Inhibition of Y1 receptor signaling improves islet transplant outcome

Islet transplantation is considered one of the potential treatments for T1DM but limited islet survival and their impaired function pose limitations to this approach. Here Loh et al. show that the Y1 receptor is expressed in β- cells and inhibition of its signalling, both genetic and pharmacological...

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Autores principales:	Kim Loh, Yan-Chuan Shi, Stacey Walters, Mohammed Bensellam, Kailun Lee, Katsuya Dezaki, Masanori Nakata, Chi Kin Ip, Jeng Yie Chan, Esteban N. Gurzov, Helen E. Thomas, Michaela Waibel, James Cantley, Thomas W. Kay, Toshihiko Yada, D. Ross Laybutt, Shane T. Grey, Herbert Herzog
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/99ec06e40ce64866b58ef492f2dc58bd
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spelling	oai:doaj.org-article:99ec06e40ce64866b58ef492f2dc58bd2021-12-02T15:38:52ZInhibition of Y1 receptor signaling improves islet transplant outcome10.1038/s41467-017-00624-22041-1723https://doaj.org/article/99ec06e40ce64866b58ef492f2dc58bd2017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00624-2https://doaj.org/toc/2041-1723Islet transplantation is considered one of the potential treatments for T1DM but limited islet survival and their impaired function pose limitations to this approach. Here Loh et al. show that the Y1 receptor is expressed in β- cells and inhibition of its signalling, both genetic and pharmacological, improves mouse and human islet function.Kim LohYan-Chuan ShiStacey WaltersMohammed BensellamKailun LeeKatsuya DezakiMasanori NakataChi Kin IpJeng Yie ChanEsteban N. GurzovHelen E. ThomasMichaela WaibelJames CantleyThomas W. KayToshihiko YadaD. Ross LaybuttShane T. GreyHerbert HerzogNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kim Loh Yan-Chuan Shi Stacey Walters Mohammed Bensellam Kailun Lee Katsuya Dezaki Masanori Nakata Chi Kin Ip Jeng Yie Chan Esteban N. Gurzov Helen E. Thomas Michaela Waibel James Cantley Thomas W. Kay Toshihiko Yada D. Ross Laybutt Shane T. Grey Herbert Herzog Inhibition of Y1 receptor signaling improves islet transplant outcome
description	Islet transplantation is considered one of the potential treatments for T1DM but limited islet survival and their impaired function pose limitations to this approach. Here Loh et al. show that the Y1 receptor is expressed in β- cells and inhibition of its signalling, both genetic and pharmacological, improves mouse and human islet function.
format	article
author	Kim Loh Yan-Chuan Shi Stacey Walters Mohammed Bensellam Kailun Lee Katsuya Dezaki Masanori Nakata Chi Kin Ip Jeng Yie Chan Esteban N. Gurzov Helen E. Thomas Michaela Waibel James Cantley Thomas W. Kay Toshihiko Yada D. Ross Laybutt Shane T. Grey Herbert Herzog
author_facet	Kim Loh Yan-Chuan Shi Stacey Walters Mohammed Bensellam Kailun Lee Katsuya Dezaki Masanori Nakata Chi Kin Ip Jeng Yie Chan Esteban N. Gurzov Helen E. Thomas Michaela Waibel James Cantley Thomas W. Kay Toshihiko Yada D. Ross Laybutt Shane T. Grey Herbert Herzog
author_sort	Kim Loh
title	Inhibition of Y1 receptor signaling improves islet transplant outcome
title_short	Inhibition of Y1 receptor signaling improves islet transplant outcome
title_full	Inhibition of Y1 receptor signaling improves islet transplant outcome
title_fullStr	Inhibition of Y1 receptor signaling improves islet transplant outcome
title_full_unstemmed	Inhibition of Y1 receptor signaling improves islet transplant outcome
title_sort	inhibition of y1 receptor signaling improves islet transplant outcome
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/99ec06e40ce64866b58ef492f2dc58bd
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Inhibition of Y1 receptor signaling improves islet transplant outcome

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