Differential expansion of T central memory precursor and effector subsets is regulated by division speed

T cell responses start with antigen-induced rapid cell divisions, and end by division cessation after pathogen clearance. Here, the authors use single-cell fate mapping and nucleoside analogue labelling to show that T central memory precursors proliferate slower than effector subsets and rely on ant...

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Autores principales:	Lorenz Kretschmer, Michael Flossdorf, Jonas Mir, Yi-Li Cho, Marten Plambeck, Irina Treise, Albulena Toska, Susanne Heinzel, Matthias Schiemann, Dirk H. Busch, Veit R. Buchholz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/99d4f1482d2445208fa58eb282ce25c1
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spelling	oai:doaj.org-article:99d4f1482d2445208fa58eb282ce25c12021-12-02T17:31:08ZDifferential expansion of T central memory precursor and effector subsets is regulated by division speed10.1038/s41467-019-13788-w2041-1723https://doaj.org/article/99d4f1482d2445208fa58eb282ce25c12020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13788-whttps://doaj.org/toc/2041-1723T cell responses start with antigen-induced rapid cell divisions, and end by division cessation after pathogen clearance. Here, the authors use single-cell fate mapping and nucleoside analogue labelling to show that T central memory precursors proliferate slower than effector subsets and rely on antigenic rather than inflammatory stimuli to maintain their cell cycle speed.Lorenz KretschmerMichael FlossdorfJonas MirYi-Li ChoMarten PlambeckIrina TreiseAlbulena ToskaSusanne HeinzelMatthias SchiemannDirk H. BuschVeit R. BuchholzNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lorenz Kretschmer Michael Flossdorf Jonas Mir Yi-Li Cho Marten Plambeck Irina Treise Albulena Toska Susanne Heinzel Matthias Schiemann Dirk H. Busch Veit R. Buchholz Differential expansion of T central memory precursor and effector subsets is regulated by division speed
description	T cell responses start with antigen-induced rapid cell divisions, and end by division cessation after pathogen clearance. Here, the authors use single-cell fate mapping and nucleoside analogue labelling to show that T central memory precursors proliferate slower than effector subsets and rely on antigenic rather than inflammatory stimuli to maintain their cell cycle speed.
format	article
author	Lorenz Kretschmer Michael Flossdorf Jonas Mir Yi-Li Cho Marten Plambeck Irina Treise Albulena Toska Susanne Heinzel Matthias Schiemann Dirk H. Busch Veit R. Buchholz
author_facet	Lorenz Kretschmer Michael Flossdorf Jonas Mir Yi-Li Cho Marten Plambeck Irina Treise Albulena Toska Susanne Heinzel Matthias Schiemann Dirk H. Busch Veit R. Buchholz
author_sort	Lorenz Kretschmer
title	Differential expansion of T central memory precursor and effector subsets is regulated by division speed
title_short	Differential expansion of T central memory precursor and effector subsets is regulated by division speed
title_full	Differential expansion of T central memory precursor and effector subsets is regulated by division speed
title_fullStr	Differential expansion of T central memory precursor and effector subsets is regulated by division speed
title_full_unstemmed	Differential expansion of T central memory precursor and effector subsets is regulated by division speed
title_sort	differential expansion of t central memory precursor and effector subsets is regulated by division speed
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/99d4f1482d2445208fa58eb282ce25c1
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Differential expansion of T central memory precursor and effector subsets is regulated by division speed

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