Comparison of C‐reactive protein concentrations in dogs with Bordetella bronchiseptica infection and aspiration bronchopneumonia

Abstract Background C‐reactive protein (CRP) is a well‐known acute‐phase protein in dogs that may discriminate bacterial bronchopneumonia from other pulmonary conditions. Bronchopneumonia caused by Bordetella bronchiseptica (Bb) is common but the associated increase in CRP concentration in naturally...

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Autores principales:	Aude Morgane Canonne, Maud Menard, Christelle Maurey, Ghita Benchrekroun, Nina Fernandes Rodrigues, Frédéric Billen, Cecile Clercx
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	aspiration pneumonia CRP parenchymal disease pneumonia respiratory tract Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/99df847552eb4b5d90244f508b76b777
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spelling	oai:doaj.org-article:99df847552eb4b5d90244f508b76b7772021-11-30T17:01:04ZComparison of C‐reactive protein concentrations in dogs with Bordetella bronchiseptica infection and aspiration bronchopneumonia1939-16760891-664010.1111/jvim.16091https://doaj.org/article/99df847552eb4b5d90244f508b76b7772021-05-01T00:00:00Zhttps://doi.org/10.1111/jvim.16091https://doaj.org/toc/0891-6640https://doaj.org/toc/1939-1676Abstract Background C‐reactive protein (CRP) is a well‐known acute‐phase protein in dogs that may discriminate bacterial bronchopneumonia from other pulmonary conditions. Bronchopneumonia caused by Bordetella bronchiseptica (Bb) is common but the associated increase in CRP concentration in naturally infected dogs has not been fully explored. Objective To compare CRP concentrations of dogs with Bb infection, with or without radiographic pulmonary lesions, to dogs with aspiration bronchopneumonia (ABP). Animals Sixteen dogs with Bb infection and 36 dogs with ABP. Methods Retrospective study. C‐reactive protein concentrations and thoracic radiographs were available for each dog. Results Eleven dogs with Bb infection had alveolar lesions. In all dogs, CRP concentration was mildly increased (14‐38 mg/L). In the 5 dogs without alveolar lesions, CRP concentration was within the reference range in all but 1 dog, in which it was slightly increased. Median CRP concentration was significantly higher in dogs with alveolar lesions (20 mg/L) compared with dogs without alveolar lesions (5 mg/L; p < .002). In dogs with Bb infection, median duration of clinical signs was not different between dogs with normal CRP concentration and dogs with increased concentration. In dogs with Bb infection either with or without alveolar lessions, median CRP concentration was significantly lower (20 mg/L) than in dogs with ABP (118 mg/L; p < .001). Conclusions and Clinical Importance In contrast to dogs with APB, CRP was not a good marker for the diagnosis of dogs suspected to have bordetellosis. Confirmation of Bb infection still requires lower airway sampling.Aude Morgane CanonneMaud MenardChristelle MaureyGhita BenchrekrounNina Fernandes RodriguesFrédéric BillenCecile ClercxWileyarticleaspiration pneumoniaCRPparenchymal diseasepneumoniarespiratory tractVeterinary medicineSF600-1100ENJournal of Veterinary Internal Medicine, Vol 35, Iss 3, Pp 1519-1524 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	aspiration pneumonia CRP parenchymal disease pneumonia respiratory tract Veterinary medicine SF600-1100
spellingShingle	aspiration pneumonia CRP parenchymal disease pneumonia respiratory tract Veterinary medicine SF600-1100 Aude Morgane Canonne Maud Menard Christelle Maurey Ghita Benchrekroun Nina Fernandes Rodrigues Frédéric Billen Cecile Clercx Comparison of C‐reactive protein concentrations in dogs with Bordetella bronchiseptica infection and aspiration bronchopneumonia
description	Abstract Background C‐reactive protein (CRP) is a well‐known acute‐phase protein in dogs that may discriminate bacterial bronchopneumonia from other pulmonary conditions. Bronchopneumonia caused by Bordetella bronchiseptica (Bb) is common but the associated increase in CRP concentration in naturally infected dogs has not been fully explored. Objective To compare CRP concentrations of dogs with Bb infection, with or without radiographic pulmonary lesions, to dogs with aspiration bronchopneumonia (ABP). Animals Sixteen dogs with Bb infection and 36 dogs with ABP. Methods Retrospective study. C‐reactive protein concentrations and thoracic radiographs were available for each dog. Results Eleven dogs with Bb infection had alveolar lesions. In all dogs, CRP concentration was mildly increased (14‐38 mg/L). In the 5 dogs without alveolar lesions, CRP concentration was within the reference range in all but 1 dog, in which it was slightly increased. Median CRP concentration was significantly higher in dogs with alveolar lesions (20 mg/L) compared with dogs without alveolar lesions (5 mg/L; p < .002). In dogs with Bb infection, median duration of clinical signs was not different between dogs with normal CRP concentration and dogs with increased concentration. In dogs with Bb infection either with or without alveolar lessions, median CRP concentration was significantly lower (20 mg/L) than in dogs with ABP (118 mg/L; p < .001). Conclusions and Clinical Importance In contrast to dogs with APB, CRP was not a good marker for the diagnosis of dogs suspected to have bordetellosis. Confirmation of Bb infection still requires lower airway sampling.
format	article
author	Aude Morgane Canonne Maud Menard Christelle Maurey Ghita Benchrekroun Nina Fernandes Rodrigues Frédéric Billen Cecile Clercx
author_facet	Aude Morgane Canonne Maud Menard Christelle Maurey Ghita Benchrekroun Nina Fernandes Rodrigues Frédéric Billen Cecile Clercx
author_sort	Aude Morgane Canonne
title	Comparison of C‐reactive protein concentrations in dogs with Bordetella bronchiseptica infection and aspiration bronchopneumonia
title_short	Comparison of C‐reactive protein concentrations in dogs with Bordetella bronchiseptica infection and aspiration bronchopneumonia
title_full	Comparison of C‐reactive protein concentrations in dogs with Bordetella bronchiseptica infection and aspiration bronchopneumonia
title_fullStr	Comparison of C‐reactive protein concentrations in dogs with Bordetella bronchiseptica infection and aspiration bronchopneumonia
title_full_unstemmed	Comparison of C‐reactive protein concentrations in dogs with Bordetella bronchiseptica infection and aspiration bronchopneumonia
title_sort	comparison of c‐reactive protein concentrations in dogs with bordetella bronchiseptica infection and aspiration bronchopneumonia
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/99df847552eb4b5d90244f508b76b777
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Comparison of C‐reactive protein concentrations in dogs with Bordetella bronchiseptica infection and aspiration bronchopneumonia

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