Differential expansion of T central memory precursor and effector subsets is regulated by division speed

T cell responses start with antigen-induced rapid cell divisions, and end by division cessation after pathogen clearance. Here, the authors use single-cell fate mapping and nucleoside analogue labelling to show that T central memory precursors proliferate slower than effector subsets and rely on ant...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Lorenz Kretschmer, Michael Flossdorf, Jonas Mir, Yi-Li Cho, Marten Plambeck, Irina Treise, Albulena Toska, Susanne Heinzel, Matthias Schiemann, Dirk H. Busch, Veit R. Buchholz
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Q
Acceso en línea:https://doaj.org/article/99d4f1482d2445208fa58eb282ce25c1
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
Descripción
Sumario:T cell responses start with antigen-induced rapid cell divisions, and end by division cessation after pathogen clearance. Here, the authors use single-cell fate mapping and nucleoside analogue labelling to show that T central memory precursors proliferate slower than effector subsets and rely on antigenic rather than inflammatory stimuli to maintain their cell cycle speed.