Ultrastructural alterations of megakaryocytes in thrombocytopenia: A review of 43 cases

Abstract. Thrombocytopenia is a frequent occurrence in a variety of hematopoietic diseases; however, the details of the mechanism leading to low platelet count remain elusive. Megakaryocytes are a series of progenitor cells responsible for the production of platelets. Alterations in megakaryocytes i...

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Autores principales:	Brian Eyden, Ru Yong-Xin, Shu-Xu Dong, Jing Liu, Xiao-Fan Liu
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Health 2021
Materias:	Diseases of the blood and blood-forming organs RC633-647.5
Acceso en línea:	https://doaj.org/article/99f8447a0b8a433fbadb89985d474368
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spelling	oai:doaj.org-article:99f8447a0b8a433fbadb89985d4743682021-11-25T07:49:34ZUltrastructural alterations of megakaryocytes in thrombocytopenia: A review of 43 cases2543-636810.1097/BS9.0000000000000093https://doaj.org/article/99f8447a0b8a433fbadb89985d4743682021-10-01T00:00:00Zhttp://journals.lww.com/10.1097/BS9.0000000000000093https://doaj.org/toc/2543-6368Abstract. Thrombocytopenia is a frequent occurrence in a variety of hematopoietic diseases; however, the details of the mechanism leading to low platelet count remain elusive. Megakaryocytes are a series of progenitor cells responsible for the production of platelets. Alterations in megakaryocytes in the bone marrow are a causative factor resulting in thrombocytopenia in varied diseases. Based on ultrastructural analysis of incidentally encountered megakaryocytes in 43 patients with blood diseases marked by low platelet counts, electron micrographs demonstrated that aberrant megakaryocytes predominated in idiopathic thrombocytopenic purpura, aplastic anemia, and myelodysplastic syndrome; autophagy, apoptosis, and cellular damage in megakaryocytes were a prominent feature in aplastic anemia. On the other hand, poorly differentiated megakaryocytes predominated in acute megakaryoblastic leukemia (AMKL) although damaged megakaryocytes were seen in non-AMKL acute leukemia. This paper documents the ultrastructural alterations of megakaryocytes associated with thrombocytopenia and reveals distinctive features for particular blood diseases. A comment is made on future avenues of research emphasizing membrane fusion proteins.Brian EydenRu Yong-XinShu-Xu DongJing LiuXiao-Fan LiuWolters Kluwer HealtharticleDiseases of the blood and blood-forming organsRC633-647.5ENBlood Science, Vol 3, Iss 4, Pp 107-112 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the blood and blood-forming organs RC633-647.5
spellingShingle	Diseases of the blood and blood-forming organs RC633-647.5 Brian Eyden Ru Yong-Xin Shu-Xu Dong Jing Liu Xiao-Fan Liu Ultrastructural alterations of megakaryocytes in thrombocytopenia: A review of 43 cases
description	Abstract. Thrombocytopenia is a frequent occurrence in a variety of hematopoietic diseases; however, the details of the mechanism leading to low platelet count remain elusive. Megakaryocytes are a series of progenitor cells responsible for the production of platelets. Alterations in megakaryocytes in the bone marrow are a causative factor resulting in thrombocytopenia in varied diseases. Based on ultrastructural analysis of incidentally encountered megakaryocytes in 43 patients with blood diseases marked by low platelet counts, electron micrographs demonstrated that aberrant megakaryocytes predominated in idiopathic thrombocytopenic purpura, aplastic anemia, and myelodysplastic syndrome; autophagy, apoptosis, and cellular damage in megakaryocytes were a prominent feature in aplastic anemia. On the other hand, poorly differentiated megakaryocytes predominated in acute megakaryoblastic leukemia (AMKL) although damaged megakaryocytes were seen in non-AMKL acute leukemia. This paper documents the ultrastructural alterations of megakaryocytes associated with thrombocytopenia and reveals distinctive features for particular blood diseases. A comment is made on future avenues of research emphasizing membrane fusion proteins.
format	article
author	Brian Eyden Ru Yong-Xin Shu-Xu Dong Jing Liu Xiao-Fan Liu
author_facet	Brian Eyden Ru Yong-Xin Shu-Xu Dong Jing Liu Xiao-Fan Liu
author_sort	Brian Eyden
title	Ultrastructural alterations of megakaryocytes in thrombocytopenia: A review of 43 cases
title_short	Ultrastructural alterations of megakaryocytes in thrombocytopenia: A review of 43 cases
title_full	Ultrastructural alterations of megakaryocytes in thrombocytopenia: A review of 43 cases
title_fullStr	Ultrastructural alterations of megakaryocytes in thrombocytopenia: A review of 43 cases
title_full_unstemmed	Ultrastructural alterations of megakaryocytes in thrombocytopenia: A review of 43 cases
title_sort	ultrastructural alterations of megakaryocytes in thrombocytopenia: a review of 43 cases
publisher	Wolters Kluwer Health
publishDate	2021
url	https://doaj.org/article/99f8447a0b8a433fbadb89985d474368
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Ultrastructural alterations of megakaryocytes in thrombocytopenia: A review of 43 cases

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