Relation between Arterial Stiffness and Markers of Inflammation and Hemostasis – Data from the Population-based Gutenberg Health Study

Abstract The relation between inflammation, hemostasis and arterial stiffness is of pathophysiological relevance for the development of cardiovascular disease (CVD). Data investigating this interplay using stiffness index (SI) by digital photoplethysmography are not available yet. Therefore, sex-spe...

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Autores principales:	Natalie Arnold, Tommaso Gori, Renate B. Schnabel, Andreas Schulz, Jürgen H. Prochaska, Tanja Zeller, Harald Binder, Norbert Pfeiffer, Manfred Beutel, Christine Espinola-Klein, Karl J. Lackner, Stefan Blankenberg, Thomas Münzel, Philipp S. Wild
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/99d85646bcea4e6da9c3b907bcc026de
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spelling	oai:doaj.org-article:99d85646bcea4e6da9c3b907bcc026de2021-12-02T12:32:16ZRelation between Arterial Stiffness and Markers of Inflammation and Hemostasis – Data from the Population-based Gutenberg Health Study10.1038/s41598-017-06175-22045-2322https://doaj.org/article/99d85646bcea4e6da9c3b907bcc026de2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06175-2https://doaj.org/toc/2045-2322Abstract The relation between inflammation, hemostasis and arterial stiffness is of pathophysiological relevance for the development of cardiovascular disease (CVD). Data investigating this interplay using stiffness index (SI) by digital photoplethysmography are not available yet. Therefore, sex-specific relation between SI and inflammatory and hemostatic biomarkers was investigated within 13,724 subjects from the population-based Gutenberg Health Study. C-reactive protein (CRP), white blood cell count (WBCC), neopterin, interleukin-18, interleukin-1 receptor antagonist (IL-1RA), fibrinogen and hematocrit were measured. Multivariable linear regression analysis with adjustment for cardiovascular risk factors, medication, and hormonal status (in females) revealed an independent association between SI and WBCC, IL-1RA and hematocrit in both sexes, and with fibrinogen in women. There was a joint effect of increasing tertiles of SI and biomarker concentrations for future CVD risk prediction. Subjects with both SI and biomarker concentration above the median had the worst overall survival and with both below the median the best survival during a follow-up period of 6.2 ± 1.7 years, except for hematocrit. The results support the relation between inflammation, hemostasis and arterial stiffness measured by digital photoplethysmography. Markers of inflammation and hemostasis modulate the ability of SI to identify subjects at risk for future CVD or higher mortality.Natalie ArnoldTommaso GoriRenate B. SchnabelAndreas SchulzJürgen H. ProchaskaTanja ZellerHarald BinderNorbert PfeifferManfred BeutelChristine Espinola-KleinKarl J. LacknerStefan BlankenbergThomas MünzelPhilipp S. WildNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Natalie Arnold Tommaso Gori Renate B. Schnabel Andreas Schulz Jürgen H. Prochaska Tanja Zeller Harald Binder Norbert Pfeiffer Manfred Beutel Christine Espinola-Klein Karl J. Lackner Stefan Blankenberg Thomas Münzel Philipp S. Wild Relation between Arterial Stiffness and Markers of Inflammation and Hemostasis – Data from the Population-based Gutenberg Health Study
description	Abstract The relation between inflammation, hemostasis and arterial stiffness is of pathophysiological relevance for the development of cardiovascular disease (CVD). Data investigating this interplay using stiffness index (SI) by digital photoplethysmography are not available yet. Therefore, sex-specific relation between SI and inflammatory and hemostatic biomarkers was investigated within 13,724 subjects from the population-based Gutenberg Health Study. C-reactive protein (CRP), white blood cell count (WBCC), neopterin, interleukin-18, interleukin-1 receptor antagonist (IL-1RA), fibrinogen and hematocrit were measured. Multivariable linear regression analysis with adjustment for cardiovascular risk factors, medication, and hormonal status (in females) revealed an independent association between SI and WBCC, IL-1RA and hematocrit in both sexes, and with fibrinogen in women. There was a joint effect of increasing tertiles of SI and biomarker concentrations for future CVD risk prediction. Subjects with both SI and biomarker concentration above the median had the worst overall survival and with both below the median the best survival during a follow-up period of 6.2 ± 1.7 years, except for hematocrit. The results support the relation between inflammation, hemostasis and arterial stiffness measured by digital photoplethysmography. Markers of inflammation and hemostasis modulate the ability of SI to identify subjects at risk for future CVD or higher mortality.
format	article
author	Natalie Arnold Tommaso Gori Renate B. Schnabel Andreas Schulz Jürgen H. Prochaska Tanja Zeller Harald Binder Norbert Pfeiffer Manfred Beutel Christine Espinola-Klein Karl J. Lackner Stefan Blankenberg Thomas Münzel Philipp S. Wild
author_facet	Natalie Arnold Tommaso Gori Renate B. Schnabel Andreas Schulz Jürgen H. Prochaska Tanja Zeller Harald Binder Norbert Pfeiffer Manfred Beutel Christine Espinola-Klein Karl J. Lackner Stefan Blankenberg Thomas Münzel Philipp S. Wild
author_sort	Natalie Arnold
title	Relation between Arterial Stiffness and Markers of Inflammation and Hemostasis – Data from the Population-based Gutenberg Health Study
title_short	Relation between Arterial Stiffness and Markers of Inflammation and Hemostasis – Data from the Population-based Gutenberg Health Study
title_full	Relation between Arterial Stiffness and Markers of Inflammation and Hemostasis – Data from the Population-based Gutenberg Health Study
title_fullStr	Relation between Arterial Stiffness and Markers of Inflammation and Hemostasis – Data from the Population-based Gutenberg Health Study
title_full_unstemmed	Relation between Arterial Stiffness and Markers of Inflammation and Hemostasis – Data from the Population-based Gutenberg Health Study
title_sort	relation between arterial stiffness and markers of inflammation and hemostasis – data from the population-based gutenberg health study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/99d85646bcea4e6da9c3b907bcc026de
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Relation between Arterial Stiffness and Markers of Inflammation and Hemostasis – Data from the Population-based Gutenberg Health Study

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