Machine learning uncovers cell identity regulator by histone code

Identification of genes that determine and regulate cell identity remains challenging. Here, the authors use machine learning to identify cell identity genes and master regulator transcription factors based on gene expression profiles and histone modifications.

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Autores principales:	Bo Xia, Dongyu Zhao, Guangyu Wang, Min Zhang, Jie Lv, Alin S. Tomoiaga, Yanqiang Li, Xin Wang, Shu Meng, John P. Cooke, Qi Cao, Lili Zhang, Kaifu Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9a053b7a11724a1a815e60f452301743
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spelling	oai:doaj.org-article:9a053b7a11724a1a815e60f4523017432021-12-02T15:56:47ZMachine learning uncovers cell identity regulator by histone code10.1038/s41467-020-16539-42041-1723https://doaj.org/article/9a053b7a11724a1a815e60f4523017432020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16539-4https://doaj.org/toc/2041-1723Identification of genes that determine and regulate cell identity remains challenging. Here, the authors use machine learning to identify cell identity genes and master regulator transcription factors based on gene expression profiles and histone modifications.Bo XiaDongyu ZhaoGuangyu WangMin ZhangJie LvAlin S. TomoiagaYanqiang LiXin WangShu MengJohn P. CookeQi CaoLili ZhangKaifu ChenNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bo Xia Dongyu Zhao Guangyu Wang Min Zhang Jie Lv Alin S. Tomoiaga Yanqiang Li Xin Wang Shu Meng John P. Cooke Qi Cao Lili Zhang Kaifu Chen Machine learning uncovers cell identity regulator by histone code
description	Identification of genes that determine and regulate cell identity remains challenging. Here, the authors use machine learning to identify cell identity genes and master regulator transcription factors based on gene expression profiles and histone modifications.
format	article
author	Bo Xia Dongyu Zhao Guangyu Wang Min Zhang Jie Lv Alin S. Tomoiaga Yanqiang Li Xin Wang Shu Meng John P. Cooke Qi Cao Lili Zhang Kaifu Chen
author_facet	Bo Xia Dongyu Zhao Guangyu Wang Min Zhang Jie Lv Alin S. Tomoiaga Yanqiang Li Xin Wang Shu Meng John P. Cooke Qi Cao Lili Zhang Kaifu Chen
author_sort	Bo Xia
title	Machine learning uncovers cell identity regulator by histone code
title_short	Machine learning uncovers cell identity regulator by histone code
title_full	Machine learning uncovers cell identity regulator by histone code
title_fullStr	Machine learning uncovers cell identity regulator by histone code
title_full_unstemmed	Machine learning uncovers cell identity regulator by histone code
title_sort	machine learning uncovers cell identity regulator by histone code
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/9a053b7a11724a1a815e60f452301743
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Machine learning uncovers cell identity regulator by histone code

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