Transcriptional signatures of schizophrenia in hiPSC-derived NPCs and neurons are concordant with post-mortem adult brains

Induced pluripotent stem cell (hiPSC)-based models have inherent variations in their cellular and molecular output and readouts. Here, Hoffman and colleagues devise a method to account for gene expression variations in hiPSC-derived neurons from patients with childhood-onset schizophrenia.

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Autores principales:	Gabriel E. Hoffman, Brigham J. Hartley, Erin Flaherty, Ian Ladran, Peter Gochman, Douglas M. Ruderfer, Eli A. Stahl, Judith Rapoport, Pamela Sklar, Kristen J. Brennand
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/99c9b01d94b044f2bf2ad26960baaf9f
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spelling	oai:doaj.org-article:99c9b01d94b044f2bf2ad26960baaf9f2021-12-02T14:42:43ZTranscriptional signatures of schizophrenia in hiPSC-derived NPCs and neurons are concordant with post-mortem adult brains10.1038/s41467-017-02330-52041-1723https://doaj.org/article/99c9b01d94b044f2bf2ad26960baaf9f2017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02330-5https://doaj.org/toc/2041-1723Induced pluripotent stem cell (hiPSC)-based models have inherent variations in their cellular and molecular output and readouts. Here, Hoffman and colleagues devise a method to account for gene expression variations in hiPSC-derived neurons from patients with childhood-onset schizophrenia.Gabriel E. HoffmanBrigham J. HartleyErin FlahertyIan LadranPeter GochmanDouglas M. RuderferEli A. StahlJudith RapoportPamela SklarKristen J. BrennandNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gabriel E. Hoffman Brigham J. Hartley Erin Flaherty Ian Ladran Peter Gochman Douglas M. Ruderfer Eli A. Stahl Judith Rapoport Pamela Sklar Kristen J. Brennand Transcriptional signatures of schizophrenia in hiPSC-derived NPCs and neurons are concordant with post-mortem adult brains
description	Induced pluripotent stem cell (hiPSC)-based models have inherent variations in their cellular and molecular output and readouts. Here, Hoffman and colleagues devise a method to account for gene expression variations in hiPSC-derived neurons from patients with childhood-onset schizophrenia.
format	article
author	Gabriel E. Hoffman Brigham J. Hartley Erin Flaherty Ian Ladran Peter Gochman Douglas M. Ruderfer Eli A. Stahl Judith Rapoport Pamela Sklar Kristen J. Brennand
author_facet	Gabriel E. Hoffman Brigham J. Hartley Erin Flaherty Ian Ladran Peter Gochman Douglas M. Ruderfer Eli A. Stahl Judith Rapoport Pamela Sklar Kristen J. Brennand
author_sort	Gabriel E. Hoffman
title	Transcriptional signatures of schizophrenia in hiPSC-derived NPCs and neurons are concordant with post-mortem adult brains
title_short	Transcriptional signatures of schizophrenia in hiPSC-derived NPCs and neurons are concordant with post-mortem adult brains
title_full	Transcriptional signatures of schizophrenia in hiPSC-derived NPCs and neurons are concordant with post-mortem adult brains
title_fullStr	Transcriptional signatures of schizophrenia in hiPSC-derived NPCs and neurons are concordant with post-mortem adult brains
title_full_unstemmed	Transcriptional signatures of schizophrenia in hiPSC-derived NPCs and neurons are concordant with post-mortem adult brains
title_sort	transcriptional signatures of schizophrenia in hipsc-derived npcs and neurons are concordant with post-mortem adult brains
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/99c9b01d94b044f2bf2ad26960baaf9f
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Transcriptional signatures of schizophrenia in hiPSC-derived NPCs and neurons are concordant with post-mortem adult brains

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