Polymorphic variants in Sweet and Umami taste receptor genes and birthweight

Abstract The first thousand days of life from conception have a significant impact on the health status with short, and long-term effects. Among several anthropometric and maternal lifestyle parameters birth weight plays a crucial role on the growth and neurological development of infants. Recent ge...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Riccardo Farinella, Ilaria Erbi, Alice Bedini, Sara Donato, Manuel Gentiluomo, Claudia Angelucci, Antonella Lupetti, Armando Cuttano, Francesca Moscuzza, Cristina Tuoni, Cosmeri Rizzato, Massimiliano Ciantelli, Daniele Campa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/99e35d5bab1047039d36f9f1cd05b4b9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:99e35d5bab1047039d36f9f1cd05b4b9
record_format	dspace
spelling	oai:doaj.org-article:99e35d5bab1047039d36f9f1cd05b4b92021-12-02T13:20:20ZPolymorphic variants in Sweet and Umami taste receptor genes and birthweight10.1038/s41598-021-84491-42045-2322https://doaj.org/article/99e35d5bab1047039d36f9f1cd05b4b92021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84491-4https://doaj.org/toc/2045-2322Abstract The first thousand days of life from conception have a significant impact on the health status with short, and long-term effects. Among several anthropometric and maternal lifestyle parameters birth weight plays a crucial role on the growth and neurological development of infants. Recent genome wide association studies (GWAS) have demonstrated a robust foetal and maternal genetic background of birth weight, however only a small proportion of the genetic hereditability has been already identified. Considering the extensive number of phenotypes on which they are involved, we focused on identifying the possible effect of genetic variants belonging to taste receptor genes and birthweight. In the human genome there are two taste receptors family the bitter receptors (TAS2Rs) and the sweet and umami receptors (TAS1Rs). In particular sweet perception is due to a heterodimeric receptor encoded by the TAS1R2 and the TAS1R3 gene, while the umami taste receptor is encoded by the TAS1R1 and the TAS1R3 genes. We observed that carriers of the T allele of the TAS1R1-rs4908932 SNPs showed an increase in birthweight compared to GG homozygotes Coeff: 87.40 (35.13–139.68) p-value = 0.001. The association remained significant after correction for multiple testing. TAS1R1-rs4908932 is a potentially functional SNP and is in linkage disequilibrium with another polymorphism that has been associated with BMI in adults showing the importance of this variant from the early stages of conception through all the adult life.Riccardo FarinellaIlaria ErbiAlice BediniSara DonatoManuel GentiluomoClaudia AngelucciAntonella LupettiArmando CuttanoFrancesca MoscuzzaCristina TuoniCosmeri RizzatoMassimiliano CiantelliDaniele CampaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Riccardo Farinella Ilaria Erbi Alice Bedini Sara Donato Manuel Gentiluomo Claudia Angelucci Antonella Lupetti Armando Cuttano Francesca Moscuzza Cristina Tuoni Cosmeri Rizzato Massimiliano Ciantelli Daniele Campa Polymorphic variants in Sweet and Umami taste receptor genes and birthweight
description	Abstract The first thousand days of life from conception have a significant impact on the health status with short, and long-term effects. Among several anthropometric and maternal lifestyle parameters birth weight plays a crucial role on the growth and neurological development of infants. Recent genome wide association studies (GWAS) have demonstrated a robust foetal and maternal genetic background of birth weight, however only a small proportion of the genetic hereditability has been already identified. Considering the extensive number of phenotypes on which they are involved, we focused on identifying the possible effect of genetic variants belonging to taste receptor genes and birthweight. In the human genome there are two taste receptors family the bitter receptors (TAS2Rs) and the sweet and umami receptors (TAS1Rs). In particular sweet perception is due to a heterodimeric receptor encoded by the TAS1R2 and the TAS1R3 gene, while the umami taste receptor is encoded by the TAS1R1 and the TAS1R3 genes. We observed that carriers of the T allele of the TAS1R1-rs4908932 SNPs showed an increase in birthweight compared to GG homozygotes Coeff: 87.40 (35.13–139.68) p-value = 0.001. The association remained significant after correction for multiple testing. TAS1R1-rs4908932 is a potentially functional SNP and is in linkage disequilibrium with another polymorphism that has been associated with BMI in adults showing the importance of this variant from the early stages of conception through all the adult life.
format	article
author	Riccardo Farinella Ilaria Erbi Alice Bedini Sara Donato Manuel Gentiluomo Claudia Angelucci Antonella Lupetti Armando Cuttano Francesca Moscuzza Cristina Tuoni Cosmeri Rizzato Massimiliano Ciantelli Daniele Campa
author_facet	Riccardo Farinella Ilaria Erbi Alice Bedini Sara Donato Manuel Gentiluomo Claudia Angelucci Antonella Lupetti Armando Cuttano Francesca Moscuzza Cristina Tuoni Cosmeri Rizzato Massimiliano Ciantelli Daniele Campa
author_sort	Riccardo Farinella
title	Polymorphic variants in Sweet and Umami taste receptor genes and birthweight
title_short	Polymorphic variants in Sweet and Umami taste receptor genes and birthweight
title_full	Polymorphic variants in Sweet and Umami taste receptor genes and birthweight
title_fullStr	Polymorphic variants in Sweet and Umami taste receptor genes and birthweight
title_full_unstemmed	Polymorphic variants in Sweet and Umami taste receptor genes and birthweight
title_sort	polymorphic variants in sweet and umami taste receptor genes and birthweight
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/99e35d5bab1047039d36f9f1cd05b4b9
work_keys_str_mv	AT riccardofarinella polymorphicvariantsinsweetandumamitastereceptorgenesandbirthweight AT ilariaerbi polymorphicvariantsinsweetandumamitastereceptorgenesandbirthweight AT alicebedini polymorphicvariantsinsweetandumamitastereceptorgenesandbirthweight AT saradonato polymorphicvariantsinsweetandumamitastereceptorgenesandbirthweight AT manuelgentiluomo polymorphicvariantsinsweetandumamitastereceptorgenesandbirthweight AT claudiaangelucci polymorphicvariantsinsweetandumamitastereceptorgenesandbirthweight AT antonellalupetti polymorphicvariantsinsweetandumamitastereceptorgenesandbirthweight AT armandocuttano polymorphicvariantsinsweetandumamitastereceptorgenesandbirthweight AT francescamoscuzza polymorphicvariantsinsweetandumamitastereceptorgenesandbirthweight AT cristinatuoni polymorphicvariantsinsweetandumamitastereceptorgenesandbirthweight AT cosmeririzzato polymorphicvariantsinsweetandumamitastereceptorgenesandbirthweight AT massimilianociantelli polymorphicvariantsinsweetandumamitastereceptorgenesandbirthweight AT danielecampa polymorphicvariantsinsweetandumamitastereceptorgenesandbirthweight
_version_	1718393226766843904

Polymorphic variants in Sweet and Umami taste receptor genes and birthweight

Ejemplares similares