Genetics of clusterin isoform expression and Alzheimer's disease risk.

Genetics of clusterin isoform expression and Alzheimer's disease risk.

The minor allele of rs11136000 within CLU is strongly associated with reduced Alzheimer's disease (AD) risk. The mechanism underlying this association is unclear. Here, we report that CLU1 and CLU2 are the two primary CLU isoforms in human brain; CLU1 and CLU2 share exons 2-9 but differ in exon...

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Autores principales: I-Fang Ling, Jiraganya Bhongsatiern, James F Simpson, David W Fardo, Steven Estus
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/99ee7dac0e6d4d618827f496ed6cc3a5
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