Therapeutic effects of lornoxicam-loaded nanomicellar formula in experimental models of rheumatoid arthritis

Hebatullah Samy Helmy,1 Ayman E El-Sahar,2 Rabab H Sayed,2 Rehab Nabil Shamma,3 Alaa Hamed Salama,4 Eman Maher Elbaz1 1Department of Biochemistry, 2Department of Pharmacology and Toxicology, 3Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, 4Department of...

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Autores principales:	Helmy HS, El-Sahar AE, Sayed RH, Shamma RN, Salama AH, Elbaz EM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	lornoxicam polymeric micelles nano-carriers rheumatoid arthritis inflammatory mediators. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/99d373e34d02436ab33a346885edc585
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spelling	oai:doaj.org-article:99d373e34d02436ab33a346885edc5852021-12-02T02:37:16ZTherapeutic effects of lornoxicam-loaded nanomicellar formula in experimental models of rheumatoid arthritis1178-2013https://doaj.org/article/99d373e34d02436ab33a346885edc5852017-09-01T00:00:00Zhttps://www.dovepress.com/therapeutic-effects--of-lornoxicam-loaded-nanomicellar-formula-in-expe-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Hebatullah Samy Helmy,1 Ayman E El-Sahar,2 Rabab H Sayed,2 Rehab Nabil Shamma,3 Alaa Hamed Salama,4 Eman Maher Elbaz1 1Department of Biochemistry, 2Department of Pharmacology and Toxicology, 3Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, 4Department of Pharmaceutical Technology, National Research Center, Cairo, Egypt Background: Rheumatoid arthritis (RA) is a chronic inflammatory disease treated by nonsteroidal anti-inflammatory drugs (NSAIDs) including lornoxicam (LX). Nanocarriers have been used to increase the efficacy and reduce the side effects of various drugs. The objective of the present study was to compare the therapeutic efficacy of systemic administration of lornoxicam-loaded nanomicellar formula (LX-NM) with that of free LX.Materials and methods: The LX-loaded mixed polymeric nanomicellar formula was prepared by direct equilibrium technique. Two rat models were used in the study: carrageenan-induced acute edema and Freund’s complete adjuvant (FCA)-induced chronic arthritis.Results: The inhibitory effect of LX-NM on carrageenan-induced edema was higher than free LX for the same dose (1.3 mg/kg, i.p.). LX-NM (0.325 mg/kg, i.p.) produced effects comparable to that of diclofenac, which served as a standard. In the FCA model, daily treatment with LX-NM (0.325 mg/kg, i.p.) starting on day 14 significantly reduced the percentage of edema and increased weight growth. However, the same dose of LX failed to confer any significant change. Additionally, LX-NM significantly attenuated the rise of tumor necrosis factor-α (TNF-α), interleukin-1β, prostaglandin E2, nuclear factor-κβ, malondialdehyde and nitric oxide serum levels. In contrast, LX failed to show any significant reduction in elevated serum biomarkers except for TNF-α.Conclusion: LX-NM is an alternative delivery system that is simply prepared at low costs. It showed a superior therapeutic efficacy against RA compared to free LX. Thus, LX-NM can be considered as a promising candidate for treatment of RA and similar inflammatory disorders. Keywords: lornoxicam, polymeric micelles, nano-carriers, rheumatoid arthritis, inflammatory mediatorsHelmy HSEl-Sahar AESayed RHShamma RNSalama AHElbaz EMDove Medical Pressarticlelornoxicampolymeric micellesnano-carriersrheumatoid arthritisinflammatory mediators.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 7015-7023 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	lornoxicam polymeric micelles nano-carriers rheumatoid arthritis inflammatory mediators. Medicine (General) R5-920
spellingShingle	lornoxicam polymeric micelles nano-carriers rheumatoid arthritis inflammatory mediators. Medicine (General) R5-920 Helmy HS El-Sahar AE Sayed RH Shamma RN Salama AH Elbaz EM Therapeutic effects of lornoxicam-loaded nanomicellar formula in experimental models of rheumatoid arthritis
description	Hebatullah Samy Helmy,1 Ayman E El-Sahar,2 Rabab H Sayed,2 Rehab Nabil Shamma,3 Alaa Hamed Salama,4 Eman Maher Elbaz1 1Department of Biochemistry, 2Department of Pharmacology and Toxicology, 3Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, 4Department of Pharmaceutical Technology, National Research Center, Cairo, Egypt Background: Rheumatoid arthritis (RA) is a chronic inflammatory disease treated by nonsteroidal anti-inflammatory drugs (NSAIDs) including lornoxicam (LX). Nanocarriers have been used to increase the efficacy and reduce the side effects of various drugs. The objective of the present study was to compare the therapeutic efficacy of systemic administration of lornoxicam-loaded nanomicellar formula (LX-NM) with that of free LX.Materials and methods: The LX-loaded mixed polymeric nanomicellar formula was prepared by direct equilibrium technique. Two rat models were used in the study: carrageenan-induced acute edema and Freund’s complete adjuvant (FCA)-induced chronic arthritis.Results: The inhibitory effect of LX-NM on carrageenan-induced edema was higher than free LX for the same dose (1.3 mg/kg, i.p.). LX-NM (0.325 mg/kg, i.p.) produced effects comparable to that of diclofenac, which served as a standard. In the FCA model, daily treatment with LX-NM (0.325 mg/kg, i.p.) starting on day 14 significantly reduced the percentage of edema and increased weight growth. However, the same dose of LX failed to confer any significant change. Additionally, LX-NM significantly attenuated the rise of tumor necrosis factor-α (TNF-α), interleukin-1β, prostaglandin E2, nuclear factor-κβ, malondialdehyde and nitric oxide serum levels. In contrast, LX failed to show any significant reduction in elevated serum biomarkers except for TNF-α.Conclusion: LX-NM is an alternative delivery system that is simply prepared at low costs. It showed a superior therapeutic efficacy against RA compared to free LX. Thus, LX-NM can be considered as a promising candidate for treatment of RA and similar inflammatory disorders. Keywords: lornoxicam, polymeric micelles, nano-carriers, rheumatoid arthritis, inflammatory mediators
format	article
author	Helmy HS El-Sahar AE Sayed RH Shamma RN Salama AH Elbaz EM
author_facet	Helmy HS El-Sahar AE Sayed RH Shamma RN Salama AH Elbaz EM
author_sort	Helmy HS
title	Therapeutic effects of lornoxicam-loaded nanomicellar formula in experimental models of rheumatoid arthritis
title_short	Therapeutic effects of lornoxicam-loaded nanomicellar formula in experimental models of rheumatoid arthritis
title_full	Therapeutic effects of lornoxicam-loaded nanomicellar formula in experimental models of rheumatoid arthritis
title_fullStr	Therapeutic effects of lornoxicam-loaded nanomicellar formula in experimental models of rheumatoid arthritis
title_full_unstemmed	Therapeutic effects of lornoxicam-loaded nanomicellar formula in experimental models of rheumatoid arthritis
title_sort	therapeutic effects of lornoxicam-loaded nanomicellar formula in experimental models of rheumatoid arthritis
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/99d373e34d02436ab33a346885edc585
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_version_	1718402306117992448

Therapeutic effects of lornoxicam-loaded nanomicellar formula in experimental models of rheumatoid arthritis

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