Perfluorooctane sulfonate affects intestinal immunity against bacterial infection

Abstract Perfluorooctane sulfonate (PFOS) is an environmental contaminant that has been manufactured to be used as surfactants and repellents in industry. Due to long half-life for clearance and degradation, PFOS is accumulative in human body and has potential threat to human health. Previous studie...

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Autores principales:	Caixia Suo, Zhiqin Fan, Liang Zhou, Ju Qiu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9a0b6495da0c4a4a8105a707fda58a78
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spelling	oai:doaj.org-article:9a0b6495da0c4a4a8105a707fda58a782021-12-02T15:05:58ZPerfluorooctane sulfonate affects intestinal immunity against bacterial infection10.1038/s41598-017-04091-z2045-2322https://doaj.org/article/9a0b6495da0c4a4a8105a707fda58a782017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04091-zhttps://doaj.org/toc/2045-2322Abstract Perfluorooctane sulfonate (PFOS) is an environmental contaminant that has been manufactured to be used as surfactants and repellents in industry. Due to long half-life for clearance and degradation, PFOS is accumulative in human body and has potential threat to human health. Previous studies have shown the development and function of immune cells can be affected by PFOS. Although PFOS has a high chance of being absorbed through the oral route, whether and how PFOS affects immune cells in the gut is unknown. Using mouse model of Citrobacter rodentium infection, we investigated the role of PFOS on intestinal immunity. We found at early phase of the infection, PFOS inhibited the expansion of the pathogen by promoting IL-22 production from the group 3 innate lymphoid cell (ILC3) in an aryl hydrocarbon receptor dependent manner. Nevertheless, persistent PFOS treatment in mice finally led to a failure to clear the pathogen completely. At late phase of infection, enhanced bacterial counts in PFOS treated mice were accompanied by increased inflammatory cytokines, reduced mucin production and dysbiosis, featured by decreased level of Lactobacillus casei, Lactobacillus johnsonii and increased E. coli. Our study reveals a deleterious consequence in intestinal bacterial infection caused by PFOS accumulation.Caixia SuoZhiqin FanLiang ZhouJu QiuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Caixia Suo Zhiqin Fan Liang Zhou Ju Qiu Perfluorooctane sulfonate affects intestinal immunity against bacterial infection
description	Abstract Perfluorooctane sulfonate (PFOS) is an environmental contaminant that has been manufactured to be used as surfactants and repellents in industry. Due to long half-life for clearance and degradation, PFOS is accumulative in human body and has potential threat to human health. Previous studies have shown the development and function of immune cells can be affected by PFOS. Although PFOS has a high chance of being absorbed through the oral route, whether and how PFOS affects immune cells in the gut is unknown. Using mouse model of Citrobacter rodentium infection, we investigated the role of PFOS on intestinal immunity. We found at early phase of the infection, PFOS inhibited the expansion of the pathogen by promoting IL-22 production from the group 3 innate lymphoid cell (ILC3) in an aryl hydrocarbon receptor dependent manner. Nevertheless, persistent PFOS treatment in mice finally led to a failure to clear the pathogen completely. At late phase of infection, enhanced bacterial counts in PFOS treated mice were accompanied by increased inflammatory cytokines, reduced mucin production and dysbiosis, featured by decreased level of Lactobacillus casei, Lactobacillus johnsonii and increased E. coli. Our study reveals a deleterious consequence in intestinal bacterial infection caused by PFOS accumulation.
format	article
author	Caixia Suo Zhiqin Fan Liang Zhou Ju Qiu
author_facet	Caixia Suo Zhiqin Fan Liang Zhou Ju Qiu
author_sort	Caixia Suo
title	Perfluorooctane sulfonate affects intestinal immunity against bacterial infection
title_short	Perfluorooctane sulfonate affects intestinal immunity against bacterial infection
title_full	Perfluorooctane sulfonate affects intestinal immunity against bacterial infection
title_fullStr	Perfluorooctane sulfonate affects intestinal immunity against bacterial infection
title_full_unstemmed	Perfluorooctane sulfonate affects intestinal immunity against bacterial infection
title_sort	perfluorooctane sulfonate affects intestinal immunity against bacterial infection
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/9a0b6495da0c4a4a8105a707fda58a78
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_version_	1718388660216266752

Perfluorooctane sulfonate affects intestinal immunity against bacterial infection

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