Relationship between Oxytocin and Osteoarthritis: Hope or Despair?

Oxytocin (OT) is involved in breastfeeding and childbirth and appears to play a role in regulating the bone matrix. OT is synthesized in the supraoptic and paraventricular nuclei of the hypothalamus and is released in response to numerous stimuli. It also appears to be produced by osteoblasts in the...

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Autores principales:	Stephanie Ferrero, Ez-Zoubir Amri, Christian Hubert Roux
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	oxytocin osteoarthritis adipocytes chondrocytes Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/9a019f0c9e9b45d88eb24bc999caa535
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spelling	oai:doaj.org-article:9a019f0c9e9b45d88eb24bc999caa5352021-11-11T17:14:07ZRelationship between Oxytocin and Osteoarthritis: Hope or Despair?10.3390/ijms2221117841422-00671661-6596https://doaj.org/article/9a019f0c9e9b45d88eb24bc999caa5352021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11784https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Oxytocin (OT) is involved in breastfeeding and childbirth and appears to play a role in regulating the bone matrix. OT is synthesized in the supraoptic and paraventricular nuclei of the hypothalamus and is released in response to numerous stimuli. It also appears to be produced by osteoblasts in the bone marrow, acting as a paracrine–autocrine regulator of bone formation. Osteoarthritis (OA) is a disease of the whole joint. Different tissues involved in OA express OT receptors (OTRs), such as chondrocytes and osteoblasts. This hormone, which levels are reduced in patients with OA, appears to have a stimulatory effect on chondrogenesis. OT involvement in bone biology could occur at both the osteoblast and chondrocyte levels. The relationships between metabolic syndrome, body weight, and OA are well documented, and the possible effects of OT on different parameters of metabolic syndrome, such as diabetes and body weight, are important. In addition, the effects of OT on adipokines and inflammation are also discussed, especially since recent data have shown that low-grade inflammation is also associated with OA. Furthermore, OT also appears to mediate endogenous analgesia in animal and human studies. These observations provide support for the possible interest of OT in OA and its potential therapeutic treatment.Stephanie FerreroEz-Zoubir AmriChristian Hubert RouxMDPI AGarticleoxytocinosteoarthritisadipocyteschondrocytesBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11784, p 11784 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	oxytocin osteoarthritis adipocytes chondrocytes Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	oxytocin osteoarthritis adipocytes chondrocytes Biology (General) QH301-705.5 Chemistry QD1-999 Stephanie Ferrero Ez-Zoubir Amri Christian Hubert Roux Relationship between Oxytocin and Osteoarthritis: Hope or Despair?
description	Oxytocin (OT) is involved in breastfeeding and childbirth and appears to play a role in regulating the bone matrix. OT is synthesized in the supraoptic and paraventricular nuclei of the hypothalamus and is released in response to numerous stimuli. It also appears to be produced by osteoblasts in the bone marrow, acting as a paracrine–autocrine regulator of bone formation. Osteoarthritis (OA) is a disease of the whole joint. Different tissues involved in OA express OT receptors (OTRs), such as chondrocytes and osteoblasts. This hormone, which levels are reduced in patients with OA, appears to have a stimulatory effect on chondrogenesis. OT involvement in bone biology could occur at both the osteoblast and chondrocyte levels. The relationships between metabolic syndrome, body weight, and OA are well documented, and the possible effects of OT on different parameters of metabolic syndrome, such as diabetes and body weight, are important. In addition, the effects of OT on adipokines and inflammation are also discussed, especially since recent data have shown that low-grade inflammation is also associated with OA. Furthermore, OT also appears to mediate endogenous analgesia in animal and human studies. These observations provide support for the possible interest of OT in OA and its potential therapeutic treatment.
format	article
author	Stephanie Ferrero Ez-Zoubir Amri Christian Hubert Roux
author_facet	Stephanie Ferrero Ez-Zoubir Amri Christian Hubert Roux
author_sort	Stephanie Ferrero
title	Relationship between Oxytocin and Osteoarthritis: Hope or Despair?
title_short	Relationship between Oxytocin and Osteoarthritis: Hope or Despair?
title_full	Relationship between Oxytocin and Osteoarthritis: Hope or Despair?
title_fullStr	Relationship between Oxytocin and Osteoarthritis: Hope or Despair?
title_full_unstemmed	Relationship between Oxytocin and Osteoarthritis: Hope or Despair?
title_sort	relationship between oxytocin and osteoarthritis: hope or despair?
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/9a019f0c9e9b45d88eb24bc999caa535
work_keys_str_mv	AT stephanieferrero relationshipbetweenoxytocinandosteoarthritishopeordespair AT ezzoubiramri relationshipbetweenoxytocinandosteoarthritishopeordespair AT christianhubertroux relationshipbetweenoxytocinandosteoarthritishopeordespair
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Relationship between Oxytocin and Osteoarthritis: Hope or Despair?

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