Mammographic density, blood telomere length and lipid peroxidation

Abstract Extensive mammographic density is a strong risk factor for breast cancer, but may also be an indicator of biological age. In this study we examined whether mammographic density is related to blood telomere length, a potential marker of susceptibility to age-related disease. We measured mamm...

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Autores principales:	Natalie J. Erdmann, Lea A. Harrington, Lisa J. Martin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/99ee510e07a140c4ab8989684630a11e
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spelling	oai:doaj.org-article:99ee510e07a140c4ab8989684630a11e2021-12-02T15:05:24ZMammographic density, blood telomere length and lipid peroxidation10.1038/s41598-017-06036-y2045-2322https://doaj.org/article/99ee510e07a140c4ab8989684630a11e2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06036-yhttps://doaj.org/toc/2045-2322Abstract Extensive mammographic density is a strong risk factor for breast cancer, but may also be an indicator of biological age. In this study we examined whether mammographic density is related to blood telomere length, a potential marker of susceptibility to age-related disease. We measured mammographic density by a computer assisted method and blood telomere length using a validated PCR method. Urinary malondialdehyde (MDA), a marker of lipid peroxidation, was measured in 24 hour urine collections. In the 342 women examined telomere length was negatively correlated with age, was lower in postmenopausal compared to premenopausal women and in smokers compared to non-smokers, and was positively correlated with urinary MDA. Telomere length was not associated with percent mammographic density or dense area, before or after adjustment for risk factors and MDA. However, there was a significant interaction between telomere length and MDA in their association with mammographic density. At lower levels of MDA, mammographic density and telomere length were inversely associated; while at high levels of MDA, there was evidence of a J-shaped association between mammographic density and telomere length. Further work is need to replicate these results and to examine the association of mammographic density with age-related chronic disease and mortality.Natalie J. ErdmannLea A. HarringtonLisa J. MartinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Natalie J. Erdmann Lea A. Harrington Lisa J. Martin Mammographic density, blood telomere length and lipid peroxidation
description	Abstract Extensive mammographic density is a strong risk factor for breast cancer, but may also be an indicator of biological age. In this study we examined whether mammographic density is related to blood telomere length, a potential marker of susceptibility to age-related disease. We measured mammographic density by a computer assisted method and blood telomere length using a validated PCR method. Urinary malondialdehyde (MDA), a marker of lipid peroxidation, was measured in 24 hour urine collections. In the 342 women examined telomere length was negatively correlated with age, was lower in postmenopausal compared to premenopausal women and in smokers compared to non-smokers, and was positively correlated with urinary MDA. Telomere length was not associated with percent mammographic density or dense area, before or after adjustment for risk factors and MDA. However, there was a significant interaction between telomere length and MDA in their association with mammographic density. At lower levels of MDA, mammographic density and telomere length were inversely associated; while at high levels of MDA, there was evidence of a J-shaped association between mammographic density and telomere length. Further work is need to replicate these results and to examine the association of mammographic density with age-related chronic disease and mortality.
format	article
author	Natalie J. Erdmann Lea A. Harrington Lisa J. Martin
author_facet	Natalie J. Erdmann Lea A. Harrington Lisa J. Martin
author_sort	Natalie J. Erdmann
title	Mammographic density, blood telomere length and lipid peroxidation
title_short	Mammographic density, blood telomere length and lipid peroxidation
title_full	Mammographic density, blood telomere length and lipid peroxidation
title_fullStr	Mammographic density, blood telomere length and lipid peroxidation
title_full_unstemmed	Mammographic density, blood telomere length and lipid peroxidation
title_sort	mammographic density, blood telomere length and lipid peroxidation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/99ee510e07a140c4ab8989684630a11e
work_keys_str_mv	AT nataliejerdmann mammographicdensitybloodtelomerelengthandlipidperoxidation AT leaaharrington mammographicdensitybloodtelomerelengthandlipidperoxidation AT lisajmartin mammographicdensitybloodtelomerelengthandlipidperoxidation
_version_	1718388848373792768

Mammographic density, blood telomere length and lipid peroxidation

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