Alcohol consumption and the risk of gastric intestinal metaplasia in a U.S. Veterans population

<h4>Background</h4> Chronic alcohol use is a risk factor for non-cardia gastric adenocarcinoma. However, it is less well understood whether alcohol use is a risk factor for premalignant mucosal changes, namely gastric intestinal metaplasia. We examined the association between various par...

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Autores principales:	Hudson M. Holmes, Andre G. Jove, Mimi C. Tan, Hashem B. El-Serag, Aaron P. Thrift
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/99e88876ecd94cf2bd60ea1cbada36a8
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spelling	oai:doaj.org-article:99e88876ecd94cf2bd60ea1cbada36a82021-11-25T05:54:24ZAlcohol consumption and the risk of gastric intestinal metaplasia in a U.S. Veterans population1932-6203https://doaj.org/article/99e88876ecd94cf2bd60ea1cbada36a82021-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8592489/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4> Chronic alcohol use is a risk factor for non-cardia gastric adenocarcinoma. However, it is less well understood whether alcohol use is a risk factor for premalignant mucosal changes, namely gastric intestinal metaplasia. We examined the association between various parameters of alcohol use and risk of gastric intestinal metaplasia. <h4>Methods</h4> We used data from 2084 participants (including 403 with gastric intestinal metaplasia) recruited between February 2008-August 2013 into a cross-sectional study at the Michael E. DeBakey Veterans Affairs Medical Center in Houston, Texas. All participants underwent a study upper endoscopy with systematic gastric mapping biopsies. Cases had intestinal metaplasia on any non-cardia gastric biopsy. Participants self-reported lifetime history of alcohol consumption, along with other lifestyle risk factors, through a study survey. We calculated odds ratios (OR) and 95% confidence intervals (95% CI) for categories of average alcohol consumption using multivariable logistic regression, and restricted cubic spline regression to explore the potential shape of a dose-response relationship. <h4>Results</h4> Compared to lifelong non-drinkers, individuals who consumed on average ≥28 drinks per week had no elevated risk for gastric intestinal metaplasia (adjusted OR, 1.27; 95% CI, 0.74–2.19). Based on a spline regression curve and its 95% CI, there was also no demonstrable association between cumulative lifetime alcohol consumption and risk of gastric intestinal metaplasia. Similarly, we found no association between beverage type (beer, wine, liquor/spirits) and risk for gastric intestinal metaplasia. <h4>Conclusions</h4> Neither amount of alcohol consumed nor specific beverage type was associated with risk of gastric intestinal metaplasia.Hudson M. HolmesAndre G. JoveMimi C. TanHashem B. El-SeragAaron P. ThriftPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hudson M. Holmes Andre G. Jove Mimi C. Tan Hashem B. El-Serag Aaron P. Thrift Alcohol consumption and the risk of gastric intestinal metaplasia in a U.S. Veterans population
description	<h4>Background</h4> Chronic alcohol use is a risk factor for non-cardia gastric adenocarcinoma. However, it is less well understood whether alcohol use is a risk factor for premalignant mucosal changes, namely gastric intestinal metaplasia. We examined the association between various parameters of alcohol use and risk of gastric intestinal metaplasia. <h4>Methods</h4> We used data from 2084 participants (including 403 with gastric intestinal metaplasia) recruited between February 2008-August 2013 into a cross-sectional study at the Michael E. DeBakey Veterans Affairs Medical Center in Houston, Texas. All participants underwent a study upper endoscopy with systematic gastric mapping biopsies. Cases had intestinal metaplasia on any non-cardia gastric biopsy. Participants self-reported lifetime history of alcohol consumption, along with other lifestyle risk factors, through a study survey. We calculated odds ratios (OR) and 95% confidence intervals (95% CI) for categories of average alcohol consumption using multivariable logistic regression, and restricted cubic spline regression to explore the potential shape of a dose-response relationship. <h4>Results</h4> Compared to lifelong non-drinkers, individuals who consumed on average ≥28 drinks per week had no elevated risk for gastric intestinal metaplasia (adjusted OR, 1.27; 95% CI, 0.74–2.19). Based on a spline regression curve and its 95% CI, there was also no demonstrable association between cumulative lifetime alcohol consumption and risk of gastric intestinal metaplasia. Similarly, we found no association between beverage type (beer, wine, liquor/spirits) and risk for gastric intestinal metaplasia. <h4>Conclusions</h4> Neither amount of alcohol consumed nor specific beverage type was associated with risk of gastric intestinal metaplasia.
format	article
author	Hudson M. Holmes Andre G. Jove Mimi C. Tan Hashem B. El-Serag Aaron P. Thrift
author_facet	Hudson M. Holmes Andre G. Jove Mimi C. Tan Hashem B. El-Serag Aaron P. Thrift
author_sort	Hudson M. Holmes
title	Alcohol consumption and the risk of gastric intestinal metaplasia in a U.S. Veterans population
title_short	Alcohol consumption and the risk of gastric intestinal metaplasia in a U.S. Veterans population
title_full	Alcohol consumption and the risk of gastric intestinal metaplasia in a U.S. Veterans population
title_fullStr	Alcohol consumption and the risk of gastric intestinal metaplasia in a U.S. Veterans population
title_full_unstemmed	Alcohol consumption and the risk of gastric intestinal metaplasia in a U.S. Veterans population
title_sort	alcohol consumption and the risk of gastric intestinal metaplasia in a u.s. veterans population
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/99e88876ecd94cf2bd60ea1cbada36a8
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Alcohol consumption and the risk of gastric intestinal metaplasia in a U.S. Veterans population

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