Dynamic Diversity of Glial Response Among Species in Spinal Cord Injury

The glial scar that forms after traumatic spinal cord injury (SCI) is mostly composed of microglia, NG2 glia, and astrocytes and plays dual roles in pathophysiological processes induced by the injury. On one hand, the glial scar acts as a chemical and physical obstacle to spontaneous axonal regenera...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jean-Christophe Perez, Yannick N. Gerber, Florence E. Perrin
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	spinal cord injury (SCI) glial cells immune cells glial scar glial bridge rodents Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/9a1ecb0feee54b149827c9bf079a23c5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9a1ecb0feee54b149827c9bf079a23c5
record_format	dspace
spelling	oai:doaj.org-article:9a1ecb0feee54b149827c9bf079a23c52021-12-01T08:05:21ZDynamic Diversity of Glial Response Among Species in Spinal Cord Injury1663-436510.3389/fnagi.2021.769548https://doaj.org/article/9a1ecb0feee54b149827c9bf079a23c52021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnagi.2021.769548/fullhttps://doaj.org/toc/1663-4365The glial scar that forms after traumatic spinal cord injury (SCI) is mostly composed of microglia, NG2 glia, and astrocytes and plays dual roles in pathophysiological processes induced by the injury. On one hand, the glial scar acts as a chemical and physical obstacle to spontaneous axonal regeneration, thus preventing functional recovery, and, on the other hand, it partly limits lesion extension. The complex activation pattern of glial cells is associated with cellular and molecular crosstalk and interactions with immune cells. Interestingly, response to SCI is diverse among species: from amphibians and fishes that display rather limited (if any) glial scarring to mammals that exhibit a well-identifiable scar. Additionally, kinetics of glial activation varies among species. In rodents, microglia become activated before astrocytes, and both glial cell populations undergo activation processes reflected amongst others by proliferation and migration toward the injury site. In primates, glial cell activation is delayed as compared to rodents. Here, we compare the spatial and temporal diversity of the glial response, following SCI amongst species. A better understanding of mechanisms underlying glial activation and scar formation is a prerequisite to develop timely glial cell-specific therapeutic strategies that aim to increase functional recovery.Jean-Christophe PerezYannick N. GerberFlorence E. PerrinFlorence E. PerrinFrontiers Media S.A.articlespinal cord injury (SCI)glial cellsimmune cellsglial scarglial bridgerodentsNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Aging Neuroscience, Vol 13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	spinal cord injury (SCI) glial cells immune cells glial scar glial bridge rodents Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	spinal cord injury (SCI) glial cells immune cells glial scar glial bridge rodents Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Jean-Christophe Perez Yannick N. Gerber Florence E. Perrin Florence E. Perrin Dynamic Diversity of Glial Response Among Species in Spinal Cord Injury
description	The glial scar that forms after traumatic spinal cord injury (SCI) is mostly composed of microglia, NG2 glia, and astrocytes and plays dual roles in pathophysiological processes induced by the injury. On one hand, the glial scar acts as a chemical and physical obstacle to spontaneous axonal regeneration, thus preventing functional recovery, and, on the other hand, it partly limits lesion extension. The complex activation pattern of glial cells is associated with cellular and molecular crosstalk and interactions with immune cells. Interestingly, response to SCI is diverse among species: from amphibians and fishes that display rather limited (if any) glial scarring to mammals that exhibit a well-identifiable scar. Additionally, kinetics of glial activation varies among species. In rodents, microglia become activated before astrocytes, and both glial cell populations undergo activation processes reflected amongst others by proliferation and migration toward the injury site. In primates, glial cell activation is delayed as compared to rodents. Here, we compare the spatial and temporal diversity of the glial response, following SCI amongst species. A better understanding of mechanisms underlying glial activation and scar formation is a prerequisite to develop timely glial cell-specific therapeutic strategies that aim to increase functional recovery.
format	article
author	Jean-Christophe Perez Yannick N. Gerber Florence E. Perrin Florence E. Perrin
author_facet	Jean-Christophe Perez Yannick N. Gerber Florence E. Perrin Florence E. Perrin
author_sort	Jean-Christophe Perez
title	Dynamic Diversity of Glial Response Among Species in Spinal Cord Injury
title_short	Dynamic Diversity of Glial Response Among Species in Spinal Cord Injury
title_full	Dynamic Diversity of Glial Response Among Species in Spinal Cord Injury
title_fullStr	Dynamic Diversity of Glial Response Among Species in Spinal Cord Injury
title_full_unstemmed	Dynamic Diversity of Glial Response Among Species in Spinal Cord Injury
title_sort	dynamic diversity of glial response among species in spinal cord injury
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/9a1ecb0feee54b149827c9bf079a23c5
work_keys_str_mv	AT jeanchristopheperez dynamicdiversityofglialresponseamongspeciesinspinalcordinjury AT yannickngerber dynamicdiversityofglialresponseamongspeciesinspinalcordinjury AT florenceeperrin dynamicdiversityofglialresponseamongspeciesinspinalcordinjury AT florenceeperrin dynamicdiversityofglialresponseamongspeciesinspinalcordinjury
_version_	1718405428668268544

Dynamic Diversity of Glial Response Among Species in Spinal Cord Injury

Ejemplares similares