Genetic resistance to rhabdovirus infection in teleost fish is paralleled to the derived cell resistance status.

Genetic factors of resistance and predisposition to viral diseases explain a significant part of the clinical variability observed within host populations. Predisposition to viral diseases has been associated to MHC haplotypes and T cell immunity, but a growing repertoire of innate/intrinsic factors...

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Autores principales:	Eloi R Verrier, Christelle Langevin, Corinne Tohry, Armel Houel, Vincent Ducrocq, Abdenour Benmansour, Edwige Quillet, Pierre Boudinot
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/99d692bce96c4250b5ce361e1a9c3671
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spelling	oai:doaj.org-article:99d692bce96c4250b5ce361e1a9c36712021-11-18T07:22:21ZGenetic resistance to rhabdovirus infection in teleost fish is paralleled to the derived cell resistance status.1932-620310.1371/journal.pone.0033935https://doaj.org/article/99d692bce96c4250b5ce361e1a9c36712012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22514610/?tool=EBIhttps://doaj.org/toc/1932-6203Genetic factors of resistance and predisposition to viral diseases explain a significant part of the clinical variability observed within host populations. Predisposition to viral diseases has been associated to MHC haplotypes and T cell immunity, but a growing repertoire of innate/intrinsic factors are implicated in the genetic determinism of the host susceptibility to viruses. In a long-term study of the genetics of host resistance to fish rhabdoviruses, we produced a collection of double-haploid rainbow trout clones showing a wide range of susceptibility to Viral Hemorrhagic Septicemia Virus (VHSV) waterborne infection. The susceptibility of fibroblastic cell lines derived from these clonal fish was fully consistent with the susceptibility of the parental fish clones. The mechanisms determining the host resistance therefore did not associate with specific host immunity, but rather with innate or intrinsic factors. One cell line was resistant to rhabdovirus infection due to the combination of an early interferon IFN induction--that was not observed in the susceptible cells--and of yet unknown factors that hamper the first steps of the viral cycle. The implication of IFN was well consistent with the wide range of resistance of this genetic background to VSHV and IHNV, to the birnavirus IPNV and the orthomyxovirus ISAV. Another cell line was even more refractory to the VHSV infection through different antiviral mechanisms. This collection of clonal fish and isogenic cell lines provides an interesting model to analyze the relative contribution of antiviral pathways to the resistance to different viruses.Eloi R VerrierChristelle LangevinCorinne TohryArmel HouelVincent DucrocqAbdenour BenmansourEdwige QuilletPierre BoudinotPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 4, p e33935 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Eloi R Verrier Christelle Langevin Corinne Tohry Armel Houel Vincent Ducrocq Abdenour Benmansour Edwige Quillet Pierre Boudinot Genetic resistance to rhabdovirus infection in teleost fish is paralleled to the derived cell resistance status.
description	Genetic factors of resistance and predisposition to viral diseases explain a significant part of the clinical variability observed within host populations. Predisposition to viral diseases has been associated to MHC haplotypes and T cell immunity, but a growing repertoire of innate/intrinsic factors are implicated in the genetic determinism of the host susceptibility to viruses. In a long-term study of the genetics of host resistance to fish rhabdoviruses, we produced a collection of double-haploid rainbow trout clones showing a wide range of susceptibility to Viral Hemorrhagic Septicemia Virus (VHSV) waterborne infection. The susceptibility of fibroblastic cell lines derived from these clonal fish was fully consistent with the susceptibility of the parental fish clones. The mechanisms determining the host resistance therefore did not associate with specific host immunity, but rather with innate or intrinsic factors. One cell line was resistant to rhabdovirus infection due to the combination of an early interferon IFN induction--that was not observed in the susceptible cells--and of yet unknown factors that hamper the first steps of the viral cycle. The implication of IFN was well consistent with the wide range of resistance of this genetic background to VSHV and IHNV, to the birnavirus IPNV and the orthomyxovirus ISAV. Another cell line was even more refractory to the VHSV infection through different antiviral mechanisms. This collection of clonal fish and isogenic cell lines provides an interesting model to analyze the relative contribution of antiviral pathways to the resistance to different viruses.
format	article
author	Eloi R Verrier Christelle Langevin Corinne Tohry Armel Houel Vincent Ducrocq Abdenour Benmansour Edwige Quillet Pierre Boudinot
author_facet	Eloi R Verrier Christelle Langevin Corinne Tohry Armel Houel Vincent Ducrocq Abdenour Benmansour Edwige Quillet Pierre Boudinot
author_sort	Eloi R Verrier
title	Genetic resistance to rhabdovirus infection in teleost fish is paralleled to the derived cell resistance status.
title_short	Genetic resistance to rhabdovirus infection in teleost fish is paralleled to the derived cell resistance status.
title_full	Genetic resistance to rhabdovirus infection in teleost fish is paralleled to the derived cell resistance status.
title_fullStr	Genetic resistance to rhabdovirus infection in teleost fish is paralleled to the derived cell resistance status.
title_full_unstemmed	Genetic resistance to rhabdovirus infection in teleost fish is paralleled to the derived cell resistance status.
title_sort	genetic resistance to rhabdovirus infection in teleost fish is paralleled to the derived cell resistance status.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/99d692bce96c4250b5ce361e1a9c3671
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Genetic resistance to rhabdovirus infection in teleost fish is paralleled to the derived cell resistance status.

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