Recent Advances on Cell-Based Co-Culture Strategies for Prevascularization in Tissue Engineering

Currently, the fabrication of a functional vascular network to maintain the viability of engineered tissues is a major bottleneck in the way of developing a more advanced engineered construct. Inspired by vasculogenesis during the embryonic period, the in vitro prevascularization strategies have foc...

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Autores principales:	Sepehr Shafiee, Siavash Shariatzadeh, Ali Zafari, Alireza Majd, Hassan Niknejad
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	co-culture pre-vascularization tissue engineering endothelial cells mesenchymal stem cells fibroblast Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/9a12b0e63c334a5994ac7779032f6302
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spelling	oai:doaj.org-article:9a12b0e63c334a5994ac7779032f63022021-12-01T00:41:23ZRecent Advances on Cell-Based Co-Culture Strategies for Prevascularization in Tissue Engineering2296-418510.3389/fbioe.2021.745314https://doaj.org/article/9a12b0e63c334a5994ac7779032f63022021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fbioe.2021.745314/fullhttps://doaj.org/toc/2296-4185Currently, the fabrication of a functional vascular network to maintain the viability of engineered tissues is a major bottleneck in the way of developing a more advanced engineered construct. Inspired by vasculogenesis during the embryonic period, the in vitro prevascularization strategies have focused on optimizing communications and interactions of cells, biomaterial and culture conditions to develop a capillary-like network to tackle the aforementioned issue. Many of these studies employ a combination of endothelial lineage cells and supporting cells such as mesenchymal stem cells, fibroblasts, and perivascular cells to create a lumenized endothelial network. These supporting cells are necessary for the stabilization of the newly developed endothelial network. Moreover, to optimize endothelial network development without impairing biomechanical properties of scaffolds or differentiation of target tissue cells, several other factors, including target tissue, endothelial cell origins, the choice of supporting cell, culture condition, incorporated pro-angiogenic factors, and choice of biomaterial must be taken into account. The prevascularization method can also influence the endothelial lineage cell/supporting cell co-culture system to vascularize the bioengineered constructs. This review aims to investigate the recent advances on standard cells used in in vitro prevascularization methods, their co-culture systems, and conditions in which they form an organized and functional vascular network.Sepehr ShafieeSiavash ShariatzadehAli ZafariAlireza MajdHassan NiknejadFrontiers Media S.A.articleco-culturepre-vascularizationtissue engineeringendothelial cellsmesenchymal stem cellsfibroblastBiotechnologyTP248.13-248.65ENFrontiers in Bioengineering and Biotechnology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	co-culture pre-vascularization tissue engineering endothelial cells mesenchymal stem cells fibroblast Biotechnology TP248.13-248.65
spellingShingle	co-culture pre-vascularization tissue engineering endothelial cells mesenchymal stem cells fibroblast Biotechnology TP248.13-248.65 Sepehr Shafiee Siavash Shariatzadeh Ali Zafari Alireza Majd Hassan Niknejad Recent Advances on Cell-Based Co-Culture Strategies for Prevascularization in Tissue Engineering
description	Currently, the fabrication of a functional vascular network to maintain the viability of engineered tissues is a major bottleneck in the way of developing a more advanced engineered construct. Inspired by vasculogenesis during the embryonic period, the in vitro prevascularization strategies have focused on optimizing communications and interactions of cells, biomaterial and culture conditions to develop a capillary-like network to tackle the aforementioned issue. Many of these studies employ a combination of endothelial lineage cells and supporting cells such as mesenchymal stem cells, fibroblasts, and perivascular cells to create a lumenized endothelial network. These supporting cells are necessary for the stabilization of the newly developed endothelial network. Moreover, to optimize endothelial network development without impairing biomechanical properties of scaffolds or differentiation of target tissue cells, several other factors, including target tissue, endothelial cell origins, the choice of supporting cell, culture condition, incorporated pro-angiogenic factors, and choice of biomaterial must be taken into account. The prevascularization method can also influence the endothelial lineage cell/supporting cell co-culture system to vascularize the bioengineered constructs. This review aims to investigate the recent advances on standard cells used in in vitro prevascularization methods, their co-culture systems, and conditions in which they form an organized and functional vascular network.
format	article
author	Sepehr Shafiee Siavash Shariatzadeh Ali Zafari Alireza Majd Hassan Niknejad
author_facet	Sepehr Shafiee Siavash Shariatzadeh Ali Zafari Alireza Majd Hassan Niknejad
author_sort	Sepehr Shafiee
title	Recent Advances on Cell-Based Co-Culture Strategies for Prevascularization in Tissue Engineering
title_short	Recent Advances on Cell-Based Co-Culture Strategies for Prevascularization in Tissue Engineering
title_full	Recent Advances on Cell-Based Co-Culture Strategies for Prevascularization in Tissue Engineering
title_fullStr	Recent Advances on Cell-Based Co-Culture Strategies for Prevascularization in Tissue Engineering
title_full_unstemmed	Recent Advances on Cell-Based Co-Culture Strategies for Prevascularization in Tissue Engineering
title_sort	recent advances on cell-based co-culture strategies for prevascularization in tissue engineering
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/9a12b0e63c334a5994ac7779032f6302
work_keys_str_mv	AT sepehrshafiee recentadvancesoncellbasedcoculturestrategiesforprevascularizationintissueengineering AT siavashshariatzadeh recentadvancesoncellbasedcoculturestrategiesforprevascularizationintissueengineering AT alizafari recentadvancesoncellbasedcoculturestrategiesforprevascularizationintissueengineering AT alirezamajd recentadvancesoncellbasedcoculturestrategiesforprevascularizationintissueengineering AT hassanniknejad recentadvancesoncellbasedcoculturestrategiesforprevascularizationintissueengineering
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Recent Advances on Cell-Based Co-Culture Strategies for Prevascularization in Tissue Engineering

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