Apolipoprotein-b gen and its role in formation of essential hypertension

For two groups of Russian teenagers the proportion of deletion (Del) allele of the apolipoprotein-B gene polymorphism (ApoB, Ins/Del, rs17240441) was studied. One group of 70 teenagers with essential hypertension, and the comparison group - 73 healthy teenagers. In both groups, the most common genot...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	L. I. Kolesnikova, O. V. Kalyuzhnaya, L. V. Rychkova, A. S. Kosovtseva, O. A. Yershova, T. V. Mandzyak, T. A. Bairova
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2015
Materias:	apolipoprotein-b genotype the russians lipids teenagers Science Q
Acceso en línea:	https://doaj.org/article/99da43d082184fc2b97ceb4a86462efb
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:99da43d082184fc2b97ceb4a86462efb
record_format	dspace
spelling	oai:doaj.org-article:99da43d082184fc2b97ceb4a86462efb2021-11-23T06:14:33ZApolipoprotein-b gen and its role in formation of essential hypertension2541-94202587-9596https://doaj.org/article/99da43d082184fc2b97ceb4a86462efb2015-11-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/140https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596For two groups of Russian teenagers the proportion of deletion (Del) allele of the apolipoprotein-B gene polymorphism (ApoB, Ins/Del, rs17240441) was studied. One group of 70 teenagers with essential hypertension, and the comparison group - 73 healthy teenagers. In both groups, the most common genotype was heterozygous genotype Ins/Del, in the group with essential hypertension it was 67,1 %, in the control group - 52,1 %. The frequency of Del allele in the group with essential hypertension was 47,9 %, which was significantly higher than in the comparison group - 30,1 % (p = 0,003). Thus, the high frequency of deletion allele in the studied group with hypertension indicates an increased risk of cardiovascular disease in this group in the future and has prognostic significance.L. I. KolesnikovaO. V. KalyuzhnayaL. V. RychkovaA. S. KosovtsevaO. A. YershovaT. V. MandzyakT. A. BairovaScientific Сentre for Family Health and Human Reproduction Problemsarticleapolipoprotein-bgenotypethe russianslipidsteenagersScienceQRUActa Biomedica Scientifica, Vol 0, Iss 6, Pp 58-61 (2015)
institution	DOAJ
collection	DOAJ
language	RU
topic	apolipoprotein-b genotype the russians lipids teenagers Science Q
spellingShingle	apolipoprotein-b genotype the russians lipids teenagers Science Q L. I. Kolesnikova O. V. Kalyuzhnaya L. V. Rychkova A. S. Kosovtseva O. A. Yershova T. V. Mandzyak T. A. Bairova Apolipoprotein-b gen and its role in formation of essential hypertension
description	For two groups of Russian teenagers the proportion of deletion (Del) allele of the apolipoprotein-B gene polymorphism (ApoB, Ins/Del, rs17240441) was studied. One group of 70 teenagers with essential hypertension, and the comparison group - 73 healthy teenagers. In both groups, the most common genotype was heterozygous genotype Ins/Del, in the group with essential hypertension it was 67,1 %, in the control group - 52,1 %. The frequency of Del allele in the group with essential hypertension was 47,9 %, which was significantly higher than in the comparison group - 30,1 % (p = 0,003). Thus, the high frequency of deletion allele in the studied group with hypertension indicates an increased risk of cardiovascular disease in this group in the future and has prognostic significance.
format	article
author	L. I. Kolesnikova O. V. Kalyuzhnaya L. V. Rychkova A. S. Kosovtseva O. A. Yershova T. V. Mandzyak T. A. Bairova
author_facet	L. I. Kolesnikova O. V. Kalyuzhnaya L. V. Rychkova A. S. Kosovtseva O. A. Yershova T. V. Mandzyak T. A. Bairova
author_sort	L. I. Kolesnikova
title	Apolipoprotein-b gen and its role in formation of essential hypertension
title_short	Apolipoprotein-b gen and its role in formation of essential hypertension
title_full	Apolipoprotein-b gen and its role in formation of essential hypertension
title_fullStr	Apolipoprotein-b gen and its role in formation of essential hypertension
title_full_unstemmed	Apolipoprotein-b gen and its role in formation of essential hypertension
title_sort	apolipoprotein-b gen and its role in formation of essential hypertension
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2015
url	https://doaj.org/article/99da43d082184fc2b97ceb4a86462efb
work_keys_str_mv	AT likolesnikova apolipoproteinbgenanditsroleinformationofessentialhypertension AT ovkalyuzhnaya apolipoproteinbgenanditsroleinformationofessentialhypertension AT lvrychkova apolipoproteinbgenanditsroleinformationofessentialhypertension AT askosovtseva apolipoproteinbgenanditsroleinformationofessentialhypertension AT oayershova apolipoproteinbgenanditsroleinformationofessentialhypertension AT tvmandzyak apolipoproteinbgenanditsroleinformationofessentialhypertension AT tabairova apolipoproteinbgenanditsroleinformationofessentialhypertension
_version_	1718417085061660672

Apolipoprotein-b gen and its role in formation of essential hypertension

Ejemplares similares