Differential expansion of T central memory precursor and effector subsets is regulated by division speed

T cell responses start with antigen-induced rapid cell divisions, and end by division cessation after pathogen clearance. Here, the authors use single-cell fate mapping and nucleoside analogue labelling to show that T central memory precursors proliferate slower than effector subsets and rely on ant...

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Main Authors: Lorenz Kretschmer, Michael Flossdorf, Jonas Mir, Yi-Li Cho, Marten Plambeck, Irina Treise, Albulena Toska, Susanne Heinzel, Matthias Schiemann, Dirk H. Busch, Veit R. Buchholz
Format: article
Language:EN
Published: Nature Portfolio 2020
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Online Access:https://doaj.org/article/99d4f1482d2445208fa58eb282ce25c1
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