Discrimination between 34 of 36 Possible Combinations of Three C>T SNP Genotypes in the <i>MGMT</i> Promoter by High Resolution Melting Analysis Coupled with Pyrosequencing Using A Single Primer Set

Discrimination between 34 of 36 Possible Combinations of Three C>T SNP Genotypes in the <i>MGMT</i> Promoter by High Resolution Melting Analysis Coupled with Pyrosequencing Using A Single Primer Set

Due to its cost-efficiency, high resolution melting (HRM) analysis plays an important role in genotyping of candidate single nucleotide polymorphisms (SNPs). Studies indicate that HRM analysis is not only suitable for genotyping individual SNPs, but also allows genotyping of multiple SNPs in one and...

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Bibliographic Details
Main Authors: Katja Zappe, Christine Pirker, Heidi Miedl, Martin Schreiber, Petra Heffeter, Georg Pfeiler, Stefan Hacker, Werner Haslik, Sabine Spiegl-Kreinecker, Margit Cichna-Markl
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
genotyping
multiple SNPs
<i>MGMT</i>
high resolution melting
pyrosequencing
Biology (General)
QH301-705.5
Chemistry
QD1-999
Online Access:https://doaj.org/article/99f9b8069d9140af89247b2e53ecf2fe
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