Cytokine Response in SARS-CoV-2 Infection in the Elderly

Subuhi Sherwani,1 Mohd Wajid Ali Khan2 1Department of Biology, College of Sciences, University of Ha’il, Ha’il 2440, Saudi Arabia; 2Department of Chemistry, College of Sciences, University of Ha’il, Ha’il 2440, Saudi ArabiaCorrespondence: Subuhi SherwaniDepart...

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Autores principales:	Sherwani S, Khan MWA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	sars-cov-2 covid-19 coronavirus cytokine storm inflammation elderly Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/99f44480f1bf401d979ba38d2a2060c3
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spelling	oai:doaj.org-article:99f44480f1bf401d979ba38d2a2060c32021-12-02T13:05:57ZCytokine Response in SARS-CoV-2 Infection in the Elderly1178-7031https://doaj.org/article/99f44480f1bf401d979ba38d2a2060c32020-10-01T00:00:00Zhttps://www.dovepress.com/cytokine-response-in-sars-cov-2-infection-in-the-elderly-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Subuhi Sherwani,1 Mohd Wajid Ali Khan2 1Department of Biology, College of Sciences, University of Ha’il, Ha’il 2440, Saudi Arabia; 2Department of Chemistry, College of Sciences, University of Ha’il, Ha’il 2440, Saudi ArabiaCorrespondence: Subuhi SherwaniDepartment of Biology, College of Sciences, University of Ha’il, Ha’il 2440, Saudi ArabiaTel +966-590172770Email susherwani@gmail.comAbstract: The last few months of 2019 witnessed the emergence, rise and rapid spread of a novel coronavirus known as severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), causing an acute respiratory disease called coronavirus disease 2019 or Covid-19. Severe pathological manifestations of the disease in the infected population with comorbidities are linked to acute respiratory distress syndrome (ARDS), associated with an exaggerated synthesis and expression of cytokines, leading to a systemic inflammatory response also known as a cytokine storm (CS). Elderly patients (> 60 years of age) showed more deaths in Covid-19 infection. Age-related immune imbalance increases patient susceptibility to CS. In acute Covid-19 infection, it is difficult to minimize or control the overproduction of cytokines; hence, limited medical treatments are effective. This review aims to provide an overview of the current knowledge of involvement of cytokines in SARS-CoV-2 infection, susceptibility factors for the accompanying cytokine storm in severe Covid-19 cases and possible treatment strategies.Keywords: SARS-CoV-2, Covid-19, coronavirus, cytokine storm, inflammation, elderlySherwani SKhan MWADove Medical Pressarticlesars-cov-2covid-19coronaviruscytokine storminflammationelderlyPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 13, Pp 737-747 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	sars-cov-2 covid-19 coronavirus cytokine storm inflammation elderly Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	sars-cov-2 covid-19 coronavirus cytokine storm inflammation elderly Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Sherwani S Khan MWA Cytokine Response in SARS-CoV-2 Infection in the Elderly
description	Subuhi Sherwani,1 Mohd Wajid Ali Khan2 1Department of Biology, College of Sciences, University of Ha’il, Ha’il 2440, Saudi Arabia; 2Department of Chemistry, College of Sciences, University of Ha’il, Ha’il 2440, Saudi ArabiaCorrespondence: Subuhi SherwaniDepartment of Biology, College of Sciences, University of Ha’il, Ha’il 2440, Saudi ArabiaTel +966-590172770Email susherwani@gmail.comAbstract: The last few months of 2019 witnessed the emergence, rise and rapid spread of a novel coronavirus known as severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), causing an acute respiratory disease called coronavirus disease 2019 or Covid-19. Severe pathological manifestations of the disease in the infected population with comorbidities are linked to acute respiratory distress syndrome (ARDS), associated with an exaggerated synthesis and expression of cytokines, leading to a systemic inflammatory response also known as a cytokine storm (CS). Elderly patients (> 60 years of age) showed more deaths in Covid-19 infection. Age-related immune imbalance increases patient susceptibility to CS. In acute Covid-19 infection, it is difficult to minimize or control the overproduction of cytokines; hence, limited medical treatments are effective. This review aims to provide an overview of the current knowledge of involvement of cytokines in SARS-CoV-2 infection, susceptibility factors for the accompanying cytokine storm in severe Covid-19 cases and possible treatment strategies.Keywords: SARS-CoV-2, Covid-19, coronavirus, cytokine storm, inflammation, elderly
format	article
author	Sherwani S Khan MWA
author_facet	Sherwani S Khan MWA
author_sort	Sherwani S
title	Cytokine Response in SARS-CoV-2 Infection in the Elderly
title_short	Cytokine Response in SARS-CoV-2 Infection in the Elderly
title_full	Cytokine Response in SARS-CoV-2 Infection in the Elderly
title_fullStr	Cytokine Response in SARS-CoV-2 Infection in the Elderly
title_full_unstemmed	Cytokine Response in SARS-CoV-2 Infection in the Elderly
title_sort	cytokine response in sars-cov-2 infection in the elderly
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/99f44480f1bf401d979ba38d2a2060c3
work_keys_str_mv	AT sherwanis cytokineresponseinsarscov2infectionintheelderly AT khanmwa cytokineresponseinsarscov2infectionintheelderly
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Cytokine Response in SARS-CoV-2 Infection in the Elderly

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