PERIPHERAL BLOOD LYMPHOCYTE SUBPOPULATIONS AND CYTOKINE PROFILE IN PERIODONTITIS

Functional disorders of immune system are among potential reasons of periodontal disease, thus contributing to persistence of inflammatory infiltrate in periodontal tissues and resulting into chronic local inflammation. Disturbances of local and systemic immunity play an important role in the develo...

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Autores principales:	L. M. Tebloeva, O. A. Guseva, S. V. Khaidukov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	periodontitis flow cytometry cd45r0 il-17 srankl Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/9a00f2d913394f95a2d10eb4561344fb
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spelling	oai:doaj.org-article:9a00f2d913394f95a2d10eb4561344fb2021-11-18T08:03:44ZPERIPHERAL BLOOD LYMPHOCYTE SUBPOPULATIONS AND CYTOKINE PROFILE IN PERIODONTITIS1563-06252313-741X10.15789/1563-0625-2014-3-257-264https://doaj.org/article/9a00f2d913394f95a2d10eb4561344fb2014-08-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/691https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XFunctional disorders of immune system are among potential reasons of periodontal disease, thus contributing to persistence of inflammatory infiltrate in periodontal tissues and resulting into chronic local inflammation. Disturbances of local and systemic immunity play an important role in the development of periodontitis. Local immunoreactivity is associated with the induced expression of proinflammatory cytokines and attraction of pro-inflammatory cells. Systemic disorders are associated with changes in T-helper cell subpopulations, as well as those of CD3-CD8+ lymphocytes. Severity of inflammatory events and clinical course of periodontal disease is determined by qualitative and quantitative content of the T-helper cells, that express CD45RA and CD45RO antigens. Composition of T cell subsets shows direct correlations with cytokine profile in blood serum and crevicular fluid from gingival pockets. A higher IL-17 concentration, as well as increased IFNγ and IL-18 levels in blood serum of the patients suggest a potential autoimmune mechanism in periodontitis. Upon emergence and development of periodontitis, an important role may be ascribed to ‘osteocluster’ cytokines (sRANKL and OPG), and detecton of their relative contents in crevicular fluid may be proposed for testing, in order to predict clinical risks in periodontitis.L. M. TebloevaO. A. GusevaS. V. KhaidukovSPb RAACIarticleperiodontitisflow cytometrycd45r0il-17sranklImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 16, Iss 3, Pp 257-264 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	periodontitis flow cytometry cd45r0 il-17 srankl Immunologic diseases. Allergy RC581-607
spellingShingle	periodontitis flow cytometry cd45r0 il-17 srankl Immunologic diseases. Allergy RC581-607 L. M. Tebloeva O. A. Guseva S. V. Khaidukov PERIPHERAL BLOOD LYMPHOCYTE SUBPOPULATIONS AND CYTOKINE PROFILE IN PERIODONTITIS
description	Functional disorders of immune system are among potential reasons of periodontal disease, thus contributing to persistence of inflammatory infiltrate in periodontal tissues and resulting into chronic local inflammation. Disturbances of local and systemic immunity play an important role in the development of periodontitis. Local immunoreactivity is associated with the induced expression of proinflammatory cytokines and attraction of pro-inflammatory cells. Systemic disorders are associated with changes in T-helper cell subpopulations, as well as those of CD3-CD8+ lymphocytes. Severity of inflammatory events and clinical course of periodontal disease is determined by qualitative and quantitative content of the T-helper cells, that express CD45RA and CD45RO antigens. Composition of T cell subsets shows direct correlations with cytokine profile in blood serum and crevicular fluid from gingival pockets. A higher IL-17 concentration, as well as increased IFNγ and IL-18 levels in blood serum of the patients suggest a potential autoimmune mechanism in periodontitis. Upon emergence and development of periodontitis, an important role may be ascribed to ‘osteocluster’ cytokines (sRANKL and OPG), and detecton of their relative contents in crevicular fluid may be proposed for testing, in order to predict clinical risks in periodontitis.
format	article
author	L. M. Tebloeva O. A. Guseva S. V. Khaidukov
author_facet	L. M. Tebloeva O. A. Guseva S. V. Khaidukov
author_sort	L. M. Tebloeva
title	PERIPHERAL BLOOD LYMPHOCYTE SUBPOPULATIONS AND CYTOKINE PROFILE IN PERIODONTITIS
title_short	PERIPHERAL BLOOD LYMPHOCYTE SUBPOPULATIONS AND CYTOKINE PROFILE IN PERIODONTITIS
title_full	PERIPHERAL BLOOD LYMPHOCYTE SUBPOPULATIONS AND CYTOKINE PROFILE IN PERIODONTITIS
title_fullStr	PERIPHERAL BLOOD LYMPHOCYTE SUBPOPULATIONS AND CYTOKINE PROFILE IN PERIODONTITIS
title_full_unstemmed	PERIPHERAL BLOOD LYMPHOCYTE SUBPOPULATIONS AND CYTOKINE PROFILE IN PERIODONTITIS
title_sort	peripheral blood lymphocyte subpopulations and cytokine profile in periodontitis
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/9a00f2d913394f95a2d10eb4561344fb
work_keys_str_mv	AT lmtebloeva peripheralbloodlymphocytesubpopulationsandcytokineprofileinperiodontitis AT oaguseva peripheralbloodlymphocytesubpopulationsandcytokineprofileinperiodontitis AT svkhaidukov peripheralbloodlymphocytesubpopulationsandcytokineprofileinperiodontitis
_version_	1718422436435722240

PERIPHERAL BLOOD LYMPHOCYTE SUBPOPULATIONS AND CYTOKINE PROFILE IN PERIODONTITIS

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