The Plasmodium PI(4)K inhibitor KDU691 selectively inhibits dihydroartemisinin-pretreated Plasmodium falciparum ring-stage parasites

The Plasmodium PI(4)K inhibitor KDU691 selectively inhibits dihydroartemisinin-pretreated Plasmodium falciparum ring-stage parasites

Abstract Malaria control and elimination are threatened by the emergence and spread of resistance to artemisinin-based combination therapies (ACTs). Experimental evidence suggests that when an artemisinin (ART)-sensitive (K13 wild-type) Plasmodium falciparum strain is exposed to ART derivatives such...

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Autores principales: L. Dembele, X. Ang, M. Chavchich, G. M. C. Bonamy, J. J. Selva, M. Yi-Xiu Lim, C. Bodenreider, B. K. S. Yeung, F. Nosten, B. M. Russell, M. D. Edstein, J. Straimer, D. A. Fidock, T. T. Diagana, P. Bifani
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/99f7a3c6162945b384400f88d2d8584f
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