Aberrant Post-Transcriptional Regulation of Protein Expression in the Development of Chronic Obstructive Pulmonary Disease

Chronic obstructive pulmonary disease (COPD) is an incurable and prevalent respiratory disorder that is characterized by chronic inflammation and emphysema. COPD is primarily caused by cigarette smoke (CS). CS alters numerous cellular processes, including the post-transcriptional regulation of mRNAs...

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Autores principales:	Noof Aloufi, Aeshah Alluli, David H. Eidelman, Carolyn J. Baglole
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	post-transcriptional regulation RNA binding proteins miRNAs COPD Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/9a08d1e4925c4e7a8a260e23df43f041
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spelling	oai:doaj.org-article:9a08d1e4925c4e7a8a260e23df43f0412021-11-11T17:23:04ZAberrant Post-Transcriptional Regulation of Protein Expression in the Development of Chronic Obstructive Pulmonary Disease10.3390/ijms2221119631422-00671661-6596https://doaj.org/article/9a08d1e4925c4e7a8a260e23df43f0412021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11963https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Chronic obstructive pulmonary disease (COPD) is an incurable and prevalent respiratory disorder that is characterized by chronic inflammation and emphysema. COPD is primarily caused by cigarette smoke (CS). CS alters numerous cellular processes, including the post-transcriptional regulation of mRNAs. The identification of RNA-binding proteins (RBPs), microRNAs (miRNAs), and long non-coding RNAs (lncRNAs) as main factors engaged in the regulation of RNA biology opens the door to understanding their role in coordinating physiological cellular processes. Dysregulation of post-transcriptional regulation by foreign particles in CS may lead to the development of diseases such as COPD. Here we review current knowledge about post-transcriptional events that may be involved in the pathogenesis of COPD.Noof AloufiAeshah AlluliDavid H. EidelmanCarolyn J. BagloleMDPI AGarticlepost-transcriptional regulationRNA binding proteinsmiRNAsCOPDBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11963, p 11963 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	post-transcriptional regulation RNA binding proteins miRNAs COPD Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	post-transcriptional regulation RNA binding proteins miRNAs COPD Biology (General) QH301-705.5 Chemistry QD1-999 Noof Aloufi Aeshah Alluli David H. Eidelman Carolyn J. Baglole Aberrant Post-Transcriptional Regulation of Protein Expression in the Development of Chronic Obstructive Pulmonary Disease
description	Chronic obstructive pulmonary disease (COPD) is an incurable and prevalent respiratory disorder that is characterized by chronic inflammation and emphysema. COPD is primarily caused by cigarette smoke (CS). CS alters numerous cellular processes, including the post-transcriptional regulation of mRNAs. The identification of RNA-binding proteins (RBPs), microRNAs (miRNAs), and long non-coding RNAs (lncRNAs) as main factors engaged in the regulation of RNA biology opens the door to understanding their role in coordinating physiological cellular processes. Dysregulation of post-transcriptional regulation by foreign particles in CS may lead to the development of diseases such as COPD. Here we review current knowledge about post-transcriptional events that may be involved in the pathogenesis of COPD.
format	article
author	Noof Aloufi Aeshah Alluli David H. Eidelman Carolyn J. Baglole
author_facet	Noof Aloufi Aeshah Alluli David H. Eidelman Carolyn J. Baglole
author_sort	Noof Aloufi
title	Aberrant Post-Transcriptional Regulation of Protein Expression in the Development of Chronic Obstructive Pulmonary Disease
title_short	Aberrant Post-Transcriptional Regulation of Protein Expression in the Development of Chronic Obstructive Pulmonary Disease
title_full	Aberrant Post-Transcriptional Regulation of Protein Expression in the Development of Chronic Obstructive Pulmonary Disease
title_fullStr	Aberrant Post-Transcriptional Regulation of Protein Expression in the Development of Chronic Obstructive Pulmonary Disease
title_full_unstemmed	Aberrant Post-Transcriptional Regulation of Protein Expression in the Development of Chronic Obstructive Pulmonary Disease
title_sort	aberrant post-transcriptional regulation of protein expression in the development of chronic obstructive pulmonary disease
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/9a08d1e4925c4e7a8a260e23df43f041
work_keys_str_mv	AT noofaloufi aberrantposttranscriptionalregulationofproteinexpressioninthedevelopmentofchronicobstructivepulmonarydisease AT aeshahalluli aberrantposttranscriptionalregulationofproteinexpressioninthedevelopmentofchronicobstructivepulmonarydisease AT davidheidelman aberrantposttranscriptionalregulationofproteinexpressioninthedevelopmentofchronicobstructivepulmonarydisease AT carolynjbaglole aberrantposttranscriptionalregulationofproteinexpressioninthedevelopmentofchronicobstructivepulmonarydisease
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Aberrant Post-Transcriptional Regulation of Protein Expression in the Development of Chronic Obstructive Pulmonary Disease

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