Structural basis of human ghrelin receptor signaling by ghrelin and the synthetic agonist ibutamoren

Ghrelin is a central orexigenic peptide hormone in human energy homeostasis that is also known as ‘hunger hormone’ and signals through its GPCR, GHSR. Here, the authors present the cryo-EM structures of the human GHSR-Gi signaling complex with bound ghrelin and the synthetic non-peptide agonist ibut...

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Autores principales:	Heng Liu, Dapeng Sun, Alexander Myasnikov, Marjorie Damian, Jean-Louis Baneres, Ji Sun, Cheng Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/99f1bc64dbea43bd809cc656f733f728
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spelling	oai:doaj.org-article:99f1bc64dbea43bd809cc656f733f7282021-11-08T11:06:14ZStructural basis of human ghrelin receptor signaling by ghrelin and the synthetic agonist ibutamoren10.1038/s41467-021-26735-52041-1723https://doaj.org/article/99f1bc64dbea43bd809cc656f733f7282021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26735-5https://doaj.org/toc/2041-1723Ghrelin is a central orexigenic peptide hormone in human energy homeostasis that is also known as ‘hunger hormone’ and signals through its GPCR, GHSR. Here, the authors present the cryo-EM structures of the human GHSR-Gi signaling complex with bound ghrelin and the synthetic non-peptide agonist ibutamoren that are of interest for drug design.Heng LiuDapeng SunAlexander MyasnikovMarjorie DamianJean-Louis BaneresJi SunCheng ZhangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Heng Liu Dapeng Sun Alexander Myasnikov Marjorie Damian Jean-Louis Baneres Ji Sun Cheng Zhang Structural basis of human ghrelin receptor signaling by ghrelin and the synthetic agonist ibutamoren
description	Ghrelin is a central orexigenic peptide hormone in human energy homeostasis that is also known as ‘hunger hormone’ and signals through its GPCR, GHSR. Here, the authors present the cryo-EM structures of the human GHSR-Gi signaling complex with bound ghrelin and the synthetic non-peptide agonist ibutamoren that are of interest for drug design.
format	article
author	Heng Liu Dapeng Sun Alexander Myasnikov Marjorie Damian Jean-Louis Baneres Ji Sun Cheng Zhang
author_facet	Heng Liu Dapeng Sun Alexander Myasnikov Marjorie Damian Jean-Louis Baneres Ji Sun Cheng Zhang
author_sort	Heng Liu
title	Structural basis of human ghrelin receptor signaling by ghrelin and the synthetic agonist ibutamoren
title_short	Structural basis of human ghrelin receptor signaling by ghrelin and the synthetic agonist ibutamoren
title_full	Structural basis of human ghrelin receptor signaling by ghrelin and the synthetic agonist ibutamoren
title_fullStr	Structural basis of human ghrelin receptor signaling by ghrelin and the synthetic agonist ibutamoren
title_full_unstemmed	Structural basis of human ghrelin receptor signaling by ghrelin and the synthetic agonist ibutamoren
title_sort	structural basis of human ghrelin receptor signaling by ghrelin and the synthetic agonist ibutamoren
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/99f1bc64dbea43bd809cc656f733f728
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Structural basis of human ghrelin receptor signaling by ghrelin and the synthetic agonist ibutamoren

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