Copper-catalyzed dehydrogenative γ-C(sp3)-H amination of saturated ketones for synthesis of polysubstituted anilines
Functionalising ketones at the γ-position is not a trivial synthetic task. Here, the authors developed a copper-catalyzed dehydrogenative γ-amination of saturated ketones, which can then participate in a 3-component coupling reaction to construct polysubstituted anilines.
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| Autores principales: | , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2019
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/9a216314fdc348f1815594844afa475c |
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| Sumario: | Functionalising ketones at the γ-position is not a trivial synthetic task. Here, the authors developed a copper-catalyzed dehydrogenative γ-amination of saturated ketones, which can then participate in a 3-component coupling reaction to construct polysubstituted anilines. |
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