogenous VEGF-A reduces myocardial infarct size in mice.

Epigenetic upregulation of endogenous VEGF-A reduces myocardial infarct size in mice.

"Epigenetherapy" alters epigenetic status of the targeted chromatin and modifies expression of the endogenous therapeutic gene. In this study we used lentiviral in vivo delivery of small hairpin RNA (shRNA) into hearts in a murine infarction model. shRNA complementary to the promoter of va...

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Main Authors: Mikko P Turunen, Tiia Husso, Haja Musthafa, Svetlana Laidinen, Galina Dragneva, Nihay Laham-Karam, Sanna Honkanen, Anne Paakinaho, Johanna P Laakkonen, Erhe Gao, Maija Vihinen-Ranta, Timo Liimatainen, Seppo Ylä-Herttuala
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2014
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/99c378ad6db04a1ba9c9b3aeb17d77fc
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https://doaj.org/article/99c378ad6db04a1ba9c9b3aeb17d77fc

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