Copper-catalyzed dehydrogenative γ-C(sp3)-H amination of saturated ketones for synthesis of polysubstituted anilines

Functionalising ketones at the γ-position is not a trivial synthetic task. Here, the authors developed a copper-catalyzed dehydrogenative γ-amination of saturated ketones, which can then participate in a 3-component coupling reaction to construct polysubstituted anilines.

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Autores principales:	Rong Hu, Fa-Jie Chen, Xiaofeng Zhang, Min Zhang, Weiping Su
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9a216314fdc348f1815594844afa475c
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spelling	oai:doaj.org-article:9a216314fdc348f1815594844afa475c2021-12-02T14:38:47ZCopper-catalyzed dehydrogenative γ-C(sp3)-H amination of saturated ketones for synthesis of polysubstituted anilines10.1038/s41467-019-11624-92041-1723https://doaj.org/article/9a216314fdc348f1815594844afa475c2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11624-9https://doaj.org/toc/2041-1723Functionalising ketones at the γ-position is not a trivial synthetic task. Here, the authors developed a copper-catalyzed dehydrogenative γ-amination of saturated ketones, which can then participate in a 3-component coupling reaction to construct polysubstituted anilines.Rong HuFa-Jie ChenXiaofeng ZhangMin ZhangWeiping SuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rong Hu Fa-Jie Chen Xiaofeng Zhang Min Zhang Weiping Su Copper-catalyzed dehydrogenative γ-C(sp3)-H amination of saturated ketones for synthesis of polysubstituted anilines
description	Functionalising ketones at the γ-position is not a trivial synthetic task. Here, the authors developed a copper-catalyzed dehydrogenative γ-amination of saturated ketones, which can then participate in a 3-component coupling reaction to construct polysubstituted anilines.
format	article
author	Rong Hu Fa-Jie Chen Xiaofeng Zhang Min Zhang Weiping Su
author_facet	Rong Hu Fa-Jie Chen Xiaofeng Zhang Min Zhang Weiping Su
author_sort	Rong Hu
title	Copper-catalyzed dehydrogenative γ-C(sp3)-H amination of saturated ketones for synthesis of polysubstituted anilines
title_short	Copper-catalyzed dehydrogenative γ-C(sp3)-H amination of saturated ketones for synthesis of polysubstituted anilines
title_full	Copper-catalyzed dehydrogenative γ-C(sp3)-H amination of saturated ketones for synthesis of polysubstituted anilines
title_fullStr	Copper-catalyzed dehydrogenative γ-C(sp3)-H amination of saturated ketones for synthesis of polysubstituted anilines
title_full_unstemmed	Copper-catalyzed dehydrogenative γ-C(sp3)-H amination of saturated ketones for synthesis of polysubstituted anilines
title_sort	copper-catalyzed dehydrogenative γ-c(sp3)-h amination of saturated ketones for synthesis of polysubstituted anilines
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/9a216314fdc348f1815594844afa475c
work_keys_str_mv	AT ronghu coppercatalyzeddehydrogenativegcsp3haminationofsaturatedketonesforsynthesisofpolysubstitutedanilines AT fajiechen coppercatalyzeddehydrogenativegcsp3haminationofsaturatedketonesforsynthesisofpolysubstitutedanilines AT xiaofengzhang coppercatalyzeddehydrogenativegcsp3haminationofsaturatedketonesforsynthesisofpolysubstitutedanilines AT minzhang coppercatalyzeddehydrogenativegcsp3haminationofsaturatedketonesforsynthesisofpolysubstitutedanilines AT weipingsu coppercatalyzeddehydrogenativegcsp3haminationofsaturatedketonesforsynthesisofpolysubstitutedanilines
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Copper-catalyzed dehydrogenative γ-C(sp3)-H amination of saturated ketones for synthesis of polysubstituted anilines

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