Radiologic Assessment of Muscle and Fat Stores in Long-Term Type I Diabetics Referred for Pancreas Transplant Compared to Healthy Controls

Santosh Nagaraju, Richard S Mangus, Tyra A Salisbury, Weston J Bush, Jason P Davis, John A Powelson, Jonathan A Fridell Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USACorrespondence: Richard S Mangus Email rmangus@iupui.eduAbstract: Type 1 diabetes (DM1) is associ...

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Autores principales:	Nagaraju S, Mangus RS, Salisbury TA, Bush WJ, Davis JP, Powelson JA, Fridell JA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	computed tomography sarcopenia sarcopenic obesity nutrition type 1 diabetes Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/9a05db3705514b79addd4cff07411da6
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spelling	oai:doaj.org-article:9a05db3705514b79addd4cff07411da62021-12-02T15:42:46ZRadiologic Assessment of Muscle and Fat Stores in Long-Term Type I Diabetics Referred for Pancreas Transplant Compared to Healthy Controls1178-7007https://doaj.org/article/9a05db3705514b79addd4cff07411da62020-08-01T00:00:00Zhttps://www.dovepress.com/radiologic-assessment-of-muscle-and-fat-stores-in-long-term-type-i-dia-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Santosh Nagaraju, Richard S Mangus, Tyra A Salisbury, Weston J Bush, Jason P Davis, John A Powelson, Jonathan A Fridell Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USACorrespondence: Richard S Mangus Email rmangus@iupui.eduAbstract: Type 1 diabetes (DM1) is associated with loss of skeletal muscle and bone mass and may affect body fat stores. This study employs computed tomography (CT) scans to assess the body composition of DM1 patients referred for pancreas transplant compared to healthy controls. A 1:1 case–control design matched study patients with otherwise healthy patients from the trauma database. Matching criteria included age ± 5 years, gender, and body mass index (BMI) ± 2kg/m2. Nutrition variables included serum albumin and protein levels, BMI, and CT measures of muscle mass and fat stores. There were 22 subjects and 22 controls (median DM1 duration 24 years). DM1 patients had less muscle mass and less subcutaneous fat but no difference in visceral fat. Patients with the greatest muscle deficit were those with DM1 greater than 20 years and those younger than age 40. DM1 patients maintain similar BMI and protein levels compared to healthy controls but have marked deficits of muscle and subcutaneous fat. These results inform the nutritional management of DM1 patients and quantify the muscle and fat deficits present in these patients. At highest risk are young patients and those with duration of DM1 over 20 years.Keywords: computed tomography, sarcopenia, sarcopenic obesity, nutrition, type 1 diabetesNagaraju SMangus RSSalisbury TABush WJDavis JPPowelson JAFridell JADove Medical Pressarticlecomputed tomography sarcopenia sarcopenic obesity nutrition type 1 diabetesSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 2989-2995 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	computed tomography sarcopenia sarcopenic obesity nutrition type 1 diabetes Specialties of internal medicine RC581-951
spellingShingle	computed tomography sarcopenia sarcopenic obesity nutrition type 1 diabetes Specialties of internal medicine RC581-951 Nagaraju S Mangus RS Salisbury TA Bush WJ Davis JP Powelson JA Fridell JA Radiologic Assessment of Muscle and Fat Stores in Long-Term Type I Diabetics Referred for Pancreas Transplant Compared to Healthy Controls
description	Santosh Nagaraju, Richard S Mangus, Tyra A Salisbury, Weston J Bush, Jason P Davis, John A Powelson, Jonathan A Fridell Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USACorrespondence: Richard S Mangus Email rmangus@iupui.eduAbstract: Type 1 diabetes (DM1) is associated with loss of skeletal muscle and bone mass and may affect body fat stores. This study employs computed tomography (CT) scans to assess the body composition of DM1 patients referred for pancreas transplant compared to healthy controls. A 1:1 case–control design matched study patients with otherwise healthy patients from the trauma database. Matching criteria included age ± 5 years, gender, and body mass index (BMI) ± 2kg/m2. Nutrition variables included serum albumin and protein levels, BMI, and CT measures of muscle mass and fat stores. There were 22 subjects and 22 controls (median DM1 duration 24 years). DM1 patients had less muscle mass and less subcutaneous fat but no difference in visceral fat. Patients with the greatest muscle deficit were those with DM1 greater than 20 years and those younger than age 40. DM1 patients maintain similar BMI and protein levels compared to healthy controls but have marked deficits of muscle and subcutaneous fat. These results inform the nutritional management of DM1 patients and quantify the muscle and fat deficits present in these patients. At highest risk are young patients and those with duration of DM1 over 20 years.Keywords: computed tomography, sarcopenia, sarcopenic obesity, nutrition, type 1 diabetes
format	article
author	Nagaraju S Mangus RS Salisbury TA Bush WJ Davis JP Powelson JA Fridell JA
author_facet	Nagaraju S Mangus RS Salisbury TA Bush WJ Davis JP Powelson JA Fridell JA
author_sort	Nagaraju S
title	Radiologic Assessment of Muscle and Fat Stores in Long-Term Type I Diabetics Referred for Pancreas Transplant Compared to Healthy Controls
title_short	Radiologic Assessment of Muscle and Fat Stores in Long-Term Type I Diabetics Referred for Pancreas Transplant Compared to Healthy Controls
title_full	Radiologic Assessment of Muscle and Fat Stores in Long-Term Type I Diabetics Referred for Pancreas Transplant Compared to Healthy Controls
title_fullStr	Radiologic Assessment of Muscle and Fat Stores in Long-Term Type I Diabetics Referred for Pancreas Transplant Compared to Healthy Controls
title_full_unstemmed	Radiologic Assessment of Muscle and Fat Stores in Long-Term Type I Diabetics Referred for Pancreas Transplant Compared to Healthy Controls
title_sort	radiologic assessment of muscle and fat stores in long-term type i diabetics referred for pancreas transplant compared to healthy controls
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/9a05db3705514b79addd4cff07411da6
work_keys_str_mv	AT nagarajus radiologicassessmentofmuscleandfatstoresinlongtermtypeidiabeticsreferredforpancreastransplantcomparedtohealthycontrols AT mangusrs radiologicassessmentofmuscleandfatstoresinlongtermtypeidiabeticsreferredforpancreastransplantcomparedtohealthycontrols AT salisburyta radiologicassessmentofmuscleandfatstoresinlongtermtypeidiabeticsreferredforpancreastransplantcomparedtohealthycontrols AT bushwj radiologicassessmentofmuscleandfatstoresinlongtermtypeidiabeticsreferredforpancreastransplantcomparedtohealthycontrols AT davisjp radiologicassessmentofmuscleandfatstoresinlongtermtypeidiabeticsreferredforpancreastransplantcomparedtohealthycontrols AT powelsonja radiologicassessmentofmuscleandfatstoresinlongtermtypeidiabeticsreferredforpancreastransplantcomparedtohealthycontrols AT fridellja radiologicassessmentofmuscleandfatstoresinlongtermtypeidiabeticsreferredforpancreastransplantcomparedtohealthycontrols
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Radiologic Assessment of Muscle and Fat Stores in Long-Term Type I Diabetics Referred for Pancreas Transplant Compared to Healthy Controls

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