Dietary Lycopene Supplementation Could Alleviate Aflatoxin B<sub>1</sub> Induced Intestinal Damage through Improving Immune Function and Anti-Oxidant Capacity in Broilers

The present study aims to evaluate the effects of lycopene (LYC) supplementation on the intestinal immune function, barrier function, and antioxidant capacity of broilers fed with aflatoxinB1 (AFB<sub>1</sub>) contaminated diet. A total of 144 one-day-old male Arbor Acres broilers were r...

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Autores principales:	Md Touhiduzzaman Sarker, Xiaoli Wan, Haiming Yang, Zhiyue Wang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	aflatoxinB1 lycopene immune function antioxidant intestine broiler Veterinary medicine SF600-1100 Zoology QL1-991
Acceso en línea:	https://doaj.org/article/9a14600b8fda4bccb71b677178389a4a
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spelling	oai:doaj.org-article:9a14600b8fda4bccb71b677178389a4a2021-11-25T16:17:42ZDietary Lycopene Supplementation Could Alleviate Aflatoxin B<sub>1</sub> Induced Intestinal Damage through Improving Immune Function and Anti-Oxidant Capacity in Broilers10.3390/ani111131652076-2615https://doaj.org/article/9a14600b8fda4bccb71b677178389a4a2021-11-01T00:00:00Zhttps://www.mdpi.com/2076-2615/11/11/3165https://doaj.org/toc/2076-2615The present study aims to evaluate the effects of lycopene (LYC) supplementation on the intestinal immune function, barrier function, and antioxidant capacity of broilers fed with aflatoxinB1 (AFB<sub>1</sub>) contaminated diet. A total of 144 one-day-old male Arbor Acres broilers were randomly divided into three dietary treatment groups; each group consisted of six replicates (eight birds in each cage). Treatments were: (1) a basal diet containing neither AFB<sub>1</sub> nor LYC (Control), (2) basal diet containing 100 µg/kg AFB<sub>1</sub>, and (3) basal diets with 100 µg/kg AFB<sub>1</sub> and 200 mg/kg LYC (AFB<sub>1</sub> and LYC). The results showed that dietary LYC supplementation ameliorated the AFB<sub>1</sub> induced broiler intestinal changes by decreasing the inflammatory cytokines interferon-γ (IFN-γ), interleukin 1beta (IL-1β), and increasing mRNA abundances of cludin-1 (CLDN-1) and zonula occludens-1 (ZO-1) in the jejunum mucosa. On the other hand, AFB<sub>1</sub>-induced increases in serum diamine oxidase (DAO) activities, D-lactate concentration, mucosal malondialdehyde (MDA), and hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) concentrations were reversed by dietary LYC supplementation (<i>p</i> < 0.05). Additionally, LYC supplementation ameliorated the redox balance through increasing the antioxidant enzyme activities and their related mRNA expression abundances compared to AFB<sub>1</sub> exposed broilers. In conclusion, dietary supplementation with LYC could alleviate AFB<sub>1</sub> induced broiler intestinal immune function and barrier function damage and improve antioxidants status.Md Touhiduzzaman SarkerXiaoli WanHaiming YangZhiyue WangMDPI AGarticleaflatoxinB1lycopeneimmune functionantioxidantintestinebroilerVeterinary medicineSF600-1100ZoologyQL1-991ENAnimals, Vol 11, Iss 3165, p 3165 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	aflatoxinB1 lycopene immune function antioxidant intestine broiler Veterinary medicine SF600-1100 Zoology QL1-991
spellingShingle	aflatoxinB1 lycopene immune function antioxidant intestine broiler Veterinary medicine SF600-1100 Zoology QL1-991 Md Touhiduzzaman Sarker Xiaoli Wan Haiming Yang Zhiyue Wang Dietary Lycopene Supplementation Could Alleviate Aflatoxin B<sub>1</sub> Induced Intestinal Damage through Improving Immune Function and Anti-Oxidant Capacity in Broilers
description	The present study aims to evaluate the effects of lycopene (LYC) supplementation on the intestinal immune function, barrier function, and antioxidant capacity of broilers fed with aflatoxinB1 (AFB<sub>1</sub>) contaminated diet. A total of 144 one-day-old male Arbor Acres broilers were randomly divided into three dietary treatment groups; each group consisted of six replicates (eight birds in each cage). Treatments were: (1) a basal diet containing neither AFB<sub>1</sub> nor LYC (Control), (2) basal diet containing 100 µg/kg AFB<sub>1</sub>, and (3) basal diets with 100 µg/kg AFB<sub>1</sub> and 200 mg/kg LYC (AFB<sub>1</sub> and LYC). The results showed that dietary LYC supplementation ameliorated the AFB<sub>1</sub> induced broiler intestinal changes by decreasing the inflammatory cytokines interferon-γ (IFN-γ), interleukin 1beta (IL-1β), and increasing mRNA abundances of cludin-1 (CLDN-1) and zonula occludens-1 (ZO-1) in the jejunum mucosa. On the other hand, AFB<sub>1</sub>-induced increases in serum diamine oxidase (DAO) activities, D-lactate concentration, mucosal malondialdehyde (MDA), and hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) concentrations were reversed by dietary LYC supplementation (<i>p</i> < 0.05). Additionally, LYC supplementation ameliorated the redox balance through increasing the antioxidant enzyme activities and their related mRNA expression abundances compared to AFB<sub>1</sub> exposed broilers. In conclusion, dietary supplementation with LYC could alleviate AFB<sub>1</sub> induced broiler intestinal immune function and barrier function damage and improve antioxidants status.
format	article
author	Md Touhiduzzaman Sarker Xiaoli Wan Haiming Yang Zhiyue Wang
author_facet	Md Touhiduzzaman Sarker Xiaoli Wan Haiming Yang Zhiyue Wang
author_sort	Md Touhiduzzaman Sarker
title	Dietary Lycopene Supplementation Could Alleviate Aflatoxin B<sub>1</sub> Induced Intestinal Damage through Improving Immune Function and Anti-Oxidant Capacity in Broilers
title_short	Dietary Lycopene Supplementation Could Alleviate Aflatoxin B<sub>1</sub> Induced Intestinal Damage through Improving Immune Function and Anti-Oxidant Capacity in Broilers
title_full	Dietary Lycopene Supplementation Could Alleviate Aflatoxin B<sub>1</sub> Induced Intestinal Damage through Improving Immune Function and Anti-Oxidant Capacity in Broilers
title_fullStr	Dietary Lycopene Supplementation Could Alleviate Aflatoxin B<sub>1</sub> Induced Intestinal Damage through Improving Immune Function and Anti-Oxidant Capacity in Broilers
title_full_unstemmed	Dietary Lycopene Supplementation Could Alleviate Aflatoxin B<sub>1</sub> Induced Intestinal Damage through Improving Immune Function and Anti-Oxidant Capacity in Broilers
title_sort	dietary lycopene supplementation could alleviate aflatoxin b<sub>1</sub> induced intestinal damage through improving immune function and anti-oxidant capacity in broilers
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/9a14600b8fda4bccb71b677178389a4a
work_keys_str_mv	AT mdtouhiduzzamansarker dietarylycopenesupplementationcouldalleviateaflatoxinbsub1subinducedintestinaldamagethroughimprovingimmunefunctionandantioxidantcapacityinbroilers AT xiaoliwan dietarylycopenesupplementationcouldalleviateaflatoxinbsub1subinducedintestinaldamagethroughimprovingimmunefunctionandantioxidantcapacityinbroilers AT haimingyang dietarylycopenesupplementationcouldalleviateaflatoxinbsub1subinducedintestinaldamagethroughimprovingimmunefunctionandantioxidantcapacityinbroilers AT zhiyuewang dietarylycopenesupplementationcouldalleviateaflatoxinbsub1subinducedintestinaldamagethroughimprovingimmunefunctionandantioxidantcapacityinbroilers
_version_	1718413271596269568

Dietary Lycopene Supplementation Could Alleviate Aflatoxin B<sub>1</sub> Induced Intestinal Damage through Improving Immune Function and Anti-Oxidant Capacity in Broilers

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