Transferrin as a thermosensitizer in radiofrequency hyperthermia for cancer treatment

Abstract One of the main characteristics of cancer tissues is poor development of neovascularization that results in a limited blood circulation. Because of this phenomenon, it is harder for cancer tissues to diffuse their elevated heat into other parts of the body. The scientific principle of radio...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hea-Jong Chung, Heui-Kwan Lee, Ki Beom Kwon, Hyeon-Jin Kim, Seong-Tshool Hong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/99d9e8ee77f04c18bb8c57a03e163d61
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:99d9e8ee77f04c18bb8c57a03e163d61
record_format	dspace
spelling	oai:doaj.org-article:99d9e8ee77f04c18bb8c57a03e163d612021-12-02T15:07:57ZTransferrin as a thermosensitizer in radiofrequency hyperthermia for cancer treatment10.1038/s41598-018-31232-92045-2322https://doaj.org/article/99d9e8ee77f04c18bb8c57a03e163d612018-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-31232-9https://doaj.org/toc/2045-2322Abstract One of the main characteristics of cancer tissues is poor development of neovascularization that results in a limited blood circulation. Because of this phenomenon, it is harder for cancer tissues to diffuse their elevated heat into other parts of the body. The scientific principle of radiofrequency hyperthermia relies on this quality of cancer tissues which with higher temperature becomes more apparent. Despite the obvious necessity to selectively heat the cancer tissue for radiofrequency hyperthermia, a proper thermosensitizer has not been developed until now. Here, we show that transferrin containing ferric ion could be an ideal thermosensitizer for the increased efficiency of radiofrequency hyperthermia. In our result, the ferric ion-enriched cancer tissues dramatically react with 13.56 MHz radiofrequency wave to cause cancer-selective dielectric temperature increment. The overall anticancer efficacy of a 13.56 MHz radiofrequency hyperthermia using transferrin as a thermosensitizer was much higher than the oncotherapeutic efficacy of paclitaxel, successfully eradicating cancer in a tumor-xenografted mouse experiment.Hea-Jong ChungHeui-Kwan LeeKi Beom KwonHyeon-Jin KimSeong-Tshool HongNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hea-Jong Chung Heui-Kwan Lee Ki Beom Kwon Hyeon-Jin Kim Seong-Tshool Hong Transferrin as a thermosensitizer in radiofrequency hyperthermia for cancer treatment
description	Abstract One of the main characteristics of cancer tissues is poor development of neovascularization that results in a limited blood circulation. Because of this phenomenon, it is harder for cancer tissues to diffuse their elevated heat into other parts of the body. The scientific principle of radiofrequency hyperthermia relies on this quality of cancer tissues which with higher temperature becomes more apparent. Despite the obvious necessity to selectively heat the cancer tissue for radiofrequency hyperthermia, a proper thermosensitizer has not been developed until now. Here, we show that transferrin containing ferric ion could be an ideal thermosensitizer for the increased efficiency of radiofrequency hyperthermia. In our result, the ferric ion-enriched cancer tissues dramatically react with 13.56 MHz radiofrequency wave to cause cancer-selective dielectric temperature increment. The overall anticancer efficacy of a 13.56 MHz radiofrequency hyperthermia using transferrin as a thermosensitizer was much higher than the oncotherapeutic efficacy of paclitaxel, successfully eradicating cancer in a tumor-xenografted mouse experiment.
format	article
author	Hea-Jong Chung Heui-Kwan Lee Ki Beom Kwon Hyeon-Jin Kim Seong-Tshool Hong
author_facet	Hea-Jong Chung Heui-Kwan Lee Ki Beom Kwon Hyeon-Jin Kim Seong-Tshool Hong
author_sort	Hea-Jong Chung
title	Transferrin as a thermosensitizer in radiofrequency hyperthermia for cancer treatment
title_short	Transferrin as a thermosensitizer in radiofrequency hyperthermia for cancer treatment
title_full	Transferrin as a thermosensitizer in radiofrequency hyperthermia for cancer treatment
title_fullStr	Transferrin as a thermosensitizer in radiofrequency hyperthermia for cancer treatment
title_full_unstemmed	Transferrin as a thermosensitizer in radiofrequency hyperthermia for cancer treatment
title_sort	transferrin as a thermosensitizer in radiofrequency hyperthermia for cancer treatment
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/99d9e8ee77f04c18bb8c57a03e163d61
work_keys_str_mv	AT heajongchung transferrinasathermosensitizerinradiofrequencyhyperthermiaforcancertreatment AT heuikwanlee transferrinasathermosensitizerinradiofrequencyhyperthermiaforcancertreatment AT kibeomkwon transferrinasathermosensitizerinradiofrequencyhyperthermiaforcancertreatment AT hyeonjinkim transferrinasathermosensitizerinradiofrequencyhyperthermiaforcancertreatment AT seongtshoolhong transferrinasathermosensitizerinradiofrequencyhyperthermiaforcancertreatment
_version_	1718388333794557952

Transferrin as a thermosensitizer in radiofrequency hyperthermia for cancer treatment

Ejemplares similares