High prevalence of skin disorders among HTLV-1 infected individuals independent of clinical status.

<h4>Background</h4>Human T-cell lymphotropic virus type 1 (HTLV-1) infection can increase the risk of developing skin disorders. This study evaluated the correlation between HTLV-1 proviral load and CD4(+) and CD8(+) T cells count among HTLV-1 infected individuals, with or without skin d...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Renata Okajima, Augusto C P Oliveira, Jerusa Smid, Jorge Casseb, Jose Antonio Sanches
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/99d53eed03cc4d95988df25053c7779b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:99d53eed03cc4d95988df25053c7779b
record_format	dspace
spelling	oai:doaj.org-article:99d53eed03cc4d95988df25053c7779b2021-11-18T09:16:42ZHigh prevalence of skin disorders among HTLV-1 infected individuals independent of clinical status.1935-27271935-273510.1371/journal.pntd.0002546https://doaj.org/article/99d53eed03cc4d95988df25053c7779b2013-11-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24244779/pdf/?tool=EBIhttps://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735<h4>Background</h4>Human T-cell lymphotropic virus type 1 (HTLV-1) infection can increase the risk of developing skin disorders. This study evaluated the correlation between HTLV-1 proviral load and CD4(+) and CD8(+) T cells count among HTLV-1 infected individuals, with or without skin disorders (SD) associated with HTLV-1 infection [SD-HTLV-1: xerosis/ichthyosis, seborrheic dermatitis or infective dermatitis associated to HTLV-1 (IDH)].<h4>Methods</h4>A total of 193 HTLV-1-infected subjects underwent an interview, dermatological examination, initial HTLV-1 proviral load assay, CD4(+) and CD8(+) T cells count, and lymphproliferation assay (LPA).<h4>Results</h4>A total of 147 patients had an abnormal skin condition; 116 (79%) of them also had SD-HTLV-1 and 21% had other dermatological diagnoses. The most prevalent SD-HTLV-1 was xerosis/acquired ichthyosis (48%), followed by seborrheic dermatitis (28%). Patients with SD-HTLV-1 were older (51 vs. 47 years), had a higher prevalence of myelopathy/tropical spastic paraparesis (HAM/TSP) (75%), and had an increased first HTLV-1 proviral load and basal LPA compared with patients without SD-HTLV-1. When excluding HAM/TSP patients, the first HTLV-1 proviral load of SD-HTLV-1 individuals remains higher than no SD-HTLV-1 patients.<h4>Conclusions</h4>There was a high prevalence of skin disorders (76%) among HTLV-1-infected individuals, regardless of clinical status, and 60% of these diseases are considered skin disease associated with HTLV-1 infection.Renata OkajimaAugusto C P OliveiraJerusa SmidJorge CassebJose Antonio SanchesPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 7, Iss 11, p e2546 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
spellingShingle	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Renata Okajima Augusto C P Oliveira Jerusa Smid Jorge Casseb Jose Antonio Sanches High prevalence of skin disorders among HTLV-1 infected individuals independent of clinical status.
description	<h4>Background</h4>Human T-cell lymphotropic virus type 1 (HTLV-1) infection can increase the risk of developing skin disorders. This study evaluated the correlation between HTLV-1 proviral load and CD4(+) and CD8(+) T cells count among HTLV-1 infected individuals, with or without skin disorders (SD) associated with HTLV-1 infection [SD-HTLV-1: xerosis/ichthyosis, seborrheic dermatitis or infective dermatitis associated to HTLV-1 (IDH)].<h4>Methods</h4>A total of 193 HTLV-1-infected subjects underwent an interview, dermatological examination, initial HTLV-1 proviral load assay, CD4(+) and CD8(+) T cells count, and lymphproliferation assay (LPA).<h4>Results</h4>A total of 147 patients had an abnormal skin condition; 116 (79%) of them also had SD-HTLV-1 and 21% had other dermatological diagnoses. The most prevalent SD-HTLV-1 was xerosis/acquired ichthyosis (48%), followed by seborrheic dermatitis (28%). Patients with SD-HTLV-1 were older (51 vs. 47 years), had a higher prevalence of myelopathy/tropical spastic paraparesis (HAM/TSP) (75%), and had an increased first HTLV-1 proviral load and basal LPA compared with patients without SD-HTLV-1. When excluding HAM/TSP patients, the first HTLV-1 proviral load of SD-HTLV-1 individuals remains higher than no SD-HTLV-1 patients.<h4>Conclusions</h4>There was a high prevalence of skin disorders (76%) among HTLV-1-infected individuals, regardless of clinical status, and 60% of these diseases are considered skin disease associated with HTLV-1 infection.
format	article
author	Renata Okajima Augusto C P Oliveira Jerusa Smid Jorge Casseb Jose Antonio Sanches
author_facet	Renata Okajima Augusto C P Oliveira Jerusa Smid Jorge Casseb Jose Antonio Sanches
author_sort	Renata Okajima
title	High prevalence of skin disorders among HTLV-1 infected individuals independent of clinical status.
title_short	High prevalence of skin disorders among HTLV-1 infected individuals independent of clinical status.
title_full	High prevalence of skin disorders among HTLV-1 infected individuals independent of clinical status.
title_fullStr	High prevalence of skin disorders among HTLV-1 infected individuals independent of clinical status.
title_full_unstemmed	High prevalence of skin disorders among HTLV-1 infected individuals independent of clinical status.
title_sort	high prevalence of skin disorders among htlv-1 infected individuals independent of clinical status.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/99d53eed03cc4d95988df25053c7779b
work_keys_str_mv	AT renataokajima highprevalenceofskindisordersamonghtlv1infectedindividualsindependentofclinicalstatus AT augustocpoliveira highprevalenceofskindisordersamonghtlv1infectedindividualsindependentofclinicalstatus AT jerusasmid highprevalenceofskindisordersamonghtlv1infectedindividualsindependentofclinicalstatus AT jorgecasseb highprevalenceofskindisordersamonghtlv1infectedindividualsindependentofclinicalstatus AT joseantoniosanches highprevalenceofskindisordersamonghtlv1infectedindividualsindependentofclinicalstatus
_version_	1718420916509081600

High prevalence of skin disorders among HTLV-1 infected individuals independent of clinical status.

Ejemplares similares