The Correlation Between Thyroid Function, Frontal Gray Matter, and Executive Function in Patients With Major Depressive Disorder
The present study was aimed to investigate the relationships between serum thyroid hormones (THs), frontal gray matter volume, and executive function in selected patients with major depressive disorder (MDD). One hundred and four MDD patients and seventy-five healthy controls (HCs) were subjected to...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:99c68acfec5945beae2a950e04ac00fb2021-11-30T12:02:32ZThe Correlation Between Thyroid Function, Frontal Gray Matter, and Executive Function in Patients With Major Depressive Disorder1664-239210.3389/fendo.2021.779693https://doaj.org/article/99c68acfec5945beae2a950e04ac00fb2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fendo.2021.779693/fullhttps://doaj.org/toc/1664-2392The present study was aimed to investigate the relationships between serum thyroid hormones (THs), frontal gray matter volume, and executive function in selected patients with major depressive disorder (MDD). One hundred and four MDD patients and seventy-five healthy controls (HCs) were subjected to thyroid-stimulating hormone (TSH), free Triiodothyronine (fT3), free Thyroxine (fT4), and executive function tests and underwent structural magnetic resonance imaging (MRI). Voxel-based morphometry (VBM) analysis was performed to compare group differences in the gray matter for the frontal lobe. Furthermore, mediation analysis was used to investigate whether gray matter volumes of the frontal gyrus mediated the relationship between serum THs and executive function in MDD patients. MDD patients exhibited significant gray matter volume reduction in several brain regions, including the left rectus, right middle frontal cortex, and left middle frontal cortex. Serum TSH levels are positively associated with altered regional gray matter volume patterns within MFG and executive function. Importantly, gray matter in the right MFG was a significant mediator between serum TSH levels and executive function. These findings expand our understanding of how thyroid function affects brain structure changes and executive function in MDD patients.Shuai ZhaoYi XiaYinghong HuangHaowen ZouXumiao WangZhilu ChenHongliang ZhouYinglin HanHao TangRui YanZhijian YaoZhijian YaoQing LuQing LuFrontiers Media S.A.articlethyroid hormonesexecutive functiongray matter volumevoxel-based morphometrymagnetic resonance imagingmajor depressive disorderDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENFrontiers in Endocrinology, Vol 12 (2021) |
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thyroid hormones executive function gray matter volume voxel-based morphometry magnetic resonance imaging major depressive disorder Diseases of the endocrine glands. Clinical endocrinology RC648-665 |
| spellingShingle |
thyroid hormones executive function gray matter volume voxel-based morphometry magnetic resonance imaging major depressive disorder Diseases of the endocrine glands. Clinical endocrinology RC648-665 Shuai Zhao Yi Xia Yinghong Huang Haowen Zou Xumiao Wang Zhilu Chen Hongliang Zhou Yinglin Han Hao Tang Rui Yan Zhijian Yao Zhijian Yao Qing Lu Qing Lu The Correlation Between Thyroid Function, Frontal Gray Matter, and Executive Function in Patients With Major Depressive Disorder |
| description |
The present study was aimed to investigate the relationships between serum thyroid hormones (THs), frontal gray matter volume, and executive function in selected patients with major depressive disorder (MDD). One hundred and four MDD patients and seventy-five healthy controls (HCs) were subjected to thyroid-stimulating hormone (TSH), free Triiodothyronine (fT3), free Thyroxine (fT4), and executive function tests and underwent structural magnetic resonance imaging (MRI). Voxel-based morphometry (VBM) analysis was performed to compare group differences in the gray matter for the frontal lobe. Furthermore, mediation analysis was used to investigate whether gray matter volumes of the frontal gyrus mediated the relationship between serum THs and executive function in MDD patients. MDD patients exhibited significant gray matter volume reduction in several brain regions, including the left rectus, right middle frontal cortex, and left middle frontal cortex. Serum TSH levels are positively associated with altered regional gray matter volume patterns within MFG and executive function. Importantly, gray matter in the right MFG was a significant mediator between serum TSH levels and executive function. These findings expand our understanding of how thyroid function affects brain structure changes and executive function in MDD patients. |
| format |
article |
| author |
Shuai Zhao Yi Xia Yinghong Huang Haowen Zou Xumiao Wang Zhilu Chen Hongliang Zhou Yinglin Han Hao Tang Rui Yan Zhijian Yao Zhijian Yao Qing Lu Qing Lu |
| author_facet |
Shuai Zhao Yi Xia Yinghong Huang Haowen Zou Xumiao Wang Zhilu Chen Hongliang Zhou Yinglin Han Hao Tang Rui Yan Zhijian Yao Zhijian Yao Qing Lu Qing Lu |
| author_sort |
Shuai Zhao |
| title |
The Correlation Between Thyroid Function, Frontal Gray Matter, and Executive Function in Patients With Major Depressive Disorder |
| title_short |
The Correlation Between Thyroid Function, Frontal Gray Matter, and Executive Function in Patients With Major Depressive Disorder |
| title_full |
The Correlation Between Thyroid Function, Frontal Gray Matter, and Executive Function in Patients With Major Depressive Disorder |
| title_fullStr |
The Correlation Between Thyroid Function, Frontal Gray Matter, and Executive Function in Patients With Major Depressive Disorder |
| title_full_unstemmed |
The Correlation Between Thyroid Function, Frontal Gray Matter, and Executive Function in Patients With Major Depressive Disorder |
| title_sort |
correlation between thyroid function, frontal gray matter, and executive function in patients with major depressive disorder |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/99c68acfec5945beae2a950e04ac00fb |
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